{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:52:55Z","timestamp":1790646775176,"version":"4.1.0"},"reference-count":180,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Pathogens are various organisms, such as viruses, bacteria, fungi, and protozoa, which can cause severe illnesses to their hosts. Throughout history, pathogens have accompanied human populations and caused various epidemics. One of the most significant outbreaks was the Black Death, which occurred in the 14th century and caused the death of one-third of Europe\u2019s population. Pathogens have also been studied for their use as biological warfare agents by the former Soviet Union, Japan, and the USA. Among bacteria and viruses, there are high priority agents that have a significant impact on public health. Bacillus anthracis, Francisella tularensis, Yersinia pestis, Variola virus, Filoviruses (Ebola, Marburg), Arenoviruses (Lassa), and influenza viruses are included in this group of agents. Outbreaks and infections caused by them might result in social disruption and panic, which is why special operations are needed for public health preparedness. Antibiotic-resistant bacteria that significantly impede treatment and recovery of patients are also valid threats. Furthermore, recent events related to the massive spread of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are an example of how virus-induced diseases cannot be ignored. The impact of outbreaks, such as SARS-CoV-2, have had far-reaching consequences beyond public health. The economic losses due to lockdowns are difficult to estimate, but it would take years to restore countries to pre-outbreak status. For countries affected by the 2019 coronavirus disease (COVID-19), their health systems have been overwhelmed, resulting in an increase in the mortality rate caused by diseases or injuries. Furthermore, outbreaks, such as SARS-CoV-2, will induce serious, wide-ranging (and possibly long-lasting) psychological problems among, not only health workers, but ordinary citizens (this is due to isolation, quarantine, etc.). The aim of this paper is to present the most dangerous pathogens, as well as general characterizations, mechanisms of action, and treatments.<\/jats:p>","DOI":"10.3390\/medicina56110591","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T09:09:30Z","timestamp":1604653770000},"page":"591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Dangerous Pathogens as a Potential Problem for Public Health"],"prefix":"10.3390","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-002X","authenticated-orcid":false,"given":"Edyta","family":"Janik","sequence":"first","affiliation":[{"name":"Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141\/143, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6851-9536","authenticated-orcid":false,"given":"Michal","family":"Ceremuga","sequence":"additional","affiliation":[{"name":"Military Institute of Armament Technology, Prymasa Stefana Wyszy\u0144skiego 7, 05-220 Zielonka, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Niemcewicz","sequence":"additional","affiliation":[{"name":"Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141\/143, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7838-4097","authenticated-orcid":false,"given":"Michal","family":"Bijak","sequence":"additional","affiliation":[{"name":"Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141\/143, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Balloux, F., and van Dorp, L. (2017). Q&A: What are pathogens, and what have they done to and for us?. BMC Biol., 15.","DOI":"10.1186\/s12915-017-0433-z"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.resmic.2006.12.005","article-title":"Processes controlling the transmission of bacterial pathogens in the environment","volume":"158","author":"Yildiz","year":"2007","journal-title":"Res. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.vetmic.2017.02.007","article-title":"The use of animals as a surveillance tool for monitoring environmental health hazards, human health hazards and bioterrorism","volume":"203","author":"Neo","year":"2017","journal-title":"Vet. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.meegid.2019.03.022","article-title":"Comparative genomics and phylogenetic analysis of Bacillus anthracis strains isolated from domestic animals in Japan","volume":"71","author":"Okutani","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S2221-1691(11)60109-3","article-title":"Anthrax: An update","volume":"1","author":"Kamal","year":"2011","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1089\/hs.2015.0032","article-title":"Antitoxin Treatment of Inhalation Anthrax: A Systematic Review","volume":"13","author":"Huang","year":"2015","journal-title":"Health Secur."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1086\/341902","article-title":"Management of Anthrax","volume":"35","author":"Henderson","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41541-019-0102-z","article-title":"Single dose of DPX-rPA, an enhanced-delivery anthrax vaccine formulation, protects against a lethal Bacillus anthracis spore inhalation challenge","volume":"4","author":"Weir","year":"2019","journal-title":"NPJ Vaccines"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4269\/ajtmh.13-0191","article-title":"Plague gives surprises in the first decade of the 21st century in the United States and worldwide","volume":"89","author":"Butler","year":"2013","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1128\/AAC.00306-06","article-title":"Resistance of Yersinia pestis to antimicrobial agents","volume":"50","author":"Galimand","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.3201\/eid2610.191270","article-title":"Deaths Associated with Pneumonic Plague, 1946-2017","volume":"26","author":"Salam","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e01519-17","DOI":"10.1128\/JCM.01519-17","article-title":"Plague: Recognition, Treatment, and Prevention","volume":"56","author":"Yang","year":"2017","journal-title":"J. Clin. