{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:08:51Z","timestamp":1768619331712,"version":"3.49.0"},"reference-count":64,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Irritable bowel syndrome (IBS) is a gastrointestinal disease that negatively affects up to 20% of the population. Infertility is defined as a disorder of the reproductive system described by lack of success in achieving pregnancy after more than a year of regular unprotected sexual intercourse. The main purpose of our review was to analyze the available literature regarding the IBS-infertility connection. Another secondary purpose of the present paper was to find out if oxidative stress may be the missing puzzle that may explain this possible correlation. After analyzing the available literature we concluded that oxidative stress is a plausible mediator of the connection between both female and male fertility and IBS. However, the data lacks in direct evidence to confirm this hypothesis. Nevertheless, it is recommended that certain levels of oxidative stress should not be exceeded in order to decrease IBS symptoms and increase the odds of conception given that generation of reactive oxygen species (ROS) is an aftermath of metabolically active cells. Therefore, reducing the oxidative stress by living a healthier lifestyle with a balanced diet, rich in micronutrients, limited in caffeine and alcohol, avoiding smoking and maintaining a normal body mass index with regular physical exercise may promote fertility and help diminishing IBS symptomatology. Studies with measurements of biological samples are needed in order to assess the complex relationship between oxidative stress, IBS and infertility.<\/jats:p>","DOI":"10.3390\/medicina56110592","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T09:03:04Z","timestamp":1604653384000},"page":"592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Review of the Complex Relationship between Irritable Bowel Syndrome and Infertility"],"prefix":"10.3390","volume":"56","author":[{"given":"Carmen","family":"Anton","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 6th University Street, 700490 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alin","family":"Ciobica","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, \u201cAlexandru Ioan Cuza\u201d University of Iasi, Carol I Avenue, 20A, 700490 Iasi, Romania"},{"name":"Department Center of Biomedical Research, Romanian Academy, Iasi Branch, Nr. 8, Carol I Avenue, No. 8, 700490 Iasi, Romania"},{"name":"Department of Biology, Academy of Romanian Scientists, Splaiul Independentei Nr. 54, Sector 5, 050094 Bucuresti, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6618-141X","authenticated-orcid":false,"given":"Bogdan","family":"Doroftei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 6th University Street, 700490 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu","family":"Maftei","sequence":"additional","affiliation":[{"name":"Clinical Department, Origyn Fertility Center, Palace Street, No 3C, 700032 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciprian","family":"Ilea","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 6th University Street, 700490 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3882-2558","authenticated-orcid":false,"given":"Natalia","family":"Darii Plopa","sequence":"additional","affiliation":[{"name":"Department of of Obstetrics and Gynecology, Grand H\u00f4pital De Charleroi, Avenue du Centenaries 73, 6061 Charleroi, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bolota","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Spitalul Clinic de Obstetric\u0103 \u0219i Ginecologie Cuza Vod\u0103, 700032 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8244-0522","authenticated-orcid":false,"given":"Emil","family":"Anton","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, \u201cGr. T. Popa\u201d University of Medicine and Pharmacy, 6th University Street, 700490 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.23736\/S0031-0808.18.03541-3","article-title":"Irritable bowel syndrome: The clinical approach","volume":"60","author":"Adriani","year":"2018","journal-title":"Panminerva Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Balmus, I.-M., Ilie-Dumitru, O., Ciobica, A., Cojocariu, R.