{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T07:01:51Z","timestamp":1777014111744,"version":"3.51.4"},"reference-count":54,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: To integrate the available published data on patients with oral lichen planus (OLP) rehabilitated with dental implants, as well as to review the recommendations for OLP patients receiving implants. Materials and Methods: An electronic search was undertaken in February 2019 using five databases. Publications reporting cases of patients with OLP and rehabilitated with implant-supported oral prosthesis were included. Results: Twenty-two publications were included (230 patients, 615 implants). The overall implant failure rate was 13.9% (85\/610). In patients with oral squamous cell carcinoma (OSCC) the failure rate was 90.6% (29\/32), but none of these implants lost osseointegration; instead, the implants were removed together with the tumor. One study presented a very high implant failure rate, 76.4% (42\/55), in patients with \u201cactive lichen planus\u201d, with all implants failing between 7\u201316 weeks after implant placement, and its conflicting and incongruent results are discussed in detail. There was a statistically significant difference between the failure rates in implants installed in different jaws (maxilla\/mandible) and when implants of different surfaces were used (turned\/moderately rough), but not between patients with reticular or erosive OLP types, or between male and female patients. If OSCC patients and the cases of the latter study are not considered, then the failure rate becomes very low (2.7%, 14\/523). The time between implant placement and failure was 25.4 \u00b1 32.6 months (range 1\u2013112). The mean \u00b1 SD follow-up was 58.9 \u00b1 26.7 months (1\u2013180). Conclusions: When the results of the one study with a very high failure rate and of the cases that developed OSCC are not considered, the dental implant failure rate in OLP patients was 2.7% after a follow-up of approximately five years. Recommendations are given when treating OLP patients with dental implants.<\/jats:p>","DOI":"10.3390\/medicina56020053","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T11:41:57Z","timestamp":1580125317000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dental Implants in Patients with Oral Lichen Planus: A Systematic Review"],"prefix":"10.3390","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3460-3374","authenticated-orcid":false,"given":"Bruno","family":"Chrcanovic","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Faculty of Odontology, Malm\u00f6 University, 214 21 Malm\u00f6, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1624-6702","authenticated-orcid":false,"given":"Ricardo","family":"Trindade","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Odontology, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-8009","authenticated-orcid":false,"given":"Ricardo","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.oooo.2016.05.004","article-title":"Diagnosis of oral lichen planus: A position paper of the American Academy of Oral and Maxillofacial Pathology","volume":"122","author":"Cheng","year":"2016","journal-title":"Oral Surgery Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1600-0714.2010.00946.x","article-title":"Pathogenesis of oral lichen planus\u2014A review","volume":"39","author":"Roopashree","year":"2010","journal-title":"J. Oral Pathol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-0528.1987.tb00480.x","article-title":"Oral lichen planus\u2014A demographic study","volume":"15","author":"Rundquist","year":"1987","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_4","first-page":"S237","article-title":"Peri-implant mucositis","volume":"45","author":"Salvi","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., and PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/jopr.12379","article-title":"Clinical Management Protocol for Dental Implants Inserted in Patients with Active Lichen Planus","volume":"26","author":"Aboushelib","year":"2017","journal-title":"J. Prosthodont."},{"key":"ref_7","first-page":"458","article-title":"Peri-implantitis or squamous cell carcinoma?","volume":"108","author":"Trost","year":"2007","journal-title":"Rev. Stomatol. Chir. Maxillofac."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bjoms.2018.02.003","article-title":"Short dental implants in patients with oral lichen planus: A long-term follow-up","volume":"56","author":"Anitua","year":"2018","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.11607\/jomi.5888","article-title":"Association of Systemic Conditions with Dental Implant Failures in 6,384 Patients During a 31-Year Follow-up Period","volume":"32","author":"Carr","year":"2017","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_10","first-page":"59","article-title":"Carcinoma epidermoide oral alrededor de implantes osteointegrados: A prop\u00f3sito de un caso y revisi\u00f3n bibliogr\u00e1fica","volume":"70","year":"2018","journal-title":"Rev. Chilena Cirug."