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.1073\/pnas.1900144116","article-title":"Glycoconjugate vaccine using a genetically modified O antigen induces protective antibodies to Francisella tularensis","volume":"116","author":"Stefanetti","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1473-3099(15)00355-2","article-title":"Tularaemia: Clinical aspects in Europe","volume":"16","author":"Maurin","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fcimb.2018.00154","article-title":"Live Attenuated Tularemia Vaccines for Protection against Respiratory Challenge With Virulent F. tularensis subsp. tularensis","volume":"8","author":"Jia","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/CMR.05022-11","article-title":"Predictors of mortality in Staphylococcus aureus Bacteremia","volume":"25","author":"Jensen","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8845","DOI":"10.1128\/AEM.02398-12","article-title":"Staphylococcus aureus CC398 clade associated with human-to-human transmission","volume":"78","author":"McCarthy","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3947\/ic.2016.48.4.267","article-title":"Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia","volume":"48","author":"Choo","year":"2016","journal-title":"Infect. Chemother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/21505594.2018.1426965","article-title":"A live vaccine to Staphylococcus aureus infection","volume":"9","author":"Parker","year":"2018","journal-title":"Virulence"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sow, M.S., Sow, D.C., Diallo, M.L., Kass\u00e9, D., Sylla, K., Camara, A., Djiro, S.D., Diallo, M.O.S., Bah, E.I., and Bah, I. (2019). Ebola virus disease in children in Conakry and Coyah Ebola treatment centers and risk factors associated with death. Med. Mal. Infect.","DOI":"10.1016\/j.medmal.2019.12.001"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Piszczatoski, C.R., and Gums, J.G. (2020). Ervebo (Ebola Zaire Vaccine, Live\/rVSV\u0394G-ZEBOV-GP): The First Licensed Vaccine for the Prevention of Ebola Virus Disease. J. Pharm. Technol.","DOI":"10.1177\/8755122520950692"},{"key":"ref_22","first-page":"659","article-title":"Influenza update: A review of currently available vaccines","volume":"36","author":"Clayville","year":"2011","journal-title":"Pharm. Ther. A Peer-Rev. J. Formul. Manag."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13054-019-2491-9","article-title":"Influenza virus-related critical illness: Prevention, diagnosis, treatment","volume":"23","author":"Chow","year":"2019","journal-title":"Crit. Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijid.2020.09.1464","article-title":"A systematic review and meta-analysis of published research data on COVID-19 infection fatality rates","volume":"101","author":"Merone","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e1003","DOI":"10.1016\/S2214-109X(20)30264-3","article-title":"Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: A modelling study","volume":"8","author":"Clark","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Beigel, J.H., Tomashek, K.M., Dodd, L.E., Mehta, A.K., Zingman, B.S., Kalil, A.C., Hohmann, E., Chu, H.Y., Luetkemeyer, A., and Kline, S. (2020). Remdesivir for the Treatment of Covid-19\u2014Final Report. N. Engl. J. Med.","DOI":"10.1056\/NEJMoa2007764"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"138861","DOI":"10.1016\/j.scitotenv.2020.138861","article-title":"COVID-19: Disease, management, treatment, and social impact","volume":"728","author":"Ali","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"113818","DOI":"10.1016\/j.jviromet.2020.113818","article-title":"Field-based method for assessing duration of infectivity for influenza A viruses in the environment","volume":"277","author":"Reeves","year":"2020","journal-title":"J. Virol. Methods"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ijid.2015.02.013","article-title":"Controlling Ebola: What we can learn from China\u2019s 1911 battle against the pneumonic plague in Manchuria","volume":"33","author":"Liu","year":"2015","journal-title":"Int. J. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/j.spid.2006.07.002","article-title":"Plague: A Review of its History and Potential as a Biological Weapon","volume":"17","author":"Ligon","year":"2006","journal-title":"Semin. Pediatric Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41435-019-0065-0","article-title":"Yersinia pestis and plague: An updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics","volume":"20","author":"Demeure","year":"2019","journal-title":"Genes Immun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejmech.2014.09.099","article-title":"Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox","volume":"91","author":"Oliveira","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.socscimed.2018.04.019","article-title":"The geography of smallpox in England before vaccination: A conundrum resolved","volume":"206","author":"Davenport","year":"2018","journal-title":"Soc. Sci. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1016\/j.vaccine.2019.08.038","article-title":"One of the recent attacks of smallpox in Europe: A massive vaccination campaign during the epidemic in Wroc\u0142aw in 1963","volume":"37","year":"2019","journal-title":"Vaccine"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.eeh.2012.04.003","article-title":"Smallpox and Native American mortality: The 1780s epidemic in the Hudson Bay region","volume":"49","author":"Carlos","year":"2012","journal-title":"Explor. Econ. Hist."