{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:02:40Z","timestamp":1793260960167,"version":"4.5.0"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Rhinitis could be considered a risk factor for obstructive sleep apnea (OSA). Studies were conducted to evaluate the relation between OSA and Allergic rhinitis (AR). Non-allergic rhinitis with eosinophilia syndrome (NARES) is a condition with a symptomatology apparently similar to AR. The aim of this study was to evaluate the different presence of OSA in patients suffering from NARES and AR. Materials and Methods: Sixty patients were enrolled and subdivided into NARES, AR and control groups. NARES and AR diagnosis were performed using ARIA (Allergic Rhinitis and its Impact on Asthma) protocol. All patients were screened for OSA with home sleep apnea testing (HSAT) exam analyzing AHI (Apnea Hypopnea Index) values. Results: Results showed that 60% of patients affected by NARES presented OSA. On the contrary, altered AHI was found only in 35% of patients affected by AR and in 10% of patients belonging to the control group. Conclusions: In conclusion, data showed that there was an increased risk of OSA in NARES patients respect to AR patients and healthy patients.<\/jats:p>","DOI":"10.3390\/medicina56090454","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T09:01:09Z","timestamp":1599642069000},"page":"454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Diagnosis of Obstructive Sleep Apnea in Patients with Allergic and Non-Allergic Rhinitis"],"prefix":"10.3390","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-5280","authenticated-orcid":false,"given":"Annalisa","family":"Pace","sequence":"first","affiliation":[{"name":"Organi di Senso Department, Sapienza University of Rome, Via Gregorio VII n.80, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-2809","authenticated-orcid":false,"given":"Giannicola","family":"Iannella","sequence":"additional","affiliation":[{"name":"Organi di Senso Department, Sapienza University of Rome, Via Gregorio VII n.80, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3956-2831","authenticated-orcid":false,"given":"Valeria","family":"Rossetti","sequence":"additional","affiliation":[{"name":"Organi di Senso Department, Sapienza University of Rome, Via Gregorio VII n.80, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Claudia","family":"Visconti","sequence":"additional","affiliation":[{"name":"Organi di Senso Department, Sapienza University of Rome, Via Gregorio VII n.80, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3249-5805","authenticated-orcid":false,"given":"Giampiero","family":"Gulotta","sequence":"additional","affiliation":[{"name":"Organi di Senso Department, Sapienza University of Rome, Via Gregorio VII n.80, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0378-8935","authenticated-orcid":false,"given":"Carlo","family":"Cavaliere","sequence":"additional","affiliation":[{"name":"Organi di Senso Department, Sapienza University of Rome, Via Gregorio VII n.80, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9802-7716","authenticated-orcid":false,"given":"Andrea","family":"De Vito","sequence":"additional","affiliation":[{"name":"Otorinolaringoatria Department, Santa Maria delle Croci Hospital of Ravenna, Viale Vincenzo Randi, 5, 48121 Ravenna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-0185","authenticated-orcid":false,"given":"Antonino","family":"Maniaci","sequence":"additional","affiliation":[{"name":"Otorinolaringoiatria Department, University of Catania, Piazza Universit\u00e0, 2, 95131 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cocuzza","sequence":"additional","affiliation":[{"name":"Otorinolaringoiatria Department, University of Catania, Piazza Universit\u00e0, 2, 95131 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3052-1969","authenticated-orcid":false,"given":"Giuseppe","family":"Magliulo","sequence":"additional","affiliation":[{"name":"Organi di Senso Department, Sapienza University of Rome, Via Gregorio VII n.80, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ciofalo","sequence":"additional","affiliation":[{"name":"Organi di Senso Department, Sapienza University of Rome, Via Gregorio VII n.80, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"ref_1","first-page":"255","article-title":"New Guidelines for the Treatment of Seasonal Allergic Rhinitis","volume":"36","author":"Emeryk","year":"2019","journal-title":"Postepy Derm. Alergol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaci.2010.06.047","article-title":"Allergic Rhinitis and Its Impact on Asthma (ARIA) Guidelines: 2010 Revision","volume":"126","author":"Bousquet","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11882-006-0037-0","article-title":"Non-allergic rhinitis with eosinophilia syndrome","volume":"6","author":"Ellis","year":"2006","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_4","first-page":"513","article-title":"Non-allergic rhinitis with eosinophilia syndrome a precursor of the triad: Nasal polyposis, intrinsic asthma, and intolerance to aspirin","volume":"64","author":"Hsieh","year":"1990","journal-title":"Ann. Allergy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2500\/108854185779109124","article-title":"Non allergic rhinitis: Demography of eosinophils in nasal smear, blood total eosinophil counts and IgE levels","volume":"6","author":"Settipane","year":"1985","journal-title":"N. Engl. Reg. Allergy Proc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the Global Prevalence and Burden of Obstructive Sleep Apnoea: A Literature-Based Analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitisand nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"Mullol","year":"2012","journal-title":"Rhinology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11882-002-0020-3","article-title":"Thoughts on the patho-physiology of non-allergic rhinitis","volume":"2","author":"Fokkens","year":"2002","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1001\/archinte.161.12.1514","article-title":"Chronic nasal congestion at night is a risk factor for snoring in a population-based cohort study","volume":"161","author":"Young","year":"2001","journal-title":"Arch. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00405-010-1469-7","article-title":"The role of the nose in snoring and obstructive sleep apnoea: An update","volume":"268","author":"Georgalas","year":"2011","journal-title":"Eur. Arch. Otolaryngol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic rhinitis and its impact on asthma (ARIA) guidelines-2016 revision","volume":"140","author":"Bousquet","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_12","first-page":"2724951","article-title":"Microbiota Composition and the Integration of Exogenous and Endogenous Signals in Reactive Nasal Inflammation","volume":"3","author":"Salzano","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/cea.12953","article-title":"BSACI Guideline for the Diagnosis and Management of Allergic and Non-Allergic Rhinitis (Revised Edition 2017; First Edition 2007)","volume":"47","author":"Scadding","year":"2017","journal-title":"Clin. Exp. Allergy."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5664\/jcsm.27397","article-title":"Obstructive sleep apnea syndrome and asthma: What are the links?","volume":"5","author":"Alkhalil","year":"2009","journal-title":"J. Clin. Sleep Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF00165698","article-title":"Flow-regulatory function of upper airway in health and disease: A unified pathogenetic view of sleep-disordered breathing","volume":"171","author":"Park","year":"1993","journal-title":"Lung"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1152\/jappl.1988.64.2.789","article-title":"Upper airway pressure-flow relationships in obstructive sleep apnea","volume":"64","author":"Smith","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1389-9457(02)00237-X","article-title":"The great leap forward: The anatomic basis for the acquisition of speech and obstructive sleep apnea","volume":"4","author":"Davidson","year":"2003","journal-title":"Sleep Med."},{"key":"ref_18","first-page":"625","article-title":"Obstructive apneas during sleep in patients with seasonal allergic rhinitis","volume":"126","author":"McNicholas","year":"1982","journal-title":"Am. Rev. Resp. Dis."},{"key":"ref_19","first-page":"1","article-title":"Nasal pathologies in patients with obstructive sleep apnoea patologie nasali in pazienti affetti da syndrome delle apnee ostruttive del sonno","volume":"38","author":"Magliulo","year":"2019","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"338","DOI":"10.14639\/0392-100X-1981","article-title":"Olfactory Evaluation in Obstructive Sleep Apnoea Patients","volume":"38","author":"Magliulo","year":"2018","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_21","first-page":"70","article-title":"The prevalence of allergic rhinitis in patients with simple snoring and obstructive sleep apnea syndrome","volume":"21","author":"Evren","year":"2011","journal-title":"Kulak Burun Bogaz Ihtis Derg."},{"key":"ref_22","first-page":"139","article-title":"Atopy is frequent among obstructive sleep apnoea patients undergoing skin prick testing and polysomnography in a public hospital","volume":"39","author":"Rochford","year":"2009","journal-title":"Intern. Med. J."},{"key":"ref_23","first-page":"615","article-title":"Obstructive sleep apnea and atopy among middle-aged chronic obstructive pulmonary disease and bronchial asthma patients","volume":"61","author":"Kumar","year":"2013","journal-title":"J. Assoc. Phys. India"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.4187\/respcare.03084","article-title":"Sleep apnea risk in subjects with asthma with or without comorbid rhinitis","volume":"59","author":"Braido","year":"2014","journal-title":"Respir. Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11325-016-1390-4","article-title":"Polysomnographic Findings in Persistent Allergic Rhinitis","volume":"21","author":"Bozkurt","year":"2017","journal-title":"Sleep Breath"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.amjoto.2003.12.004","article-title":"Nares: A risk factor for obstructive sleep apnea?","volume":"25","author":"Kramer","year":"2004","journal-title":"Am. J. Otolaryngol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S1081-1206(10)60138-X","article-title":"Allergic and non-allergic rhinitis: The threat for obstructive sleep apnea","volume":"103","author":"Kavut","year":"2009","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00405-012-1965-z","article-title":"The nose oropharynx hypopharynx and larynx (NOHL) classification: A new system of diagnostic standardized examination for OSAHS patients","volume":"269","author":"Vicini","year":"2012","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1007\/s00405-011-1888-0","article-title":"The effect of allergic rhinitis on the degree of stress, fatigue and quality of life in OSA patients","volume":"269","author":"Park","year":"2012","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jaci.2003.12.589","article-title":"Changes in daytime sleepiness, quality of live, and objective sleep patterns in seasonal allergic rhinitis: A controlled clinical trial","volume":"113","author":"Stuck","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_31","unstructured":"Gelardi, M. (2012). Atlas of Nasal Cytology, Edi Ermes. [2nd ed.]