{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:35:03Z","timestamp":1768566903068,"version":"3.49.0"},"reference-count":36,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["INFR-2014-01-225520, INFR-2015-01-254106, PDCPN-2015-01-63, SEP-CONACYT-CB-2015-258316, and SS\/IMSS\/ISSSTE-CONACYT-2016-01-273144"],"award-info":[{"award-number":["INFR-2014-01-225520, INFR-2015-01-254106, PDCPN-2015-01-63, SEP-CONACYT-CB-2015-258316, and SS\/IMSS\/ISSSTE-CONACYT-2016-01-273144"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Pytiriasis alba (PA) is a common skin disorder which affects 80% of children between six and 16 years. The etiology of PA is unclear, but hypo-pigmented patches in photo-exposed zones characterize the disease. Because the high ultraviolet exposition of the skin promotes an acute inflammatory response and an increase of oxidative stress (OS), this study aimed to evaluate the expression levels of inflammatory and OS-related genes in skin biopsies, and their association with PA. Materials and Methods: A cross-sectional study was carried out. Skin biopsies of the lesion sites and healthy skin (controls) from 16 children with PA were evaluated. The tissue expression of IL-4, IL-6, IL-17A, TNF\u03b1, INF\u03b3, IL-1\u03b2, SOD1, and HMOX1 was analyzed by qRT-PCR, using SYBR Green and glyceraldehyde-3-phosphate dehydrogenase gene as the endogenous control. Results: There were differences in the \u0394Cq values of HMOX1, SOD1, IL-6, and IFN\u03b3 between tissue with lesions and healthy skin (p &lt; 0.05). Compared with healthy skin, IL-6, IFN\u03b3, HMOX1, and SOD1 were predominantly under-expressed in the lesion sites. However, 25% of skin biopsies with lesions showed over-expression of these four genes. Positive correlations between the expression of IL-6 and HMOX1, SOD1, and IFN\u03b3 (p &lt; 0.05) were also observed. Conclusions: Our results suggest the presence of molecular stages of PA, defined according to the over-expression (first stage) or under-expression (second stage) of the HMOX1, SOD1, IL-6, and IFN\u03b3 genes in abnormal skin tissue. These findings may have implications for the selection of treatment for PA-related lesions.<\/jats:p>","DOI":"10.3390\/medicina56070359","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T10:22:02Z","timestamp":1594981322000},"page":"359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expression Levels of Inflammatory and Oxidative Stress-Related Genes in Skin Biopsies and Their Association with Pityriasis Alba"],"prefix":"10.3390","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-9068","authenticated-orcid":false,"given":"Margarita L.","family":"Martinez-Fierro","sequence":"first","affiliation":[{"name":"Molecular Medicine Laboratory, Doctorado en Ciencias con Orientaci\u00f3n en Medicina Molecular, Unidad Acad\u00e9mica de Medicina Humana y C.S., Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Griselda A.","family":"Cabral-Pacheco","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Doctorado en Ciencias con Orientaci\u00f3n en Medicina Molecular, Unidad Acad\u00e9mica de Medicina Humana y C.S., Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-1696","authenticated-orcid":false,"given":"Idalia","family":"Garza-Veloz","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Doctorado en Ciencias con Orientaci\u00f3n en Medicina Molecular, Unidad Acad\u00e9mica de Medicina Humana y C.S., Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s E.","family":"Campuzano-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital General Zacatecas \u201cLuz Gonz\u00e1lez Cos\u00edo\u201d, Servicios de Salud de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma P.","family":"D\u00edaz-Alonso","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Doctorado en Ciencias con Orientaci\u00f3n en Medicina Molecular, Unidad Acad\u00e9mica de Medicina Humana y C.S., Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"},{"name":"Hospital General Zacatecas \u201cLuz Gonz\u00e1lez Cos\u00edo\u201d, Servicios de Salud de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4540-1011","authenticated-orcid":false,"given":"Virginia","family":"Flores-Morales","sequence":"additional","affiliation":[{"name":"Laboratorio de S\u00edntesis Asim\u00e9trica y Bioenerg\u00e9tica (LSAyB), Doctorado en Ciencias con Orientaci\u00f3n en Medicina Molecular, Unidad Acad\u00e9mica de Medicina Humana y C.S., Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-4168","authenticated-orcid":false,"given":"Iram P.","family":"Rodriguez-Sanchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Molecular y Estructural, Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 66455, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9848-862X","authenticated-orcid":false,"given":"Ivan","family":"Delgado-Enciso","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Colima, and Cancerology State Institute, Colima State Health Services, Colima 28040, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Rios-Jasso","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Doctorado en Ciencias con Orientaci\u00f3n en Medicina Molecular, Unidad Acad\u00e9mica de Medicina Humana y C.S., Universidad Aut\u00f3noma de Zacatecas, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0025-7125(05)70420-X","article-title":"Pediatric dermatology","volume":"82","author":"Hanson","year":"1998","journal-title":"Med. 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