{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:17:35Z","timestamp":1777425455084,"version":"3.51.4"},"reference-count":27,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the European Social Fund under the Global Grant measure","award":["VP1-3.1-SMM-07-K-03-080"],"award-info":[{"award-number":["VP1-3.1-SMM-07-K-03-080"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objective: Glaucoma is a progressive optic neuropathy in which the optic nerve is damaged. The optic nerve is exposed not only to intraocular pressure (IOP) in the eye, but also to intracranial pressure (ICP), as it is surrounded by cerebrospinal fluid in the subarachnoid space. Here, we analyse ICP differences between patients with glaucoma and healthy subjects (HSs). Materials and Methods: Ninety-five patients with normal-tension glaucoma (NTG), 60 patients with high-tension glaucoma (HTG), and 62 HSs were included in the prospective clinical study, and ICP was measured non-invasively by two-depth transcranial Doppler (TCD). Results: The mean ICP of NTG patients (9.42 \u00b1 2.83 mmHg) was significantly lower than that of HSs (10.73 \u00b1 2.16 mmHg) (p = 0.007). The mean ICP of HTG patients (8.11 \u00b1 2.68 mmHg) was significantly lower than that of NTG patients (9.42 \u00b1 2.83 mmHg) (p = 0.008) and significantly lower than that of HSs (10.73 \u00b1 2.16 mmHg) (p &lt; 0.001). Conclusions: An abnormal ICP value could be one of the many influential factors in the optic nerve degeneration of NTG patients and should be considered as such instead of just being regarded as a \u201clow ICP\u201d.<\/jats:p>","DOI":"10.3390\/medicina56120664","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T10:26:12Z","timestamp":1606731972000},"page":"664","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects"],"prefix":"10.3390","volume":"56","author":[{"given":"Mantas","family":"Deimantavicius","sequence":"first","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-5068","authenticated-orcid":false,"given":"Yasin","family":"Hamarat","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulius","family":"Lucinskas","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolandas","family":"Zakelis","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laimonas","family":"Bartusis","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Siaudvytyte","sequence":"additional","affiliation":[{"name":"Eye Clinic, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2660-7922","authenticated-orcid":false,"given":"Ingrida","family":"Janulevicien\u0117","sequence":"additional","affiliation":[{"name":"Eye Clinic, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arminas","family":"Ragauskas","sequence":"additional","affiliation":[{"name":"Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s40135-015-0067-7","article-title":"Lamina Cribrosa in Glaucoma: Diagnosis and Monitoring","volume":"3","author":"Abe","year":"2015","journal-title":"Curr. 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