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1016\/j.vaccine.2016.06.031","article-title":"Protection of rhesus macaques against inhalational anthrax with a Bacillus anthracis capsule conjugate vaccine","volume":"34","author":"Chabot","year":"2016","journal-title":"Vaccine"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmrp.2019.05.004","article-title":"Bioterrorism: Clinical and public health aspects of anthrax","volume":"9","author":"Chugh","year":"2019","journal-title":"Curr. Med. Res. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bsheal.2019.09.001","article-title":"Yersinia pestis, a problem of the past and a re-emerging threat","volume":"1","author":"Ditchburn","year":"2019","journal-title":"Biosaf. Health"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1046\/j.1469-0691.2002.00501.x","article-title":"Biological warfare in a historical perspective","volume":"8","author":"Roffey","year":"2002","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/1469-0691.12706","article-title":"History of biological warfare and bioterrorism","volume":"20","author":"Barras","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1039\/C8AN01488D","article-title":"A review of methods for the detection of pathogenic microorganisms","volume":"144","author":"Rajapaksha","year":"2019","journal-title":"Analyst"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.ijbiomac.2019.08.219","article-title":"Gel green fluorescence ssDNA aptasensor based on carbon nanotubes for detection of anthrax protective antigen","volume":"140","author":"Karimi","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.meegid.2013.12.014","article-title":"Exoproteome analysis of a novel strain of Bacillus cereus implicated in disease resembling cutaneous anthrax","volume":"22","author":"Ghosh","year":"2014","journal-title":"Infect. Genet. Evol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1016\/j.vaccine.2017.03.033","article-title":"A novel live attenuated anthrax spore vaccine based on an acapsular Bacillus anthracis Sterne strain with mutations in the htrA, lef and cya genes","volume":"35","author":"Chitlaru","year":"2017","journal-title":"Vaccine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bsheal.2019.12.009","article-title":"Single virus tracking of Ebola virus entry through lipid rafts in living host cells","volume":"2","author":"Jin","year":"2020","journal-title":"Biosaf. Health"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.molmed.2014.12.003","article-title":"New insights into gastrointestinal anthrax infection","volume":"21","author":"Owen","year":"2015","journal-title":"Trends Mol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tjem.2018.10.002","article-title":"Gastrointestinal and cutaneous anthrax: Case series","volume":"19","author":"Ozer","year":"2019","journal-title":"Turk. J. Emerg. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1016\/j.vaccine.2016.06.057","article-title":"Temperature-mediated recombinant anthrax protective antigen aggregate development: Implications for toxin formation and immunogenicity","volume":"34","author":"Sirota","year":"2016","journal-title":"Vaccine"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jddst.2018.07.020","article-title":"Immunogenicity of multi-walled carbon nanotubes functionalized with recombinant protective antigen domain 4 toward development of a nanovaccine against anthrax","volume":"47","author":"Karimi","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Friebe, S., van der Goot, F.G., and B\u00fcrgi, J. (2016). The Ins and Outs of Anthrax Toxin. Toxins, 8.","DOI":"10.3390\/toxins8030069"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/j.bbamem.2018.08.011","article-title":"Effect of late endosomal DOBMP lipid and traditional model lipids of electrophysiology on the anthrax toxin channel activity","volume":"1860","author":"Kalu","year":"2018","journal-title":"Biochim. Biophys. Acta Bba-Biomembr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.micinf.2011.08.016","article-title":"New insights into the biological effects of anthrax toxins: Linking cellular to organismal responses","volume":"14","author":"Guichard","year":"2012","journal-title":"Microbes Infect."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.biologicals.2019.01.001","article-title":"An ELISA using a recombinant chimera of protective antigen and lethal factor for serodiagnosis of cutaneous anthrax in India","volume":"57","author":"Varshney","year":"2019","journal-title":"Biologicals"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mbs.2018.08.010","article-title":"Modeling the macrophage-anthrax spore interaction: Implications for early host-pathogen interactions","volume":"305","author":"Pantha","year":"2018","journal-title":"Math. Biosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jtbi.2011.01.054","article-title":"Modeling the host response to inhalation anthrax","volume":"276","author":"Day","year":"2011","journal-title":"J. Theor. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Fong, I.W., and Alibek, K. (2005). Anthrax: A Disease and a Weapon. Bioterrorism and Infectious Agents: A New Dilemma for the 21st Century, Springer.","DOI":"10.1007\/b102143"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.micinf.2012.10.004","article-title":"In vivo murine and in vitro M-like cell models of gastrointestinal anthrax","volume":"15","author":"Tonry","year":"2013","journal-title":"Microbes Infect."