-O., Stanciu, C., Trifan, A., Cimpeanu, M., Cimpeanu, C., and Gorgan, L. (2020). Irritable Bowel Syndrome between Molecular Approach and Clinical Expertise\u2014Searching for Gap Fillers in the Oxidative Stress Way of Thinking. Medicina, 56.","DOI":"10.3390\/medicina56010038"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.3748\/wjg.v18.i37.5151","article-title":"Irritable bowel syndrome: Diagnosis and pathogenesis","volume":"18","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/0016-5085(81)90263-8","article-title":"Gastrointestinal transit: The effect of the menstrual cycle","volume":"80","author":"Wald","year":"1981","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1365-2982.2006.00808.x","article-title":"Effect of female sex hormone supplementation and withdrawal on gastrointestinal and colonic transit in postmenopausal women","volume":"18","author":"Gonenne","year":"2006","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0016-5085(95)90373-9","article-title":"Irritable bowel syndrome and dyspepsia in the general population: Overlap and lack of stability over time","volume":"109","author":"Tibblin","year":"1995","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2796.1994.tb01115.x","article-title":"The epidemiology of irritable bowel syndrome in a random population: Prevalence, incidence, natural history and risk factors","volume":"236","author":"Kay","year":"1994","journal-title":"J. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/apt.12080","article-title":"Review article: Associations between immune activation, intestinal permeability and the irritable bowel syndrome","volume":"36","author":"Matricon","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"CR493","DOI":"10.12659\/MSM.883269","article-title":"Autonomic nervous system activity in constipation-predominant irritable bowel syndrome patients","volume":"18","author":"Mazur","year":"2012","journal-title":"Med Sci. Monit."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and infertility: Definition and epidemiology","volume":"62","author":"Borght","year":"2018","journal-title":"Clin. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1001\/archinte.164.20.2283","article-title":"Antisperm Antibodies in Inflammatory Bowel Disease","volume":"164","author":"Rossato","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s003840050093","article-title":"The effects of chronic ill health and treatment with sulphasalazine on fertility amongst men and women with inflammatory bowel disease in Leicestershire","volume":"12","author":"Moody","year":"1997","journal-title":"Int. J. Color. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/00004836-198908000-00011","article-title":"Male Infertility in Inflammatory Bowel Disease","volume":"11","author":"Narendranathan","year":"1989","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000201046","article-title":"Perceived Sexual Dysfunction amongst Patients with Inflammatory Bowel Disease","volume":"54","author":"Moody","year":"1993","journal-title":"Digestion"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2036.2007.03397.x","article-title":"Review article: Reproduction in the patient with inflammatory bowel disease","volume":"26","author":"Heetun","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/apt.12478","article-title":"Systematic review: Fertility in non-surgically treated inflammatory bowel disease","volume":"38","author":"Tavernier","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Lee, S., Crowe, M., Seow, C.H., Kotze, P.G., Kaplan, G.G., Metcalfe, A., Ricciuto, A., Benchimol, E.I., and Kuenzig, M.E. (2019). The impact of surgical therapies for inflammatory bowel disease on female fertility. Cochrane Database Syst. Rev., 7.","DOI":"10.1002\/14651858.CD012711.pub2"},{"key":"ref_18","first-page":"768","article-title":"Sexual and reproductive issues for men with inflammatory bowel disease","volume":"104","author":"Feagins","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/apt.13142","article-title":"Review article: The safety of therapeutic drugs in male inflammatory bowel disease patients wishing to conceive","volume":"41","author":"Sands","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/19396368.2014.952391","article-title":"Inflammatory bowel disease in subfertile men and the effect of mesalazine on fertility","volume":"60","author":"Shin","year":"2014","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000251036","article-title":"Studies on Human Semen in Topical Corticosteroid-Treated and in Methotrexate-Treated Psoriatics","volume":"154","author":"Grunnet","year":"1977","journal-title":"Dermatologica"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4292\/wjgpt.v7.i3.361","article-title":"Infertility in men with inflammatory bowel disease","volume":"7","author":"Shin","year":"2016","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"ref_23","first-page":"267","article-title":"Managing Reduced Fecundity Following IBD-related Surgery","volume":"4","author":"Johnson","year":"2008","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.dld.2006.05.009","article-title":"Irritable bowel syndrome: The burden and unmet needs in Europe","volume":"38","author":"Quigley","year":"2006","journal-title":"Dig. Liver Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.fertnstert.2009.09.009","article-title":"International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009","volume":"92","author":"Adamson","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.med.45.1.391","article-title":"Gonadotropin-releasing hormone and its analogs","volume":"45","author":"Conn","year":"1994","journal-title":"Annu. Rev. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1095\/biolreprod56.2.293","article-title":"New concepts of the neuroendocrine regulation of gonadotropin surges in rats","volume":"56","author":"Levine","year":"1997","journal-title":"Biol. Reprod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.yfrne.2004.06.001","article-title":"Ontogeny of GnRH and olfactory neuronal systems in man: Novel insights from the investigation of inherited forms of Kallmann\u2019s syndrome","volume":"25","author":"Hu","year":"2004","journal-title":"Front. Neuroendocr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1530\/rep.1.00066","article-title":"Neural transplantation in hypogonadal (hpg) mice\u2014Physiology and neurobiology","volume":"127","author":"Charlton","year":"2004","journal-title":"Reprod."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3109\/00365521.2012.706826","article-title":"Depletion of enteric gonadotropin-releasing hormone is found in a few patients suffering from severe gastrointestinal dysmotility","volume":"47","author":"Hammar","year":"2012","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/1319-3767.173753","article-title":"The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models","volume":"22","author":"Balmus","year":"2016","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_32","first-page":"194","article-title":"The effects of short-term nicotine administration on behavioral and oxidative stress deficiencies induced in a rat model of Parkinson\u2019s disease","volume":"24","author":"Ciobica","year":"2012","journal-title":"Psychiatr. Danub."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.placenta.2008.11.019","article-title":"Effect of Increasing Maternal Body Mass Index on Oxidative and Nitrative Stress in The Human Placenta","volume":"30","author":"Roberts","year":"2008","journal-title":"Placenta"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic Ovary Syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.fertnstert.2003.08.023","article-title":"A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome","volume":"81","author":"Stamets","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1055\/s-2007-992928","article-title":"Dietary Therapy in Polycystic Ovary Syndrome","volume":"26","author":"Moran","year":"2008","journal-title":"Semin. Reprod. Med."},{"key":"ref_37","first-page":"337","article-title":"Zinc deficiency in men with Crohn\u2019s disease may contribute to poor sperm function and male infertility","volume":"35","year":"2003","journal-title":"Andrologia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1053\/j.gastro.2006.10.036","article-title":"Chronic Intestinal Pseudo-Obstruction due to Buserelin-Induced Formation of Anti-GnRH Antibodies","volume":"132","author":"Ohlsson","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0090-4295(96)00313-5","article-title":"Role of reactive oxygen species in male infertility","volume":"48","author":"Sharma","year":"1996","journal-title":"Urology"},{"key":"ref_40","unstructured":"Lipschultz, L.Y., and Howards, S.S. (1983). Evaluation of the subferttile man. Infertility in the Male, Churchill Livingstone."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1530\/jrf.0.0730441","article-title":"Relationship between the movement characteristics of human spermatozoa and their ability to penetrate cervical mucus and zona-free hamster oocytes","volume":"73","author":"Aitken","year":"1985","journal-title":"J. Reprod. Fertil."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0015-0282(16)44720-5","article-title":"Penetration of Human Spermatozoa into the Human Zona Pellucida and the Zona-Free Hamster Egg: A Study of Fertile Donors and Infertile Patients","volume":"33","author":"Overstreet","year":"1980","journal-title":"Fertil. Steril."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0015-0282(16)46398-3","article-title":"The correlates of fertilizing capacity in normal fertile men","volume":"38","author":"Aitken","year":"1982","journal-title":"Fertil. Steril."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1095\/biolreprod27.5.1109","article-title":"Production of Superoxide and Activity of Superoxide Dismutase in Rabbit Epididymal Spermatozoa","volume":"27","author":"Holland","year":"1982","journal-title":"Biol. Reprod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0015-0282(16)46698-7","article-title":"An analysis of semen quality and sperm function in cases of oligozoospermia","volume":"38","author":"Aitken","year":"1982","journal-title":"Fertil. Steril."