{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:14:54Z","timestamp":1792880094754,"version":"4.5.0"},"reference-count":76,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Cervical cancer results from a continuous process, starting from a normal cervical epithelium after human papillomavirus (HPV) infection and progressing to cervical intraepithelial neoplasia (CIN), before finally developing into invasive squamous carcinoma (ISC). In recent decades, dietary antioxidants, such as vitamins, have received much attention in relation to cancer prevention. We reviewed the relevant literature to investigate the dietary and nutrient intake on cervical cancer. The intake of vitamins A and D and carotenoids may inhibit early cervical cancer development. The intake of folate may prevent or inhibit HPV infection rom progressing to various grades of CIN. The intake of vitamins C and E may widely inhibit the process of cervical cancer development. Polyphenols are often used in cases of cervical cancer in combination chemotherapy and radiation therapy. Regarding nutrients, different antioxidants may have differing abilities to intervene in the natural history of cervical diseases associated with HPV infection. Regarding foods, the intake of both vegetables and fruits containing multiple vitamins may widely suppress cervical cancer development. Most previous papers have described epidemiological studies. Thus, further research using in vitro and in vivo approaches will be needed to clarify the effects of the dietary and nutrient intake in detail.<\/jats:p>","DOI":"10.3390\/medicina56110604","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T10:47:28Z","timestamp":1605005248000},"page":"604","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development"],"prefix":"10.3390","volume":"56","author":[{"given":"Ayumi","family":"Ono","sequence":"first","affiliation":[{"name":"Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-4430","authenticated-orcid":false,"given":"Masafumi","family":"Koshiyama","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Seki","sequence":"additional","affiliation":[{"name":"Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Oowaki","sequence":"additional","affiliation":[{"name":"Graduate School of Human Nursing, The University of Shiga Prefecture, Shiga 522-8533, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21387","article-title":"Cancer Statics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/annonc\/mdt538","article-title":"Cervical cancer screening: On the way to a shift from cytology to full molecular screening","volume":"25","author":"Dijkstra","year":"2014","journal-title":"Ann. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.3892\/ol.2016.4903","article-title":"HPV strain distribution in patients with genital warts in a female population sanple","volume":"12","author":"Boda","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2019.03116","article-title":"Human papillomavirus E6 and E7: The cervical cancer hallmarks and targets for therapy","volume":"10","author":"Pal","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/carcin\/bgv126","article-title":"HPV 16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells","volume":"36","author":"Marullo","year":"2014","journal-title":"Carcinogenesis"},{"key":"ref_6","first-page":"637","article-title":"Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues","volume":"52","author":"Boda","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/MMBR.68.2.362-372.2004","article-title":"Pathogenesis of human papillomaviruses in differentiating epithelia","volume":"68","author":"Longworth","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s13277-013-0804-1","article-title":"Defective antioxidant systems in cervical cancer","volume":"34","author":"Jiang","year":"2013","journal-title":"Tumour. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1038\/sj.onc.1207716","article-title":"Diet and cancer prevention","volume":"23","author":"McCullough","year":"2004","journal-title":"Oncogene"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S1470-2045(11)70282-0","article-title":"Antioxidants and cancer","volume":"12","author":"Stebbing","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_11","first-page":"1","article-title":"Associations between, antioxidant vitamins and the risk of invasive cervical cancer Chinese women: A case-control study","volume":"5","author":"Guo","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_12","unstructured":"NIH, National Institutes of Health (2020, June 01). Health Information. Vitamin A, Available online: https:\/\/ods.od.nih.gov\/factsheets\/VitaminA-HealthProfessional\/."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4103\/0019-509X.55549","article-title":"Lipid peroxidation and antioxidants in different stages of cervical cancer: Prognostic significance","volume":"46","author":"Srivasta","year":"2009","journal-title":"Indian J. Cancer"},{"key":"ref_14","first-page":"4317610","article-title":"Association between dietary vitamin A and HPV infection in American women: Data from NHANES 2003\u20132016","volume":"2020","author":"Huang","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1189\/jlb.71.1.16","article-title":"Nutrients and their role in host resistance to infection","volume":"71","author":"Field","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1207\/S15327914NC382_1","article-title":"Serum micronutrients and cervical dysplasia in Southwestern American Indian women","volume":"38","author":"Yeo","year":"2000","journal-title":"Nutr. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.7314\/APJCP.2015.16.7.2981","article-title":"Serum carotenoid, retinol and tocopherol concentrations and risk of cervical cancer among Chinese women","volume":"16","author":"Zhang","year":"2015","journal-title":"Asian Pac. Cancer Prev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Koshiyama, M. (2019). The effects of the dietary and nutrient intake on gynecologic cancers. Healthcare, 7.","DOI":"10.3390\/healthcare7030088"},{"key":"ref_19","first-page":"1","article-title":"Effectiveness and safety of vitamin D in relation to bone health","volume":"158","author":"Cranney","year":"2007","journal-title":"Evid. Rep. Technol. Assess."},{"key":"ref_20","unstructured":"NIH, National Institutes of Health (2020, July 09). Health Information. Vitamin D, Available online: https:\/\/ods.od.nih.gov\/factsheets\/VitaminDHealthProfessional\/."},{"key":"ref_21","unstructured":"Bowman, B.A., and Russell, R.M. (2006). Vitamin D. Present Knowledge in Nutrition, ILSI Press. [9th ed.]."},{"key":"ref_22","first-page":"e22604","article-title":"Effect of vitamin D supplementation on glucose control and inflammatory response in type II diabetes: A double blind, randomized clinical trial","volume":"13","author":"Jammah","year":"2015","journal-title":"Int. J. Endocrinol. Metab."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1017\/S0007114509992017","article-title":"Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient\u2014A randomized, placebo\u2014Controlled trial","volume":"103","author":"Stonehouse","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000487270","article-title":"Long-term vitamin D supplementation and the effects on recurrence and metabolic status of cervical intraepithelial neoplasia grade 2 or 3: A randomized, double-blind, placebo-controlled trial","volume":"72","author":"Vahedpoor","year":"2018","journal-title":"Ann. Nutr. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/ejcn.2010.28","article-title":"Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women","volume":"64","author":"Hosono","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12672-016-0278-x","article-title":"Effects of long-term vitamin D supplementation on regression and metabolic status of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial","volume":"8","author":"Vahedpoor","year":"2017","journal-title":"Hormones Cancer"},{"key":"ref_27","first-page":"e27791","article-title":"Chronical cervical infections and dysplasia (CIN I, CIN II): Vaginal vitamin D (high dose) treatment: A new effective method?","volume":"6","author":"Schlett","year":"2014","journal-title":"Dermatoendocrinol"},{"key":"ref_28","first-page":"177","article-title":"Could 25-oh vitamin D deficiency be a reason for HPV infection persistence in cervical premakignant lesions?","volume":"11","author":"Erkaya","year":"2016","journal-title":"J. Exp. Ther. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Deuster, E., Jeschke, U., Ye, Y., Mahner, S., and Czogalla, B. (2017). Vitamin D and VDR in gynecological cancers\u2014A systematic review. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112328"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1086\/379197","article-title":"Dietary intake and risk of persistent human papillomavirus (HPV) infection: The Ludwig-McGill HPV Natural History Study","volume":"188","author":"Giuliano","year":"2003","journal-title":"J. Infect. Dis."},{"key":"ref_31","first-page":"876","article-title":"Vitamin A, carotenoids, and risk of persistent oncogenic human papillomavirus infection","volume":"11","author":"Sedjo","year":"2002","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1080\/01635581003693074","article-title":"Combined antioxidant carotenoids and the risk of persistent human papillomavirus infection","volume":"62","author":"Peterson","year":"2010","journal-title":"Nutr. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1023\/A:1023981505268","article-title":"Effect of plasma micronutrients on clearance of oncogenic human papillomavirus (HPV) infection (United States)","volume":"14","author":"Sedjo","year":"2003","journal-title":"Cancer Causes Control"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1158\/0008-5472.CAN-07-0313","article-title":"Hawaii cohort study of serum micronutrient concentrations and clearance of incident oncogenic human papillomavirus infection of the cervix","volume":"67","author":"Goodman","year":"2007","journal-title":"Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ijc.24793","article-title":"Diet and serum micronutritions in relation to cervical neoplasia and cancer among low-income Brazilian women","volume":"126","author":"Tomita","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1017\/S0007114510004447","article-title":"Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: Modification by smoking","volume":"105","author":"Tomita","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/01635581.2013.757630","article-title":"A review of dietary prevention of human papillomavirus-related infection of the cervix and cervical intraepithelial neoplasia","volume":"65","author":"Chih","year":"2013","journal-title":"Nutr. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1158\/0008-5472.CAN-04-2402","article-title":"Folate is associated with the natural history of high-risk human papillomaviruses","volume":"64","author":"Piyathilake","year":"2004","journal-title":"Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1023\/B:CACO.0000003841.54413.98","article-title":"Diet and premalignant lesions of the cervix: Evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12","volume":"14","author":"Hernandez","year":"2003","journal-title":"Cancer Causes Control"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.nutres.2005.05.004","article-title":"Low folate status as a risk factor for cervical dysplasia in Thai women","volume":"25","author":"Kwanbunjan","year":"2005","journal-title":"Nutr. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.3945\/jn.113.182212","article-title":"Polymorphisms in gene involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia","volume":"143","author":"Tomita","year":"2013","journal-title":"J. Nutr."},{"key":"ref_42","unstructured":"NIH, National Institutes of Health (2020, July 14). Health Information. Vitamin C. Available online: https:\/\/www.nhs.uk\/conditions\/+vitamins-and-minerals\/vitamin-c\/."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/01635581.2016.1115101","article-title":"Association between vitamin C intake and the risk of cervical neoplasia: A meta-analysis","volume":"68","author":"Cao","year":"2016","journal-title":"Nutr. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0009-9120(02)00376-4","article-title":"Circulating lipid peroxidation and antioxidant status in cervical cancer patients: A case-control study","volume":"35","author":"Manju","year":"2002","journal-title":"Clin. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1007\/s00432-016-2235-z","article-title":"Vitamin C in synergism with cisplatin induces cell death in cervical cancer cells through altered redox cycling and p53 upregulation","volume":"142","author":"Leekha","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_46","unstructured":"NIH, National Institutes of Health (2020, July 16). Health Information. Vitamin E, Available online: https:\/\/ods.od.nih.gov\/factsheets\/VitaminE-HealthProfessional\/."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3109\/1061186X.2015.1135335","article-title":"Vitamin E derivative-based multifunctional nanoemulsions for overcoming multidrug resistance in cancer","volume":"24","author":"Xheng","year":"2016","journal-title":"J. Drug Target"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/ijc.22346","article-title":"Associations between serum carotenoids and tocopherols and type-specific HPV persistence: The Ludwig-McGill cohort study","volume":"120","author":"Siegel","year":"2007","journal-title":"Int. J. Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"96S","DOI":"10.1080\/07315724.2001.10719172","article-title":"Antioxidants and viral infections: Host immune response and viral pathogenicity","volume":"20","author":"Beck","year":"2001","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00008469-200308000-00013","article-title":"Plasma concentrations of coenzyme Q10 and tocopherols on cervical intraepithelial neoplasia and cervical cancer","volume":"12","author":"Palan","year":"2003","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"215S","DOI":"10.1093\/ajcn\/81.1.215S","article-title":"Polyphenols: Antioxidants and beyond","volume":"81","author":"Scalbert","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/01.mog.0000208463.69266.8c","article-title":"Polyphenols and gastrointestinal diseases","volume":"22","author":"Dryden","year":"2006","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Moga, M.A., Dimienescu, O.G., Arvatescu, C.A., Mironescu, A., Dracea, L., and Ples, L. (2016). The role of natural polyphenols in the prevention and treatment of cervical cancer-an overview. Molecules, 21.","DOI":"10.3390\/molecules21081055"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3892\/or.2012.1841","article-title":"Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species","volume":"28","author":"He","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.bcp.2005.01.022","article-title":"The effect of quercetin of pro-apoptotic activity of cisplatin in HeLa cells","volume":"69","author":"Paduch","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Xu, Y., Xin, Y., Diano, Y., Lu, C., Fu, J., Luo, L., and Yin, Z. (2011). Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0029169"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1039\/C6FO00551A","article-title":"Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchiymal transition signaling","volume":"8","author":"Lin","year":"2017","journal-title":"Food Funct."