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jiph.2010.07.004","article-title":"A review of cutaneous anthrax and its outcome","volume":"3","author":"Doganay","year":"2010","journal-title":"J. Infect. Public Health"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1016\/j.vaccine.2019.09.015","article-title":"Comparative immunogenicity and efficacy of thermostable (lyophilized) and liquid formulation of anthrax vaccine candidate AV7909","volume":"37","author":"Sanford","year":"2019","journal-title":"Vaccine"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.provac.2009.07.016","article-title":"Improvements in the Prevention and Treatment of Anthrax Infection","volume":"1","author":"Klinman","year":"2009","journal-title":"Procedia Vaccinol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6512","DOI":"10.1016\/j.vaccine.2016.06.041","article-title":"Cross-species prediction of human survival probabilities for accelerated anthrax vaccine absorbed (AVA) regimens and the potential for vaccine and antibiotic dose sparing","volume":"34","author":"Stark","year":"2016","journal-title":"Vaccine"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mcp.2010.09.002","article-title":"Detection of Yersinia pestis using real-time PCR in patients with suspected bubonic plague","volume":"25","author":"Riehm","year":"2011","journal-title":"Mol. Cell. Probes"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"101443","DOI":"10.1016\/j.jddst.2019.101443","article-title":"Development of Yersinia pestis F1 antigen-loaded liposome vaccine against plague using microneedles as a delivery system","volume":"55","author":"Chen","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tim.2015.11.008","article-title":"Pneumonic Plague: The Darker Side of Yersinia pestis","volume":"24","author":"Pechous","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.vaccine.2020.01.014","article-title":"Subcutaneous vaccination with a live attenuated Yersinia pseudotuberculosis plague vaccine","volume":"38","author":"Derbise","year":"2020","journal-title":"Vaccine"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.12688\/f1000research.8466.1","article-title":"Yersinia virulence factors - a sophisticated arsenal for combating host defences","volume":"5","author":"Atkinson","year":"2016","journal-title":"F1000Research"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3201\/eid2101.140564","article-title":"Epidemiology of human plague in the United States, 1900-2012","volume":"21","author":"Kugeler","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mbs.2018.05.013","article-title":"Plague disease model with weather seasonality","volume":"302","author":"Ngeleja","year":"2018","journal-title":"Math. Biosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.tim.2016.01.010","article-title":"A Deadly Path: Bacterial Spread During Bubonic Plague","volume":"24","author":"Gonzalez","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.epidem.2018.05.001","article-title":"The 2017 plague outbreak in Madagascar: Data descriptions and epidemic modelling","volume":"25","author":"Nguyen","year":"2018","journal-title":"Epidemics"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.medmal.2018.04.393","article-title":"Plague: Bridging gaps towards better disease control","volume":"48","author":"Brouat","year":"2018","journal-title":"Med. Mal. Infect."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"105738","DOI":"10.1016\/j.mimet.2019.105738","article-title":"Rapid viability polymerase chain reaction method for detection of Francisella tularensis","volume":"166","author":"Kane","year":"2019","journal-title":"J. Microbiol. Methods"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"101322","DOI":"10.1016\/j.ttbdis.2019.101322","article-title":"Genetic diversity of Francisella tularensis in Poland with comments on MLVA genotyping and a proposition of a novel rapid v4-genotyping","volume":"11","author":"Brodzik","year":"2020","journal-title":"Ticks Tick-Borne Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jiph.2019.12.007","article-title":"A rare cause of granulomatous hepatitis: Tularemia","volume":"13","author":"Doran","year":"2020","journal-title":"J. Infect. Public Health"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"101379","DOI":"10.1016\/j.cimid.2019.101379","article-title":"A serological and molecular study on Francisella tularensis in rodents from Hamadan province, Western Iran","volume":"68","author":"Hemati","year":"2020","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ijid.2019.04.031","article-title":"Clinical characteristics in a sentinel case as well as in a cluster of tularemia patients associated with grape harvest","volume":"84","author":"Wetzstein","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.micinf.2013.12.003","article-title":"The contribution of the glycine cleavage system to the pathogenesis of Francisella tularensis","volume":"16","author":"Brown","year":"2014","journal-title":"Microbes Infect."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.vetmic.2009.07.017","article-title":"Tularemia","volume":"140","author":"Foley","year":"2010","journal-title":"Vet. Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.micinf.2013.09.009","article-title":"Francisella tularensis intracellular survival: To eat or to die","volume":"15","author":"Barel","year":"2013","journal-title":"Microbes Infect."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.ttbdis.2016.07.016","article-title":"Cluster of ulceroglandular tularemia cases in Slovenia","volume":"7","author":"Rojko","year":"2016","journal-title":"Ticks Tick-Borne Dis."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Fong, I.W., and Alibek, K. (2005). Tularemia and Bioterrorism. Bioterrorism and Infectious Agents: A New Dilemma for the 21st Century, Springer.","DOI":"10.1007\/b102143"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tmaid.2014.10.007","article-title":"An overview: Tularemia and travel medicine","volume":"12","author":"Doganay","year":"2014","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1016\/j.vaccine.2017.10.053","article-title":"Protection of vaccinated mice against pneumonic tularemia is associated with an early memory sentinel-response in the lung","volume":"35","author":"Cohen","year":"2017","journal-title":"Vaccine"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ajpath.2016.09.021","article-title":"The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4","volume":"187","author":"Hutt","year":"2017","journal-title":"Am. J. Pathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.amjms.2018.06.006","article-title":"From Squirrels to Biological Weapons: The Early History of Tularemia","volume":"356","author":"Hirschmann","year":"2018","journal-title":"Am. J. Med. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.idc.2009.10.012","article-title":"Tularemia Pneumonia","volume":"24","author":"Thomas","year":"2010","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijid.2018.03.023","article-title":"A case of typhoidal tularemia in a male Japanese farmer","volume":"71","author":"Nakamura","year":"2018","journal-title":"Int. J. Infect. Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.anl.2010.12.007","article-title":"Three cases of oropharyngeal tularemia in Turkey","volume":"38","author":"Ugur","year":"2011","journal-title":"Auris Nasus Larynx"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jobcr.2019.12.002","article-title":"Nasal conveyance of Methicillin-resistant Staphylococcus aureus (MRSA) strains among dental professionals with varying levels of clinical exposure: A comparative study","volume":"10","author":"Rao","year":"2019","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"151004","DOI":"10.1016\/j.tetlet.2019.151004","article-title":"Synthesis and antibacterial activity of emodin and its derivatives against methicillin-resistant Staphylococcus aureus","volume":"60","author":"Chalothorn","year":"2019","journal-title":"Tetrahedron Lett."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"100028","DOI":"10.1016\/j.infpip.2019.100028","article-title":"Reducing transmission of methicillin-resistant Staphylococcus aureus in a surgical ward of a resource-limited hospital in Indonesia: An intervention study","volume":"1","author":"Santosaningsih","year":"2019","journal-title":"Infect. Prev. Pract."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"100454","DOI":"10.1016\/j.genrep.2019.100454","article-title":"Distribution of SCCmec types, tetracycline and aminoglycoside resistance genes in hospital-associated methicillin-resistant Staphylococcus aureus strains","volume":"16","author":"Goudarzi","year":"2019","journal-title":"Gene Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jiac.2018.03.004","article-title":"Change in genotype of methicillin-resistant Staphylococcus aureus (MRSA) affects the antibiogram of hospital-acquired MRSA","volume":"24","author":"Harada","year":"2018","journal-title":"J. Infect. Chemother."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jiph.2019.01.063","article-title":"Absence of the mecC gene in methicillin-resistant Staphylococcus aureus isolated from various clinical samples: The first multi-centered study in Turkey","volume":"12","author":"Cikman","year":"2019","journal-title":"J. Infect. Public Health"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.meegid.2018.01.018","article-title":"Evolution of methicillin-resistant Staphylococcus aureus: Evidence of positive selection in a penicillin-binding protein (PBP) 2a coding gene mecA","volume":"59","author":"Zhan","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Singh-Moodley, A., Strasheim, W., Mogokotleng, R., Ismail, H., and Perovic, O. (2019). Unconventional SCCmec types and low prevalence of the Panton-Valentine Leukocidin exotoxin in South African blood culture Staphylococcus aureus surveillance isolates, 2013\u20132016. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0225726"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.meegid.2018.03.013","article-title":"Novel SCCmec type XIII (9A) identified in an ST152 methicillin-resistant Staphylococcus aureus","volume":"61","author":"Baig","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jgar.2018.08.013","article-title":"Prevalence of methicillin-resistant Staphylococcus aureus colonisation among healthcare workers at a tertiary care hospital in southeastern China","volume":"15","author":"Kong","year":"2018","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mbs.2019.01.013","article-title":"Optimal control of environmental cleaning and antibiotic prescription in an epidemiological model of methicillin-resistant Staphylococcus aureus infections in hospitals","volume":"311","author":"Huang","year":"2019","journal-title":"Math. Biosci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.sjbs.2018.03.006","article-title":"Methicillin-resistant Staphylococcus aureus (MRSA) screening of hospital dental clinic surfaces","volume":"26","author":"Faden","year":"2019","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"106246","DOI":"10.1016\/j.buildenv.2019.106246","article-title":"The dynamic fomite transmission of Methicillin-resistant Staphylococcus aureus in hospitals and the possible improved intervention methods","volume":"161","author":"Xiao","year":"2019","journal-title":"Build. Environ."