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1530\/jrf.0.0810459","article-title":"Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa","volume":"81","author":"Aitken","year":"1987","journal-title":"Reproduction"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/j.1939-4640.1987.tb00973.x","article-title":"Spontaneous Lipid Peroxidation and Production of Hydrogen Peroxide and Superoxide in Human Spermatozoa Superoxide Dismutase as Major Enzyme Protectant Against Oxygen Toxicity","volume":"8","author":"Alvarez","year":"1987","journal-title":"J. Androl."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.fertnstert.2019.11.008","article-title":"The effect of antioxidants on male factor infertility: The Males, Antioxidants, and Infertility (MOXI) randomized clinical trial","volume":"113","author":"Steiner","year":"2020","journal-title":"Fertil. Steril."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/GCO.0b013e32832924ba","article-title":"Impact of oxidative stress on female fertility","volume":"21","author":"Ruder","year":"2009","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_50","unstructured":"Dormandy, T., and Rice-Evans, C. (1987). Generation of reactive oxygen species by human spermatozoa. Free Radicals: Recent Developments in Lipid Chemistry, Experimental Pathology and Medicine, Richelieu Press."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1477-7827-3-28","article-title":"Role of oxidative stress in female reproduction","volume":"3","author":"Agarwal","year":"2005","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S1472-6483(10)61641-0","article-title":"Role of antioxidants in treatment of male infertility: An overview of the literature","volume":"8","author":"Agarwal","year":"2004","journal-title":"Reprod. Biomed. Online"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0015-0282(03)00266-8","article-title":"Oxidative stress may be a piece in the endometriosis puzzle","volume":"79","author":"Szczepanska","year":"2003","journal-title":"Fertil. Steril."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0015-0282(02)04948-8","article-title":"Role of reactive oxygen species in the pathophysiology of human reproduction","volume":"79","author":"Agarwal","year":"2003","journal-title":"Fertil. Steril."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1258\/ebm.2011.011358","article-title":"Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: Updated experimental and clinical evidence","volume":"237","author":"Zhu","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"762","DOI":"10.12659\/MSM.889068","article-title":"The role of oxidants and reactive nitrogen species in irritable bowel syndrome: A potential etiological explanation","volume":"19","author":"Gurel","year":"2013","journal-title":"Med. Sci. Monit."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S1542-3565(05)00410-6","article-title":"A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome","volume":"3","author":"Isaksson","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/j.1365-2036.2011.04624.x","article-title":"Altered peripheral toll-like receptor responses in the irritable bowel syndrome","volume":"33","author":"McKernan","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1365-2982.2009.01272.x","article-title":"B-cell activation in patients with irritable bowel syndrome (IBS)","volume":"21","author":"Lindmark","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"C1408","DOI":"10.1152\/ajpcell.00073.2005","article-title":"Production of IL-1\u03b2, hydrogen peroxide, and nitric oxide by colonic mucosa decreases sigmoid smooth muscle contractility in ulcerative colitis","volume":"289","author":"Cao","year":"2005","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1165\/ajrcmb.12.4.7695923","article-title":"Xanthine oxidase-derived oxygen radicals increase lung cytokine expression in mice subjected to hemorrhagic shock","volume":"12","author":"Schwartz","year":"1995","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/jbmr.5650071005","article-title":"Release of oxygen radicals by articular chondrocytes: A study of luminol-dependent chemiluminescence and hydrogen peroxide secretion","volume":"7","author":"Rathakrishnan","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/jcb.10428","article-title":"Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induced NF-jB activation and iNOS expression in bovine articular chondrocytes","volume":"88","author":"Mendes","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3389\/fendo.2018.00725","article-title":"Endometriosis Is a Cause of Infertility. Does Reactive Oxygen Damage to Gametes and Embryos Play a Key Role in the Pathogenesis of Infertility Caused by Endometriosis?","volume":"9","author":"Bernstein","year":"2018","journal-title":"Front Endocrinol. 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