{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:29:23Z","timestamp":1760239763478,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The simplified interpretation of serum ferritin levels, according to which low ferritin levels indicate iron deficiency and high levels indicate hemochromatosis is obsolete, as in the presence of inflammation serum ferritin levels, no longer correlate with iron stores. However, further data are needed to interpret serum ferritin levels correctly in patients with ongoing inflammation. Our study aimed to assess serum iron and ferritin dynamics in patients with long intensive care unit (ICU) stay and the possible correlations with organ dysfunction progression and outcome. Materials and Methods: We conducted a prospective study in a university hospital ICU over six months. All patients with an ICU length-of-stay of more than seven days were enrolled. Collected data included: demographics, Sequential Organ Failure Assessment (SOFA) score, admission, weekly serum iron and ferritin levels, ICU length-of-stay and outcome. Interactions between organ dysfunction progression and serum iron and ferritin levels changes were investigated. Outcome predictive value of serum ferritin was assessed. Results: Seventy-two patients with a mean ICU length-of-stay of 15 (4.4) days were enrolled in the study. The average age of patients was 62 (16.8) years. There were no significant differences between survivors (39 patients, 54%) and nonsurvivors (33 patients, 46%) regarding demographics, serum iron and ferritin levels and SOFA score on ICU admission. Over time, serum iron levels remained normal or low, while serum ferritin levels statedly increased in all patients. Serum ferritin increase was higher in nonsurvivors than survivors. There was a significant positive correlation between SOFA score and serum ferritin (r = 0.7, 95% CI for r = 0.64 to 0.76, p &lt; 0.01). The predictive outcome accuracy of serum ferritin was similar to the SOFA score. Conclusions: In patients with prolonged ICU stay, serum ferritin dynamics reflects organ dysfunction progression and parallels SOFA score in terms of outcome predictive accuracy.<\/jats:p>","DOI":"10.3390\/medicina57010001","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T20:39:29Z","timestamp":1608669569000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Outcome Predictive Value of Serum Ferritin in ICU Patients with Long ICU Stay"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-3493","authenticated-orcid":false,"given":"Daniel","family":"Rusu","sequence":"first","affiliation":[{"name":"Anaesthesia\u2014Intensive Care Unit Department, Grigore T Popa University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Anaesthesia and Intensive Care Department, Regional Institute of Oncology, 700483 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Blaj","sequence":"additional","affiliation":[{"name":"Anaesthesia\u2014Intensive Care Unit Department, Grigore T Popa University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Anaesthesia and Intensive Care Department, \u201cSf. Spiridon\u201d University Hospital, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-8068","authenticated-orcid":false,"given":"Irina","family":"Ristescu","sequence":"additional","affiliation":[{"name":"Anaesthesia\u2014Intensive Care Unit Department, Grigore T Popa University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Anaesthesia and Intensive Care Department, Regional Institute of Oncology, 700483 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Patrascanu","sequence":"additional","affiliation":[{"name":"Anaesthesia\u2014Intensive Care Unit Department, Grigore T Popa University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Anaesthesia and Intensive Care Department, Regional Institute of Oncology, 700483 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-8356","authenticated-orcid":false,"given":"Laura","family":"Gavril","sequence":"additional","affiliation":[{"name":"Anaesthesia\u2014Intensive Care Unit Department, Grigore T Popa University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Anaesthesia and Intensive Care Department, Regional Institute of Oncology, 700483 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olgu\u021ba","family":"Lungu","sequence":"additional","affiliation":[{"name":"Anaesthesia\u2014Intensive Care Unit Department, Grigore T Popa University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Anaesthesia and Intensive Care Department, Regional Institute of Oncology, 700483 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2072-1174","authenticated-orcid":false,"given":"Ianis","family":"Siriopol","sequence":"additional","affiliation":[{"name":"Anaesthesia\u2014Intensive Care Unit Department, Grigore T Popa University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Anaesthesia and Intensive Care Department, Regional Institute of Oncology, 700483 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6724-2029","authenticated-orcid":false,"given":"Iulian","family":"Buzincu","sequence":"additional","affiliation":[{"name":"Anaesthesia\u2014Intensive Care Unit Department, Grigore T