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"105827","DOI":"10.1016\/j.ijantimicag.2019.10.008","article-title":"Efficacy of newly generated short antimicrobial cationic lipopeptides against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"55","author":"Greber","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"102375","DOI":"10.1016\/j.jaut.2019.102375","article-title":"Ebola virus disease: An emerging and re-emerging viral threat","volume":"106","author":"Rojas","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S2221-1691(15)30365-8","article-title":"Ebola virus disease: Past, present and future","volume":"5","author":"Rajak","year":"2015","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.idc.2019.08.005","article-title":"Ebola Virus Disease: Epidemiology, Clinical Features, Management, and Prevention","volume":"33","author":"Nicastri","year":"2019","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1073\/pnas.1120453109","article-title":"Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography","volume":"109","author":"Bharat","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1016\/j.celrep.2019.08.047","article-title":"A VP35 Mutant Ebola Virus Lacks Virulence but Can Elicit Protective Immunity to Wild-Type Virus Challenge","volume":"28","author":"Woolsey","year":"2019","journal-title":"Cell Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jtbi.2019.01.013","article-title":"Assessing the effects of modeling the spectrum of clinical symptoms on the dynamics and control of Ebola","volume":"467","author":"Ponce","year":"2019","journal-title":"J. Theor. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/j.bmcl.2017.04.028","article-title":"Recent progress on the treatment of Ebola virus disease with Favipiravir and other related strategies","volume":"27","author":"Zhang","year":"2017","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.idc.2018.10.013","article-title":"Evidence-Based Clinical Management of Ebola Virus Disease and Epidemic Viral Hemorrhagic Fevers","volume":"33","author":"Adhikari","year":"2019","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"100371","DOI":"10.1016\/j.epidem.2019.100371","article-title":"Accurate forecasts of the effectiveness of interventions against Ebola may require models that account for variations in symptoms during infection","volume":"29","author":"Hart","year":"2019","journal-title":"Epidemics"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"841","DOI":"10.12980\/APJTB.4.201414B420","article-title":"Key features of Ebola hemorrhagic fever: A review","volume":"4","author":"Sousa","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(16)32621-6","article-title":"Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: Final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola \u00c7a Suffit!)","volume":"389","author":"Camacho","year":"2017","journal-title":"Lancet"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1056\/NEJMoa1504874","article-title":"Clinical Management of Ebola Virus Disease in the United States and Europe","volume":"374","author":"Uyeki","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"925","DOI":"10.12980\/APJTB.4.201414B448","article-title":"Ebola: A review on the state of the art on prevention and treatment","volume":"4","author":"Torre","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev.pathmechdis.3.121806.154316","article-title":"The pathology of influenza virus infections","volume":"3","author":"Taubenberger","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1097\/CCM.0b013e318180b039","article-title":"Influenza","volume":"36","author":"Beigel","year":"2008","journal-title":"Crit. Care Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"108548","DOI":"10.1016\/j.clim.2020.108548","article-title":"The cellular immunophenotype expression of influenza A virus and influenza B virus infection in children","volume":"219","author":"Shen","year":"2020","journal-title":"Clin. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Yu, J., Zhao, S., and Rao, H. (2020). Whole-genome sequences of two influenza A (H3N2) virus strains isolated from Qinghai, China. Biosaf. Health.","DOI":"10.1016\/j.bsheal.2020.09.005"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/irv.12062","article-title":"Influenza C virus\u2013associated community-acquired pneumonia in children","volume":"7","author":"Principi","year":"2013","journal-title":"Influenza Other Respir. Viruses"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41572-018-0002-y","article-title":"Influenza","volume":"4","author":"Krammer","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.3389\/fimmu.2018.01581","article-title":"Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement","volume":"9","author":"Dou","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"D49","DOI":"10.1016\/j.vaccine.2008.07.039","article-title":"The biology of influenza viruses","volume":"26","author":"Bouvier","year":"2008","journal-title":"Vaccine"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.vetmic.2009.08.022","article-title":"(Highly pathogenic) avian influenza as a zoonotic agent","volume":"140","author":"Kalthoff","year":"2010","journal-title":"Vet. Microbiol."},{"key":"ref_125","first-page":"4","article-title":"Avian influenza--a pandemic waiting to happen?","volume":"39","author":"Liu","year":"2006","journal-title":"J. Microbiol. Immunol. Infect. Wei Mian Yu Gan Ran Za Zhi"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11262-009-0404-8","article-title":"An update on swine-origin influenza virus A\/H1N1: A review","volume":"39","author":"Schnitzler","year":"2009","journal-title":"Virus Genes"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/irv.12080","article-title":"Routes of influenza transmission","volume":"7","author":"Killingley","year":"2013","journal-title":"Influenza Other Respir. Viruses"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e1952","DOI":"10.1097\/MD.0000000000001952","article-title":"Predictive Symptoms and Signs of Laboratory-confirmed Influenza: A Prospective Surveillance Study of Two Metropolitan Areas in Taiwan","volume":"94","author":"Yang","year":"2015","journal-title":"Medicine"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12985-015-0448-4","article-title":"Prevalence of gastrointestinal symptoms in patients with influenza, clinical significance, and pathophysiology of human influenza viruses in faecal samples: What do we