{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:25:45Z","timestamp":1772252745616,"version":"3.50.1"},"reference-count":39,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Chondroitin sulfate ABC endolyase (condoliase) was launched as a new drug for chemonucleolysis in 2018. Few studies assessed its clinical outcomes, and many important factors remain unclear. This study aimed to clarify the preoperative conditions in which condoliase could be highly effective. Materials and Methods: Of 47 patients who received condoliase, 34 were enrolled in this study. The mean age of the patients was 33 years. The average duration since the onset of disease was 8.6 months. We evaluated patients\u2019 low back and leg pain using a numerical rating scale (NRS) score at two time points (before therapy and 3 months after therapy). We divided the patients into two groups (good group (G): NRS score improvement \u2265 50%, poor group (P): NRS score improvement &lt; 50%). The parameters evaluated were age, disease duration, body mass index (BMI), and positive or negative straight leg raising test results. In addition, the loss of disc height and preoperative radiological findings were evaluated. Results: In terms of low back and leg pain, the G group included 9\/34 (26.5%) and 21\/34 (61.8%) patients, respectively. Patients\u2019 age (low back pain G\/P, 21\/36.5 years) was significantly lower in the G group for low back pain (p = 0.001). High-intensity change in the protruded nucleus pulposus (NP) and spinal canal occupancy by the NP \u2265 40% were significantly high in those with leg pain in the G groups (14\/21, p = 0.04; and 13\/21, p = 0.03, respectively). Conclusions: The efficacy of improvement in leg pain was significantly correlated with high-intensity change and size of the protruded NP. Condoliase was not significantly effective for low back pain but could have an effect on younger patients.<\/jats:p>","DOI":"10.3390\/medicina56110627","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T10:46:26Z","timestamp":1605782786000},"page":"627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Chemonucleolysis with Chondroitin Sulfate ABC Endolyase for Treating Lumbar Disc Herniation: Exploration of Prognostic Factors for Good or Poor Clinical Outcomes"],"prefix":"10.3390","volume":"56","author":[{"given":"Katsuhiko","family":"Ishibashi","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Iwai FESS Clinic, 8-18-4 Minamikoiwa Edogawa-ku, Tokyo 133-0056, Japan"},{"name":"Department of Orthopaedics, Iwai Orthopaedic Medical Hospital, 8-17-2 Minamikoiwa Edogawa-ku, Tokyo 133-0056, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneyoshi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Iwai FESS Clinic, 8-18-4 Minamikoiwa Edogawa-ku, Tokyo 133-0056, Japan"},{"name":"Department of Orthopaedic Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8606, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Iwai Orthopaedic Medical Hospital, 8-17-2 Minamikoiwa Edogawa-ku, Tokyo 133-0056, Japan"},{"name":"Department of Orthopaedic Surgery, Inanami Spine and Joint Hospital, 3-17-5 Higashishinagawa Shinagawa-ku, Tokyo 140-0002, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Iwai FESS Clinic, 8-18-4 Minamikoiwa Edogawa-ku, Tokyo 133-0056, Japan"},{"name":"Department of Orthopaedics, Iwai Orthopaedic Medical Hospital, 8-17-2 Minamikoiwa Edogawa-ku, Tokyo 133-0056, Japan"},{"name":"Department of Orthopaedic Surgery, Inanami Spine and Joint Hospital, 3-17-5 Higashishinagawa Shinagawa-ku, Tokyo 140-0002, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohiko","family":"Inanami","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Iwai FESS Clinic, 8-18-4 Minamikoiwa Edogawa-ku, Tokyo 133-0056, Japan"},{"name":"Department of Orthopaedics, Iwai Orthopaedic Medical Hospital, 8-17-2 Minamikoiwa Edogawa-ku, Tokyo 133-0056, Japan"},{"name":"Department of Orthopaedic Surgery, Inanami Spine and Joint Hospital, 3-17-5 Higashishinagawa Shinagawa-ku, Tokyo 140-0002, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Iwai FESS Clinic, 8-18-4 Minamikoiwa Edogawa-ku, Tokyo 133-0056, Japan"},{"name":"Department of Orthopaedics, Iwai Orthopaedic Medical Hospital, 8-17-2 Minamikoiwa Edogawa-ku, Tokyo 133-0056, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/jama.1964.03060150061016","article-title":"Enzyme dissolution of the nucleus pulposus in humans","volume":"187","author":"Smith","year":"1964","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/00007632-198802000-00010","article-title":"Quantitative assessment of human proteinases as agents for chemonucleolysis","volume":"13","author":"Dando","year":"1988","journal-title":"Spine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/00007632-198707000-00009","article-title":"Experimental model of disc herniations in rats for study of 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