{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:59:23Z","timestamp":1787605163664,"version":"build-2736575974"},"reference-count":18,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: prurigo is a chronic skin disorder associated with a history of chronic pruritus. The pathogenesis of prurigo is largely unknown and the treatment of prurigo is unsatisfactory and challenging. Conventional systemic treatments may be beneficial; however, their possible side effects and possible transient efficacy is still a problem. We aimed to present the clinical course and effect of treatment with alitretinoin on patients with prurigo nodularis initially treated with conventional treatments like oral antihistamine, cyclosporine, and phototherapy. Methods: all the patients had prurigo nodularis refractory to conventional treatment. Their medical records included demographic features, past medical history, duration of disease, and treatment modalities; and the clinical courses of the patients were reviewed for this retrospective study. We evaluated patient pruritus and skin lesions for the duration. Results: we present reports involving 10 patients with refractory prurigo. All the patients in our cases were treated with oral alitretinoin after previous treatments and reported the improvement of skin lesions and pruritus within 2 weeks to 3 months. Conclusions: we suggest that oral alitretinoin may be an effective and well tolerated treatment option for patients with intractable prurigo. Further clinical studies are warranted to confirm the long-lasting efficacy and safety of alitretinoin for treating patients with prurigo.<\/jats:p>","DOI":"10.3390\/medicina56110599","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T10:47:28Z","timestamp":1605005248000},"page":"599","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oral Alitretinoin for Patients with Refractory Prurigo"],"prefix":"10.3390","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2795-0140","authenticated-orcid":false,"given":"Bo Young","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University college of Medicine, 1, Singil-ro, Yeoungdeungpo-gu, Seoul 07441, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Um","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University college of Medicine, 1, Singil-ro, Yeoungdeungpo-gu, Seoul 07441, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6532-2244","authenticated-orcid":false,"given":"Seok Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University college of Medicine, 1, Singil-ro, Yeoungdeungpo-gu, Seoul 07441, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1037-2209","authenticated-orcid":false,"given":"Min Je","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University college of Medicine, 1, Singil-ro, Yeoungdeungpo-gu, Seoul 07441, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-6951","authenticated-orcid":false,"given":"Jin Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University college of Medicine, 1, Singil-ro, Yeoungdeungpo-gu, Seoul 07441, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Suk","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Burn Center, Hangang Sacred Heart Hospital, Hallym University College of Medicine, 94-200 Yeoungdeungpo-dong, Yeoungdeungpo-gu, Seoul 07247, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4512-8668","authenticated-orcid":false,"given":"Chun Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University college of Medicine, 1, Singil-ro, Yeoungdeungpo-gu, Seoul 07441, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-0008","authenticated-orcid":false,"given":"Hye One","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University college of Medicine, 1, Singil-ro, Yeoungdeungpo-gu, Seoul 07441, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2165\/00128071-200405020-00003","article-title":"Prurigo: Diagnosis and management","volume":"5","author":"Wallengren","year":"2004","journal-title":"Am. 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