know?","volume":"12","author":"Minodier","year":"2015","journal-title":"Virol. J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/irv.12470","article-title":"The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection","volume":"11","author":"Sellers","year":"2017","journal-title":"Influenza Other Respir. Viruses"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"i6258","DOI":"10.1136\/bmj.i6258","article-title":"Influenza","volume":"355","author":"Ghebrehewet","year":"2016","journal-title":"BMJ"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fped.2019.00317","article-title":"Influenza Vaccination: Effectiveness, Indications, and Limits in the Pediatric Population","volume":"7","author":"Mameli","year":"2019","journal-title":"Front. Pediatrics"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e01914","DOI":"10.7554\/eLife.01914","article-title":"Integrating influenza antigenic dynamics with molecular evolution","volume":"3","author":"Bedford","year":"2014","journal-title":"eLife"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12929-020-0626-6","article-title":"Better influenza vaccines: An industry perspective","volume":"27","author":"Chen","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jhin.2020.05.017","article-title":"Detection of SARS-CoV-2 on high-touch surfaces in a clinical microbiology laboratory","volume":"105","author":"Bloise","year":"2020","journal-title":"J. Hosp. Infect."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.dsx.2020.04.020","article-title":"Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response","volume":"14","author":"Astuti","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41401-020-0485-4","article-title":"Structural and functional properties of SARS-CoV-2 spike protein: Potential antivirus drug development for COVID-19","volume":"41","author":"Huang","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"165878","DOI":"10.1016\/j.bbadis.2020.165878","article-title":"Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach","volume":"1866","author":"Naqvi","year":"2020","journal-title":"Biochim. Biophys. Acta Bba-Mol. Basis Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature17200","article-title":"Pre-fusion structure of a human coronavirus spike protein","volume":"531","author":"Kirchdoerfer","year":"2016","journal-title":"Nature"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein","volume":"181","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"118056","DOI":"10.1016\/j.lfs.2020.118056","article-title":"Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination","volume":"257","author":"Sternberg","year":"2020","journal-title":"Life Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.bbrc.2020.04.136","article-title":"Biochemical characterization of SARS-CoV-2 nucleocapsid protein","volume":"527","author":"Zeng","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.virol.2007.05.032","article-title":"Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway","volume":"368","author":"Ortego","year":"2007","journal-title":"Virology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12985-019-1182-0","article-title":"Coronavirus envelope protein: Current knowledge","volume":"16","author":"Schoeman","year":"2019","journal-title":"Virol. J."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jsb.2010.11.021","article-title":"A structural analysis of M protein in coronavirus assembly and morphology","volume":"174","author":"Neuman","year":"2011","journal-title":"J. Struct. Biol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"15917","DOI":"10.1038\/s41598-020-72528-z","article-title":"Structural and functional modelling of SARS-CoV-2 entry in animal models","volume":"10","author":"Brooke","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.3389\/fimmu.2020.01949","article-title":"Overview of Immune Response during SARS-CoV-2 Infection: Lessons From the Past","volume":"11","author":"Shah","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_149","first-page":"11","article-title":"The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak-an update on the status","volume":"7","author":"Guo","year":"2020","journal-title":"Mil. Med. Res."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Rabi, F.A., Al Zoubi, M.S., Kasasbeh, G.A., Salameh, D.M., and Al-Nasser, A.D. (2020). SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far. Pathogens, 9.","DOI":"10.3390\/pathogens9030231"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"101623","DOI":"10.1016\/j.tmaid.2020.101623","article-title":"Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis","volume":"34","year":"2020","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41591-020-0968-3","article-title":"Extrapulmonary manifestations of COVID-19","volume":"26","author":"Gupta","year":"2020","journal-title":"Nat. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.kint.2020.03.005","article-title":"Kidney disease is associated with in-hospital death of patients with COVID-19","volume":"97","author":"Cheng","year":"2020","journal-title":"Kidney Int."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.kint.2020.05.006","article-title":"Northwell COVID-19 research consortium; northwell nephrology COVID-19 research consortium. Acute kidney injury in patients hospitalized with COVID-19","volume":"98","author":"Hirsch","year":"2020","journal-title":"Kidney Int."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S2468-1253(20)30126-6","article-title":"Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: A systematic review and meta-analysis","volume":"5","author":"Mao","year":"2020","journal-title":"Lancet. Gastroenterol. Hepatol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"766","DOI":"10.14309\/ajg.0000000000000620","article-title":"Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study","volume":"115","author":"Pan","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/cld.969","article-title":"Potential Treatments for SARS-CoV-2 Infection","volume":"15","author":"Berry","year":"2020","journal-title":"Clin. Liver Dis."