{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:56Z","timestamp":1783468856262,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Arterial hypertension remains an important cause of cardiovascular morbidity and mortality, despite all the progress made in the methods of diagnosis, monitoring of target organs\u2019 damage and treatment. The main cause of the increased prevalence of uncontrolled blood pressure values is the low compliance to antihypertensive treatment. The objective of our study was to assess the compliance to the treatment of patients diagnosed with arterial hypertension and monitored in a primary care office. Materials and Methods: The cross-sectional, retrospective study included 129 patients, 65.89% (85) women, previously diagnosed with arterial hypertension. Data from the medical files were analyzed, as well as the patients\u2019 answers to a survey of 18 questions regarding arterial hypertension, comorbidities, complications, treatment and awareness of the condition. Results: The study included 129 patients, with a mean age of 66 \u00b1 8 years. The majority of patients were overweight, 55.81% (72 patients), and 10.85% (14 patients) had grade I obesity. Most of the patients, 55.81% (72 patients) were diagnosed with grade III hypertension, while 37.98% (49 patients) were diagnosed with grade II hypertension and 6.2% (8 patients) with grade I hypertension. One third of the surveyed patients answered that they follow the recommendations of a low-sodium diet, 21.7% are adherent to treatment, but 56% think that the total cost of the medication is an impediment for their compliance to treatment. The majority, 82.17% (106 patients), of respondents had an affirmative answer to the questions: \u2018Do you think it would be easier to take one pill instead of 2, 3 or 4 pills?\u2019 Conclusion: The increased compliance to the antihypertensive treatment and control of blood pressure values are associated with the degree of awareness of arterial hypertension and the consequences if left untreated, emphasizing the role of the general practitioner in counseling for secondary prevention.<\/jats:p>","DOI":"10.3390\/medicina56110631","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T01:28:48Z","timestamp":1606094928000},"page":"631","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Therapeutic Compliance of Patients with Arterial Hypertension in Primary Care"],"prefix":"10.3390","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2881-878X","authenticated-orcid":false,"given":"Mihaela Adela","family":"Iancu","sequence":"first","affiliation":[{"name":"Department 5, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Primary Care Office, 011165 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina-Ioana","family":"Mateiciuc","sequence":"additional","affiliation":[{"name":"Department 5, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-9470","authenticated-orcid":false,"given":"Ana-Maria Alexandra","family":"Stanescu","sequence":"additional","affiliation":[{"name":"Department 5, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dumitru","family":"Matei","sequence":"additional","affiliation":[{"name":"Department 5, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Alessandrescu-Rusescu National Institute for Mother and Child Health, 020395 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6837-260X","authenticated-orcid":false,"given":"Camelia Cristina","family":"Diaconu","sequence":"additional","affiliation":[{"name":"Department 5, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Internal Medicine, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: Analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1001\/jama.289.18.2363","article-title":"Hypertension Prevalence and Blood Pressure Levels in 6 European Countries, Canada, and the United States","volume":"289","author":"Cooper","year":"2003","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","article-title":"Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study","volume":"364","author":"Yusufali","year":"2004","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/HJH.0000000000001572","article-title":"Perspectives on hypertension\u2019s prevalence, treatment and control in a high cardiovascular risk East European country","volume":"36","author":"Dorobantu","year":"2018","journal-title":"J. Hypertens."},{"key":"ref_6","first-page":"303","article-title":"The Prevalence of Arterial Hypertension in Romanian Adult Population: Results from the Predatorr Study","volume":"25","year":"2018","journal-title":"Rom. J. Diabetes Nutr. Metab. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40119-019-00159-1","article-title":"Facing the Challenge of Lowering Blood Pressure and Cholesterol in the Same Patient: Report of a Symposium at the European Society of Hypertension","volume":"9","author":"Williams","year":"2020","journal-title":"Cardiol. Ther."},{"key":"ref_8","first-page":"564","article-title":"Predictors of Poor Adherence to Hypertension Treatment","volume":"97","author":"Omezzine","year":"2019","journal-title":"Tunis. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Gavrilova, A., Bandere, D., Rutkovska, I., Smits, D., Maurina, B., Poplavska, E., and Urt\u0101ne, I. (2019). Knowledge about Disease, Medication Therapy, and Related Medication Adherence Levels among Patients with Hypertension. Medicina, 55.","DOI":"10.3390\/medicina55110715"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.maturitas.2018.03.013","article-title":"Hypertension in patients with type 2 diabetes mellitus: Targets and management","volume":"112","author":"Pavlou","year":"2018","journal-title":"Maturitas"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/01.mlr.0000166617.68751.5f","article-title":"The Importance of Medication Adherence in Improving Chronic-Disease Related Outcomes","volume":"43","author":"Balkrishnan","year":"2005","journal-title":"Med. Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/HYPERTENSIONAHA.109.132688","article-title":"Triple fixed-dose combination therapy: Back to the past","volume":"54","author":"Black","year":"2009","journal-title":"Hypertension"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e011650","DOI":"10.1136\/bmjopen-2016-011650","article-title":"Comparison of therapy persistence for fixed versus free combination antihypertensives: A retrospective cohort study","volume":"6","author":"Grimmsmann","year":"2016","journal-title":"BMJ Open"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/CIRCRESAHA.118.313220","article-title":"Adherence in Hypertension","volume":"124","author":"Burnier","year":"2019","journal-title":"Circ. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/JCN.0000000000000089","article-title":"Adherence to a Low-Sodium Diet in Patients With Heart Failure Is Best When Family Members Also Follow the Diet","volume":"30","author":"Chung","year":"2015","journal-title":"J. Cardiovasc. Nurs."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s11739-019-02269-z","article-title":"Hypertension prevalence, awareness, treatment, and control in Surinamese living in Suriname and The Netherlands: The HELISUR and HELIUS studies","volume":"15","author":"Diemer","year":"2020","journal-title":"Intern. Emerg. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00038-019-01317-x","article-title":"Interventions to increase the pharmacological adherence on arterial hypertension in Latin America: A systematic review","volume":"65","year":"2020","journal-title":"Int. J. Public Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2147\/PPA.S216091","article-title":"Medication Adherence in Patients with Arterial Hypertension: The Relationship With Healthcare Systems\u2019 Organizational Factors","volume":"13","author":"Carvalho","year":"2019","journal-title":"Patient Prefer. Adherence"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Garz\u00f3n, N.E., and Heredia, L.P.D. (2019). Validity and Reliability of the Treatment Adherence Questionnaire for Patients with Hypertension. Invest. Educ. Enferm., 37.","DOI":"10.17533\/udea.iee.v37n3e09"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13690-019-0366-9","article-title":"Adherence to antihypertensive medication in Russia: A scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017","volume":"77","author":"Bochkareva","year":"2019","journal-title":"Arch. Public Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/HYPERTENSIONAHA.119.13437","article-title":"Future of Hypertension","volume":"74","author":"Dzau","year":"2019","journal-title":"Hypertension"},{"key":"ref_22","first-page":"10","article-title":"Arterial hypertension epidemiology: Romania among the balkan countries\u2013data from SEPHAR Surveys","volume":"21","author":"Dorobantu","year":"2014","journal-title":"Mod. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/00015385.2017.1421445","article-title":"Drug-induced arterial hypertension\u2013a frequently ignored cause of secondary hypertension: A review","volume":"73","author":"Diaconu","year":"2018","journal-title":"Acta Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2147\/TCRM.S1458","article-title":"Factors affecting therapeutic compliance: A review from the patient\u2019s perspective","volume":"4","author":"Li","year":"2008","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11892-019-1239-x","article-title":"Diabetes and Cardiovascular Disease: An Update","volume":"19","author":"Almourani","year":"2019","journal-title":"Curr. Diabetes Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Parra, D.I., Guevara, S.L.R., and S\u00e1nchez, L.Z.R. (2019). Influential Factors in Adherence to the Therapeutic Regime in Hypertension and Diabetes. Invest. Educ. Enferm., 37.","DOI":"10.17533\/udea.iee.v37n3e02"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.31688\/ABMU.2019.54.3.15","article-title":"Improving the drug compliance of hypertensive patients in primary care: Importance of health education and self-management","volume":"54","author":"Korzh","year":"2019","journal-title":"Arch. Balk. Med. Union"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/5584_2016_77","article-title":"Adherence to Treatment in Hypertension","volume":"956","author":"Villalva","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_29","first-page":"e201910080","article-title":"Evaluation of satisfaction with pharmacological treatment in people with hypertension","volume":"93","author":"Hidalgo","year":"2019","journal-title":"Rev. Esp. Salud Publica"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/11\/631\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:35:46Z","timestamp":1760178946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/11\/631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,22]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["medicina56110631"],"URL":"https:\/\/doi.org\/10.3390\/medicina56110631","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,22]]}}}