{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:44:14Z","timestamp":1771065854440,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Backround and Objective: We sought to assess in adult congenital heart disease (ACHD) patients the prognostic value of plasma galectin-3 (Gal-3) levels and systemic ventricular global longitudinal strain (SV GLS) as well as their association with NTproBNP and arrhythmogenesis. Materials and Methods: We studied 58 patients (26 men, mean age 37 \u00b1 16.8 years) with various congenital heart diseases. Patients underwent echocardiogram, 24 h ambulatory ECG monitoring, while NTproBNP and Gal-3 were measured. They were followed up (median of 790.5 days -IQR 350.3 days) and major cardiovascular events (MACE) were recorded. Results. Mean Gal-3 levels were 17.07 \u00b1 6.38 ng\/m. Plasma Gal-3 was correlated with LogNTproBNP (r = 0.456, p = 0.001).Gal-3 levels associated with supraventricular tachycardia (SVT) (p &lt; 0.001) and ventricular tachycardia (VT) (p &lt; 0.001), but was not associated with MACE (HR 1.018, 95% CI 0.944\u20131.098, p = 0.641).Mean SVGLS in patients with systemic left ventricle was \u221215.91% \u00b1 4.09%, which was significantly lower compared to patients with systemic right ventricle and patients with single ventricle (\u221211.42% \u00b1 3.37% and \u221211.9% \u00b1 5.06%, respectively, p = 0.021).SV GLS correlated with plasma Gal-3 (r = 0.313, p = 0.027) and logNTproBNP (r = 0.479, p &lt; 0.001). SVGLS correlated with VT arrhythmias (p = 0.004). NTproBNP predicted MACE (AUC 0.750, p = 0.03). SVGLS also predicted MACE (AUC 0.745, p = 0.03. In multivariate analysis, SVGLS and logNTproBNP maintained their predictive value (p = 0.004 and p = 0.009, respectively) Conclusion: In ACHD patients, SV GLS was found to predict MACE independently from NTproBNP and correlated with VT. Gal-3 correlated with NTproBNP and SVGLS as well as SVT and VT, but has not been shown to bear significant prognostic potential.<\/jats:p>","DOI":"10.3390\/medicina56060305","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T06:11:02Z","timestamp":1592892662000},"page":"305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Global Longitudinal Strain of the Systemic Ventricle Is Correlated with Plasma Galectin-3 and Predicts Major Cardiovascular Events in Adult Patients with Congenital Heart Disease"],"prefix":"10.3390","volume":"56","author":[{"given":"Alexandra A.","family":"Frogoudaki","sequence":"first","affiliation":[{"name":"Second Cardiology Department, ATTIKON University Hospital, National and Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Pantelakis","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, ATTIKON University Hospital, National and Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3734-5443","authenticated-orcid":false,"given":"Vasiliki","family":"Bistola","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, ATTIKON University Hospital, National and Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-2599","authenticated-orcid":false,"given":"Christos","family":"Kroupis","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, ATTIKON University Hospital, National and Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionysia","family":"Birba","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, ATTIKON University Hospital, National and Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-7886","authenticated-orcid":false,"given":"Ignatios","family":"Ikonomidis","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, ATTIKON University Hospital, National and Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Alexopoulos","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, ATTIKON University Hospital, National and Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, ATTIKON University Hospital, National and Kapodistrian University of Athens, 12461 Athens, Greece"},{"name":"Medical School, University of Cyprus, 2029 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Parissis","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, ATTIKON University Hospital, National and Kapodistrian University of Athens, 12461 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijcard.2010.09.015","article-title":"Circumstances of death in adult congenital heart disease","volume":"154","author":"Zomer","year":"2012","journal-title":"Int. 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