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2016.01.012","article-title":"Synergistic anticancer activity of dietary tea polyphenols and bleomycin hydrochloride in human cervical cancer cell: Caspase-dependent and independent apoptotic pathways","volume":"247","author":"Alshatwi","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.radonc.2011.10.023","article-title":"Combination of quercetin with radiotherapy enhances tumor radiosensitivity in vitro and in vivo","volume":"104","author":"Lin","year":"2012","journal-title":"Radiother. Oncol."},{"key":"ref_60","first-page":"523","article-title":"Sensitization of the apoptotic effect of gamma-irradiation in genistein-oretreated CaSki cervical cancer cells","volume":"18","author":"Shin","year":"2008","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_61","unstructured":"Ali, A., Devarajan, S., Waly, M.I., Essa, M.M., and Rahman, M.S. (2011). Nutritional and medical values of papaya (carica papaya L.). Natural Products and Their Active Compounds on Disease Prevention, Nova Science Publishers, Inc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ygyno.2010.05.022","article-title":"Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia","volume":"118","author":"Siegel","year":"2010","journal-title":"Gynecol. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.nut.2013.08.019","article-title":"Effect of fruit and vegetable antioxidants on total antioxidant capacity of blood plasma","volume":"30","author":"Harasym","year":"2014","journal-title":"Nutrition"},{"key":"ref_64","first-page":"973","article-title":"The association between dietary intake and cervical intraepithelial neoplasia grade 2 or higher among women in a high-risk rural area of China","volume":"287","author":"Feng","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10552-009-9433-9","article-title":"The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia","volume":"21","author":"Hwang","year":"2010","journal-title":"Cancer Causes Control"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.7314\/APJCP.2012.13.10.5299","article-title":"Case-control study of diet in patients with cervical cancer or precancerosis in Wufeng, a high incidence region in China","volume":"13","author":"Jia","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Barchitta, M., Maugeri, A., Quattrocchi, A., Agrifoglio, O., Scalisi, A., and Agodi, A. (2018). The association of dietary patterns with high-risk human papillomavirus infection and cervical cancer: A cross-sectional study in Italy. Nutrients, 10.","DOI":"10.20944\/preprints201803.0109.v1"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ijc.25679","article-title":"Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study","volume":"129","author":"Travier","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF03345705","article-title":"Effect of high-dose isoflavones on cognition, quality of life, androgens, and lipoprotein in post-menopausal women","volume":"32","author":"Basaria","year":"2009","journal-title":"J. Endocrinol. Investig."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"32","DOI":"10.5114\/pm.2018.73791","article-title":"Isoflavones, calcium, vitamin D and insulin improve quality of life, sexual function, body composition and metabolic parameters in menopausal women: Result from a prospective, randomized, placebo-controlled, parallel-group study","volume":"17","author":"Vitale","year":"2018","journal-title":"Menopause Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"19","DOI":"10.17140\/WHOJ-5-133","article-title":"Relationship between tobacco smoking and cervical cancer","volume":"5","author":"Ono","year":"2019","journal-title":"Women\u2019s Health Open J."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Koshiyama, M., Nakagawa, M., and Ono, A. (2019). The preventive effects of dietary antioxidants against cervical cancer versus the promotive effect of tobacco smoking. Healthcare, 7.","DOI":"10.3390\/healthcare7040162"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrc1190","article-title":"Tobacco carcinogens, their biomarkers and tobacco-induced cancer","volume":"3","author":"Hecht","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1093\/carcin\/bgu156","article-title":"Tobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes","volume":"35","author":"Wei","year":"2014","journal-title":"Carcinogenesis"},{"key":"ref_75","first-page":"685","article-title":"P16INK4a as a progression\/regression tumour marker in LSIL cervix lesions: Our clinical experience","volume":"37","author":"Vitale","year":"2016","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.anndiagpath.2018.12.001","article-title":"The distribution of novel biomarkers in carcinoma-in-situ, microinvasive, and squamous cell carcinoma of the uterine cervix","volume":"38","author":"Nicol","year":"2019","journal-title":"Ann. Diagn. Pathol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/11\/604\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:31:33Z","timestamp":1760178693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/11\/604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":76,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["medicina56110604"],"URL":"https:\/\/doi.org\/10.3390\/medicina56110604","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,10]]}}}