{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:03:04Z","timestamp":1760238184620,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The tuberous sclerosis complex (TSC) is highly variable as far as its clinical presentation is concerned. For the implementation of appropriate medical surveillance and treatment, an accurate diagnosis is compulsory. TSC may affect the heart, skin, kidneys, central nervous system (epileptic seizures and nodular intracranial tumors\u2014tubers), bones, eyes, lungs, blood vessels and the gastrointestinal tract. The aim of this paper is to report renal manifestations as first clinical signs suggestive of TSC diagnosis. A 20-year-old patient was initially investigated for hematuria, dysuria and colicky pain in the left lumbar region. The ultrasound examination of the kidney showed bilateral hyperechogenic kidney structures and pyelocalyceal dilatation, both suggestive of bilateral obstructive lithiasis, complicated by uretero-hydronephrosis. The computer tomography (CT) scan of the kidney showed irregular kidney margins layout, undifferentiated images between cortical and medullar structures, with non-homogenous round components, suggestive of kidney angiomyolipomas, bilateral renal cortical retention cysts, images of a calculous component in the right middle calyceal branches and a smaller one on the left side. The clinical manifestations and imaging findings (skull and abdominal and pelvis CT scans) sustained the diagnosis.<\/jats:p>","DOI":"10.3390\/medicina56080369","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T10:14:06Z","timestamp":1595499246000},"page":"369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Management of a Patient with Tuberous Sclerosis with Urological Clinical Manifestations"],"prefix":"10.3390","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-5689","authenticated-orcid":false,"given":"Vlad","family":"Padureanu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octavian","family":"Dragoescu","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Emanuel","family":"Stoenescu","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-736X","authenticated-orcid":false,"given":"Rodica","family":"Padureanu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ionica","family":"Pirici","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu Cristian","family":"Cimpeanu","sequence":"additional","affiliation":[{"name":"Student, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dop","family":"Dalia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru Radu","family":"Mihailovici","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Tomescu","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pediatrneurol.2013.08.001","article-title":"International Tuberous Sclerosis Complex Consensus Group. 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Tuberous Sclerosis Complex: Genes, Clinical Features, and Therapeutics, Wiley-Blackwell.","DOI":"10.1002\/9783527630073"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0025-6196(12)61196-3","article-title":"Causes of Death in Patients with Tuberous Sclerosis","volume":"66","author":"Shepherd","year":"1991","journal-title":"Mayo Clin. Proc."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kwiatkowsi, D., Whittemore, V., and Thiele, E. (2010). Renal manifestations of tuberous sclerosis complex. Tuberous Sclerosis Complex: Genes, Clinical Features, and Therapeutics, Wiley-Blackwell.","DOI":"10.1002\/9783527630073"},{"key":"ref_7","first-page":"21","article-title":"Renal tumors in postmortem material","volume":"59","author":"Kozlowska","year":"2008","journal-title":"Pol. J. 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Child Neurol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/8\/369\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:51:12Z","timestamp":1760176272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/8\/369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,23]]},"references-count":14,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["medicina56080369"],"URL":"https:\/\/doi.org\/10.3390\/medicina56080369","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2020,7,23]]}}}