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"9490","DOI":"10.1073\/pnas.2004168117","article-title":"Effectiveness of convalescent plasma therapy in severe COVID-19 patients","volume":"117","author":"Duan","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.ajpath.2020.05.014","article-title":"Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma","volume":"190","author":"Salazar","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cimid.2019.02.004","article-title":"Comprehensive literature review of the sources of infection and transmission routes of Coxiella burnetii, with particular regard to the criteria of \u201cevidence-based medicine\u201d","volume":"64","author":"Koehler","year":"2019","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_163","first-page":"30048","article-title":"The consequences of human actions on risks for infectious diseases: A review","volume":"5","author":"Lindahl","year":"2015","journal-title":"Infect. Ecol. Epidemiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.micpath.2019.05.021","article-title":"In vitro and in silico approaches of antibiofilm activity of 1-hydroxy-1-norresistomycin against human clinical pathogens","volume":"132","author":"Ramalingam","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"125032","DOI":"10.1016\/j.chemosphere.2019.125032","article-title":"Association between antibiotic residues, antibiotic resistant bacteria and antibiotic resistance genes in anthropogenic wastewater\u2014An evaluation of clinical influences","volume":"241","author":"Voigt","year":"2020","journal-title":"Chemosphere"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.chemosphere.2015.12.084","article-title":"A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes","volume":"150","author":"Sharma","year":"2016","journal-title":"Chemosphere"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: The WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"127859","DOI":"10.1016\/j.snb.2020.127859","article-title":"Exhaled air analysis as a potential fast method for early diagnosis of dengue disease","volume":"310","author":"Welearegay","year":"2020","journal-title":"Sens. Actuators B Chem."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"105114","DOI":"10.1016\/j.actatropica.2019.105114","article-title":"First report on the transmission of Zika virus by Aedes (Stegomyia) aegypti (L.) (Diptera: Culicidae) during the 2018 Zika outbreak in India","volume":"199","author":"Singh","year":"2019","journal-title":"Acta Trop."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.imbio.2017.10.040","article-title":"Human monoclonal antibodies neutralizing influenza virus A\/H1N1pdm09 and seasonal A\/H1N1 strains\u2013Distinct Ig gene repertoires with a similar action mechanism","volume":"223","author":"Hiroi","year":"2018","journal-title":"Immunobiology"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"197885","DOI":"10.1016\/j.virusres.2020.197885","article-title":"Host microRNAs and exosomes that modulate influenza virus infection","volume":"279","author":"Zheng","year":"2020","journal-title":"Virus Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jcv.2017.12.012","article-title":"An epidemic surge of influenza A(H3N2) virus at the end of the 2016\u20132017 season in Taiwan with an increased viral genetic heterogeneity","volume":"99\u2013100","author":"Yang","year":"2018","journal-title":"J. Clin. Virol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.glohj.2019.09.003","article-title":"What we have learnt from the SARS epdemics in mainland China?","volume":"3","author":"Cao","year":"2019","journal-title":"Glob. Health J."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.amc.2013.12.062","article-title":"Numerical study of SARS epidemic model with the inclusion of diffusion in the system","volume":"229","author":"Naheed","year":"2014","journal-title":"Appl. Math. Comput."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.meegid.2019.03.001","article-title":"Molecular epidemiology, evolution and phylogeny of SARS coronavirus","volume":"71","author":"Luk","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Degnah, A.A., Al-amri, S.S., Hassan, A.M., Almasoud, A.S., Mousa, M., Almahboub, S.A., Alhabbab, R.Y., Mirza, A.A., Hindawi, S.I., and Alharbi, N.K. (2020). Seroprevalence of MERS-CoV in healthy adults in western Saudi Arabia, 2011\u20132016. J. Infect. Public Health.","DOI":"10.2139\/ssrn.3409306"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"197863","DOI":"10.1016\/j.virusres.2020.197863","article-title":"Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein","volume":"278","author":"Goo","year":"2020","journal-title":"Virus Res."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"105924","DOI":"10.1016\/j.ijantimicag.2020.105924","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges","volume":"55","author":"Lai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Chen, J. (2020). Pathogenicity and transmissibility of 2019-nCoV\u2014A quick overview and comparison with other emerging viruses. Microbes Infect.","DOI":"10.1016\/j.micinf.2020.01.004"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/11\/591\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:30:07Z","timestamp":1760178607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/11\/591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,6]]},"references-count":180,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["medicina56110591"],"URL":"https:\/\/doi.org\/10.3390\/medicina56110591","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,6]]}}}