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1708-8208.2011.00347.x","article-title":"Oral lichen planus and dental implants\u2014A retrospective study","volume":"15","author":"Czerninski","year":"2013","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_12","first-page":"707","article-title":"Oral squamous cell carcinoma around dental implants","volume":"37","author":"Czerninski","year":"2006","journal-title":"Quintessence Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1708-8208.2000.tb00103.x","article-title":"Histopathologic observations on late oral implant failures","volume":"2","author":"Esposito","year":"2000","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1067\/mpr.2003.14","article-title":"Implant retained overdentures for two patients with severe lichen planus: A clinical report","volume":"89","author":"Esposito","year":"2003","journal-title":"J. Prosthet. Dent."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.joms.2018.07.031","article-title":"Implant-Retained Overdenture for a Patient With Severe Lichen Planus: A Case Report With 3 Years\u2019 Follow-Up and a Systematic Review","volume":"77","author":"Fu","year":"2019","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.14219\/jada.archive.2008.0308","article-title":"Oral squamous cell carcinoma associated with symphyseal dental implants: An unusual case report","volume":"139","author":"Gallego","year":"2008","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1600-0501.2011.02192.x","article-title":"Implant treatment in patients with oral lichen planus: A prospective-controlled study","volume":"23","author":"Arriba","year":"2012","journal-title":"Clin. Oral Implants Res."},{"key":"ref_18","first-page":"131","article-title":"A Case Report of Oral Lichen Planus after Implant Treatment","volume":"29","author":"Kato","year":"2016","journal-title":"J. Jap. Soc. Oral Implant"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/jopr.12993","article-title":"Clinical Management Protocol for Dental Implants Inserted in Patients with Active Lichen Planus. Part II 4-Year Follow-Up","volume":"28","author":"Khamis","year":"2019","journal-title":"J. Prosthodont."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1708-8208.2012.00455.x","article-title":"Dental implants in patients with oral lichen planus: A cross-sectional study","volume":"16","year":"2014","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.joms.2012.06.184","article-title":"Peri-implant Primary Squamous Cell Carcinoma: A Case Report With 5 Years\u2019 Follow-Up","volume":"71","author":"Marini","year":"2013","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00784-013-0968-5","article-title":"Oral squamous cell carcinoma in the vicinity of dental implants","volume":"18","author":"Moergel","year":"2014","journal-title":"Clin. Oral Investig."},{"key":"ref_23","first-page":"383","article-title":"Implant-prosthodontic treatment for special care patients: A case series study","volume":"18","author":"Oczakir","year":"2005","journal-title":"Int. J. Prosthodont."},{"key":"ref_24","first-page":"113","article-title":"Dental implants in patients with oral lichen planus. Literature review in related to three clinical cases","volume":"17","year":"2012","journal-title":"Rev. Cons. Odontol. Estomatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.joms.2016.02.008","article-title":"Primary Oral Malignancy Imitating Peri-Implantitis","volume":"74","author":"Raiser","year":"2016","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ijom.2005.08.011","article-title":"Oral lichen planus and dental implants","volume":"35","author":"Reichart","year":"2006","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.5005\/jp-journals-10024-1594","article-title":"A Clinical Report of an Oral Lichen Planus associated to Epidermoid Carcinoma in Contact with Metallic Restorations","volume":"15","author":"Paleari","year":"2014","journal-title":"J. Contemp. Dent. Pr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.jcms.2018.05.038","article-title":"Dental implants in patients with ectodermal dysplasia: A systematic review","volume":"46","author":"Chrcanovic","year":"2018","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jormas.2019.01.010","article-title":"Peripheral giant cell granuloma associated with dental implants: A systematic review","volume":"120","author":"Chrcanovic","year":"2019","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.jcms.2016.07.030","article-title":"Survival and complications of implants to support craniofacial prosthesis: A systematic review","volume":"44","author":"Chrcanovic","year":"2016","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.ijom.2019.02.005","article-title":"Dental implants in patients with Sj\u00f6gren\u2019s syndrome: A case series and a systematic review","volume":"48","author":"Chrcanovic","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/hed.23875","article-title":"Dental implants in irradiated versus nonirradiated patients: A meta-analysis","volume":"38","author":"Chrcanovic","year":"2016","journal-title":"Head Neck"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.11607\/ijp.5142","article-title":"Bone Quality and Quantity and Dental Implant Failure: A Systematic Review and Meta-analysis","volume":"30","author":"Chrcanovic","year":"2017","journal-title":"Int. J. Prosthodont."