Popa University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Anaesthesia and Intensive Care Department, Regional Institute of Oncology, 700483 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9412-9574","authenticated-orcid":false,"given":"Ioana","family":"Grigora\u0219","sequence":"additional","affiliation":[{"name":"Anaesthesia\u2014Intensive Care Unit Department, Grigore T Popa University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Anaesthesia and Intensive Care Department, Regional Institute of Oncology, 700483 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1164\/rccm.201002-0210CI","article-title":"Chronic critical illness","volume":"182","author":"Nelson","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.4187\/respcare.01768","article-title":"Chronic critical illness: The growing challenge to health care","volume":"57","author":"MacIntyre","year":"2012","journal-title":"Respir. Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0749-0704(02)00015-5","article-title":"The epidemiology and costs of chronic critical illness","volume":"18","author":"Carson","year":"2002","journal-title":"Crit. Care Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/CCM.0000000000001480","article-title":"Relationship between ICU Length of Stay and Long-Term Mortality for Elderly ICU Survivors","volume":"44","author":"Moitra","year":"2016","journal-title":"Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"859","DOI":"10.4187\/respcare.01719","article-title":"Persistent systemic inflammation in chronic critical illness","volume":"57","author":"Cox","year":"2012","journal-title":"Respir. Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000362888","article-title":"Physiology of iron metabolism","volume":"41","author":"Waeber","year":"2014","journal-title":"Transfus. Med. Hemother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1515\/cclm-2012-0129","article-title":"Revaluating serum ferritin as a marker of body iron stores in the traceability era","volume":"50","author":"Ferraro","year":"2012","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9394060","article-title":"Limitations of Serum Ferritin in Diagnosing Iron Deficiency in Inflammatory Conditions","volume":"2018","author":"Dignass","year":"2018","journal-title":"Int. J. Chronic Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/cei.13069","article-title":"Eppur Si Muove: Ferritin is essential in modulating inflammation","volume":"191","author":"Sharif","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.arcmed.2018.12.005","article-title":"Are Current Serum and Plasma Ferritin Cut-offs for Iron Deficiency and Overload Accurate and Reflecting Iron Status? A Systematic Review","volume":"49","author":"Pasricha","year":"2018","journal-title":"Arch. Med. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1039\/C3MT00347G","article-title":"Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells","volume":"6","author":"Kell","year":"2014","journal-title":"Metallomics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1182\/blood.V99.10.3505","article-title":"Regulation of ferritin genes and protein","volume":"99","author":"Torti","year":"2002","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1186\/s13054-019-2663-7","article-title":"The SOFA score-development, utility and challenges of accurate assessment in clinical trials","volume":"23","author":"Lambden","year":"2019","journal-title":"Crit. Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1373\/clinchem.2017.276055","article-title":"Increased plasma ferritin concentration and low-grade inflammation\u2014A mendelian randomisation study","volume":"64","author":"Moen","year":"2018","journal-title":"Clin. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1164\/ajrccm.159.5.9809027","article-title":"Initial serum ferritin levels in patients with multiple trauma and the subsequent development of acute respiratory distress syndrome","volume":"159","author":"Sharkey","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1186\/cc2185","article-title":"Erythropoietin mimics the acute phase response in critical illness","volume":"7","author":"Elliot","year":"2003","journal-title":"Crit. Care."},{"key":"ref_17","first-page":"1829","article-title":"Ferritin levels in children with severe sepsis and septic shock","volume":"96","author":"Garcia","year":"2007","journal-title":"Int. J. Paediatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/PCC.0000000000001029","article-title":"A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis","volume":"18","author":"Carcillo","year":"2017","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_19","first-page":"429","article-title":"Ferritin as a Marker of Severity in COVID-19 Patients: A Fatal Correlation","volume":"8","author":"Dahan","year":"2020","journal-title":"Isr. Med. Assoc. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/cc6413","article-title":"Biochemical markers of the iron metabolism and their relationship with the inflammatory status in multiple trauma patients","volume":"12","author":"Pavlou","year":"2008","journal-title":"Crit. 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