."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2500\/105065888781693212","article-title":"Nasal cytology in clinical practice","volume":"2","author":"Meltzer","year":"1988","journal-title":"Am. J. Rhinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1081-1206(10)62160-6","article-title":"Symptom severity assessment of allergic rhinitis: Part 1","volume":"91","author":"Spector","year":"2003","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S757","DOI":"10.1016\/S0091-6749(97)70124-6","article-title":"Nasal obstruction as a risk factor for sleep-disordered breathing","volume":"99","author":"Young","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1378\/chest.124.6.2309","article-title":"The nose and sleep-disordered breathing: What we know and what we do not know","volume":"124","author":"Rappai","year":"2003","journal-title":"Chest"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12630-010-9280-x","article-title":"A systematic review of screening questionnaires for obstructive sleep apnea","volume":"57","author":"Abrishami","year":"2010","journal-title":"Can. Anaesth"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/bja\/aes022","article-title":"High STOP-Bang indicates a high probability of obstructive sleep apnoea","volume":"108","author":"Chung","year":"2012","journal-title":"BJA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: The Epworth sleepinees scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cao, Y., Wu, S., Zhang, L., Yang, Y., Cao, S., and Li, O. (2018). Association of Allergic Rhinitis With Obstructive Sleep Apnea: A Meta-Analysis. Medicine (Baltimore), 97.","DOI":"10.1097\/MD.0000000000013783"},{"key":"ref_40","unstructured":"Berry, R.B., Brooks, R., Gamaldo, S.M., Harding, S.M., Lloyd, R.M., Marcus, C.L., and Vaughn, B.V. (2017). For the American Academy of Sleep Medicine. The AASM Manual for the Scoring of Sleep: And Associated Events: Rules, Terminology and Technical Specifications, Version 2.3, American Academy of Sleep Medicine."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/ACI.0000000000000414","article-title":"Association between allergic and nonallergic rhinitis and obstructive sleep apnea","volume":"18","author":"Zheng","year":"2018","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1016\/j.jaci.2004.12.800","article-title":"A study to determine the impact of rhinitis on sufferers\u2019 sleep and daily routine [abstract]","volume":"115","author":"Blaiss","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1001\/archinte.166.16.1744","article-title":"Allergic rhinitis and its consequences on quality of sleep: An unexplored area","volume":"166","author":"Carat","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/00016480118204","article-title":"Allergic Rhinitis Does Not Constitute a Risk Factor for Obstructive Sleep Apnea Syndrome","volume":"121","author":"Kramer","year":"2001","journal-title":"Acta Otolaryngol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1288\/00005537-199502000-00012","article-title":"Nasal inflammation in patients with obstructive sleep apnea","volume":"105","author":"Rubinstein","year":"1995","journal-title":"Laryngoscope"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"942","DOI":"10.3349\/ymj.2013.54.4.942","article-title":"Association of moderate to severe asthma with obstructive sleep apnea","volume":"54","author":"Byun","year":"2013","journal-title":"Yonsei Med. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.clim.2013.02.008","article-title":"Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis","volume":"147","author":"Thornton","year":"2013","journal-title":"Clin. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1016\/j.jaci.2004.08.044","article-title":"The correlation between allergic rhinitis and sleep disturbance","volume":"114","author":"Craig","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000336169","article-title":"Mediators and cytokines in persistent allergic rhinitis and non-allergic rhinitis with eosinophilia syndrome","volume":"159","author":"Craig","year":"2012","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2500\/ar.2014.5.0078","article-title":"Local expression of interleukin-17a is correlated with nasal eosinophilia and clinical severity in allergic rhinitis","volume":"5","author":"Makihara","year":"2014","journal-title":"Allergy Rhinol. (Providence)"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mhn.2002.125300","article-title":"Immune mediators in allergic rhinitis and sleep","volume":"126","author":"Krouse","year":"2002","journal-title":"Otolaryngol. Head Neck Surg"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.smrv.2010.12.005","article-title":"Non-invasive study of airways inflammation in sleep apnea patients","volume":"15","author":"Carpagnano","year":"2011","journal-title":"Sleep Med. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1749-6632.2001.tb05825.x","article-title":"Mediators of inflammation and their interaction with sleep. Relevance for chronic fatigue syndrome and related conditions","volume":"933","author":"Mullington","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/9\/454\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:08:06Z","timestamp":1760177286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/9\/454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,8]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["medicina56090454"],"URL":"https:\/\/doi.org\/10.3390\/medicina56090454","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,8]]}}}