},{"key":"ref_34","first-page":"270","article-title":"The importance of implant surface characteristics in the replacement of failed implants","volume":"21","author":"Alsaadi","year":"2006","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1902\/jop.2007.060516","article-title":"Success and Survival of Single Dental Implants Placed in Sites of Previously Failed Implants","volume":"78","author":"Grossmann","year":"2007","journal-title":"J. Periodontol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-0501.2007.01466.x","article-title":"Dental implants placed in previously failed sites: Survival rate and factors affecting the outcome","volume":"19","author":"Machtei","year":"2008","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.tripleo.2010.01.031","article-title":"Prognosis of the implants replaced after removal of failed dental implants","volume":"110","author":"Kim","year":"2010","journal-title":"Oral Surgery, Oral Med. Oral Pathol. Oral Radiol. Endodontology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/clr.12992","article-title":"Survival of dental implants placed in sites of previously failed implants","volume":"28","author":"Chrcanovic","year":"2017","journal-title":"Clin. Oral Implants Res."},{"key":"ref_39","first-page":"e737","article-title":"Response to Letter to the Editor","volume":"28","author":"Aboushelib","year":"2019","journal-title":"J. Prosthodont."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bjoms.2007.07.199","article-title":"Oral mucosal disease: Lichen planus","volume":"46","author":"Scully","year":"2008","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Trindade, R., Albrektsson, T., Galli, S., Prgomet, Z., Tengvall, P., and Wennerberg, A. (2018). Bone Immune Response to Materials, Part I: Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia. J. Clin. Med., 7.","DOI":"10.3390\/jcm7120526"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/jbm.a.10279","article-title":"Modulation of bone ingrowth and tissue differentiation by local infusion of interleukin-10 in the presence of ultra-high molecular weight polyethylene (UHMWPE) wear particles","volume":"65","author":"Goodman","year":"2003","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2353\/ajpath.2009.080962","article-title":"Localized Immunosuppressive Environment in the Foreign Body Response to Implanted Biomaterials","volume":"175","author":"Higgins","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/154411130201300405","article-title":"The pathogenesis of oral lichen planus","volume":"13","author":"Sugerman","year":"2002","journal-title":"Crit. Rev. Oral Boil. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0738-081X(00)00142-5","article-title":"Oral lichen planus","volume":"18","author":"Sugerman","year":"2000","journal-title":"Clin. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Shi, Q., Zhang, T., Huo, N., Huang, Y., Xu, J., and Liu, H. (2017). Association between polymorphisms in interleukins and oral lichen planus: A meta-analysis. Medicine, 96.","DOI":"10.1097\/MD.0000000000006314"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Chen, B., Yan, F., Guo, J., Zhu, X., Ma, S., and Yang, W. (2014). Interleukin-10 Inhibits Bone Resorption: A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/284836"},{"key":"ref_48","unstructured":"Freedberg, I., Eisen, A., Wolff, K., Austen, K.F., Goldsmith, L.A., and Fitzpatrick, T.B. (1999). Fitzpatrick\u2019s Dermatology in General Medicine, McGraw-Hill. [5th ed.]."},{"key":"ref_49","first-page":"85","article-title":"The measurement of serum TNF-alpha levels in patients with lichen planus","volume":"26","year":"2017","journal-title":"Acta Dermatovenerol. Alp. Pannonica Adriat."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1708-8208.2010.00309.x","article-title":"Gene expression of inflammation and bone healing in peri-implant crevicular fluid after placement and loading of dental implants. A kinetic clinical pilot study using quantitative real-time PCR","volume":"14","author":"Slotte","year":"2012","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/cid.12571","article-title":"A retrospective study on clinical and radiological outcomes of oral implants in patients followed up for a minimum of 20 years","volume":"20","author":"Chrcanovic","year":"2018","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_52","first-page":"s37","article-title":"Foreign body reactions, marginal bone loss and allergies in relation to titanium implants","volume":"11","author":"Albrektsson","year":"2018","journal-title":"Eur. J. Oral Implantol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/prd.12176","article-title":"Initial and long-term crestal bone responses to modern dental implants","volume":"73","author":"Albrektsson","year":"2017","journal-title":"Periodontol. 2000"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/jop.12827","article-title":"Some methodological issues on the review of pathologic lesions and conditions","volume":"48","author":"Chrcanovic","year":"2019","journal-title":"J. Oral Pathol. Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/2\/53\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:30:33Z","timestamp":1760362233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/2\/53"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,27]]},"references-count":54,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["medicina56020053"],"URL":"https:\/\/doi.org\/10.3390\/medicina56020053","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,27]]}}}