{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T13:29:20Z","timestamp":1774099760379,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UEFISCDI, PNCDI III framework","award":["PN-III-P4-ID-PCE-2016-0120"],"award-info":[{"award-number":["PN-III-P4-ID-PCE-2016-0120"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Vitamin D is involved in insulin resistance through genomic and non-genomic mechanisms. Several observational and randomized studies have discrepant results; some of them showed an improved insulin resistance (IR), and others a neutral effect after vitamin D deficiency is corrected. Materials and Methods: We designed a retrospective observational study that included all women who presented for 33 months in an outpatient clinic in Bucharest, Romania. Results: We analyzed 353 patients with a mean age of 58.5 \u00b1 13.7 years, a mean body mass index (BMI) of 27.36 \u00b1 4.87 kg\/m\u22122, and a mean level of 25-hydroxyvitamin D (25OHD) of 39.53 \u00b1 15.73 ng\/mL. There were no differences in the calculated Homeostatic Model Assessment of Insulin Resistance variants 1 and 2 (HOMA-IR) and the Quantitative Insulin Sensitivity Check Index (QUICKI) between women with vitamin D deficit versus normal values. In multivariate analysis, there was no significant relation between 25OHD and the response variables considered by us. Conclusions: We observed a small positive correlation between a higher level of 25OHD and increased glycosylated hemolobin (HbA1c) or IR indices without clinical significance. Other modifiable or non-modifiable factors override 25OHD influence on IR in adult women with a normal serum level and may contribute to the remainder of the variability observed.<\/jats:p>","DOI":"10.3390\/medicina57010025","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T09:35:23Z","timestamp":1609320923000},"page":"25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["No Association between 25-Hydroxyvitamin D and Insulin Resistance or Thyroid Hormone Concentrations in a Romanian Observational Study"],"prefix":"10.3390","volume":"57","author":[{"given":"Roxana Adriana","family":"Stoica","sequence":"first","affiliation":[{"name":"Departament of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Carol Davila, 020475 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Guja","sequence":"additional","affiliation":[{"name":"Departament of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Carol Davila, 020475 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0555-526X","authenticated-orcid":false,"given":"Anca","family":"Pantea-Stoian","sequence":"additional","affiliation":[{"name":"Departament of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Carol Davila, 020475 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8244-2483","authenticated-orcid":false,"given":"Raluca Ioana \u0218tefan-van","family":"Staden","sequence":"additional","affiliation":[{"name":"Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 060021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Popa-Tudor","sequence":"additional","affiliation":[{"name":"Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 060021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona Diana","family":"\u0218tefan","sequence":"additional","affiliation":[{"name":"Departament of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Carol Davila, 020475 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ancuceanu","sequence":"additional","affiliation":[{"name":"Departament of Botanical Pharmaceutics, University of Medicine and Pharmacy Carol Davila, 020956 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Serafinceanu","sequence":"additional","affiliation":[{"name":"Departament of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Carol Davila, 020475 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Ionescu T\u00eergovi\u0219te","sequence":"additional","affiliation":[{"name":"Departament of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Carol Davila, 020475 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"ref_1","first-page":"263","article-title":"Thyroid disorders and diabetes mellitus","volume":"99","author":"Grassetto","year":"2008","journal-title":"Minerva Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kim, D. 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