{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:09:10Z","timestamp":1793830150101,"version":"4.6.1"},"reference-count":74,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The aim of the present systematic review and meta-analysis was to investigate the efficacy of leukocyte\u2013platelet-rich fibrin (L-PRF) in addition to coronally advanced flap (CAF) for the treatment of both single and multiple gingival recessions (GRs) compared to the CAF alone and to the adjunct of connective tissue graft (CTG). Root coverage outcomes using platelet concentrates have gained increased interest. In particular, it has been suggested that adding L-PRF to CAF may provide further benefits in the treatment of GRs. Materials and Methods: An electronic and manual literature search was conducted to identify randomized controlled trials (RTCs) investigating root coverage outcomes with CAF + L-PRF. The outcomes of interest included mean root coverage (mRC), recession reduction, keratinized tissue width (KTW) gain, gingival thickness (GT) gain, and patient-reported outcome measures (PROms) such as pain perception and discomfort. Results: A total of 275 patients and 611 surgical sites were analyzed. L-PRF in adjunct to single CAF seems to show statistically significant results regarding clinical attachment level (CAL) with a weighted means (WM) 0.43 95% CI (\u22120.04, 0.91), p &lt; 0.0001, GT (WM 0.17 95% CI (\u22120.02, 0.36), p &lt; 0.0001, and mRC (WM 13.95 95% CI (\u22121.99, 29.88) p &lt; 0.0001, compared to single CAF alone. Interesting results were obtained from the adjunct of PRF to multiple CAF with respect to multiple CAF alone with an increase in the mRC WM 0.07 95% CI (\u221230.22, 30.35), p = 0.0001, and PPD change WM 0.26 95% CI (\u22120.06, 0.58), p &lt; 00001. On the other hand, no statistically significant data were obtained when L-PRF was added to single or multiple CAF combined with CTG according to the included outcomes such as mRC (p = 0.03 overall). Conclusions: L-PRF is a valid alternative to CAF alone. L-PRF compared to CTG in single and multiple CAF showed statistically significant results regarding pain perception and discomfort PROms (p &lt; 0.0001). However, CTG remains the gold standard for treating gingival recession.<\/jats:p>","DOI":"10.3390\/medicina57020144","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T08:33:48Z","timestamp":1612514028000},"page":"144","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Platelet-Rich Fibrin in Single and Multiple Coronally Advanced Flap for Type 1 Recession: An Updated Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-155X","authenticated-orcid":false,"given":"Leonardo","family":"Mancini","sequence":"first","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1699-2975","authenticated-orcid":false,"given":"Francesco","family":"Tarallo","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3184-6899","authenticated-orcid":false,"given":"Vincenzo","family":"Quinzi","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-2760","authenticated-orcid":false,"given":"Adriano","family":"Fratini","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3566-0434","authenticated-orcid":false,"given":"Stefano","family":"Mummolo","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6461-7876","authenticated-orcid":false,"given":"Enrico","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/jcpe.12948","article-title":"Mucogingival conditions in the natural dentition: Narrative review, case definitions, and diagnostic considerations","volume":"45","author":"Cortellini","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1532-3382(12)70025-8","article-title":"Esthetic soft tissue management for teeth and implants","volume":"12","author":"Fu","year":"2012","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1902\/jop.2004.75.10.1377","article-title":"Gingival recession: Epidemiology and risk indicators in a representative urban Brazilian population","volume":"75","author":"Susin","year":"2004","journal-title":"J. Periodontol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/jcpe.12303","article-title":"Estimates and multivariable risk assessment of gingival recession in the population of adults from Porto Alegre, Brazil","volume":"41","author":"Rios","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/jcpe.13353","article-title":"Epidemiology of mid-buccal gingival recessions in NHANES according to the 2018 World Workshop Classification System","volume":"47","author":"Romandini","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1177\/0022034519867071","article-title":"The Effect of Time on Root Coverage Outcomes: A Network Meta-analysis","volume":"98","author":"Tavelli","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/jcpe.12182","article-title":"Efficacy of periodontal plastic surgery procedures in the treatment of localized facial gingival recessions. A systematic review","volume":"41","author":"Cairo","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/JPER.18-0066","article-title":"Efficacy of tunnel technique in the treatment of localized and multiple gingival recessions: A systematic review and meta-analysis","volume":"89","author":"Tavelli","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/JPER.18-0732","article-title":"The influence of tooth location on the outcomes of multiple adjacent gingival recessions treated with coronally advanced flap: A multicenter re-analysis study","volume":"90","author":"Zucchelli","year":"2019","journal-title":"J. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/JPER.19-0350","article-title":"Autogenous soft tissue grafting for periodontal and peri-implant plastic surgical reconstruction","volume":"91","author":"Zucchelli","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/JPER.18-0201","article-title":"Influence of tooth location on coronally advanced flap procedures for root coverage","volume":"89","author":"Zucchelli","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/jcpe.13187","article-title":"Long term assessment of root coverage stability using connective tissue graft with or without an epithelial collar for gingival recession treatment. A 12-year follow-up from a randomized clinical trial","volume":"46","author":"Barootchi","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00784-018-2455-5","article-title":"Pain perception following epithelialized gingival graft harvesting: A randomized clinical trial","volume":"23","author":"Tavelli","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"127.e134","DOI":"10.11607\/prd.3581","article-title":"Minimizing Patient Morbidity Following Palatal Gingival Harvesting: A Randomized Controlled Clinical Study","volume":"38","author":"Tavelli","year":"2018","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1007\/s00784-019-03192-5","article-title":"An exploratory clinical study evaluating safety and performance of a volume-stable collagen matrix with coronally advanced flap for single gingival recession treatment","volume":"24","author":"Stefanini","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/JPER.19-0351","article-title":"Extracellular matrix-based scaffolding technologies for periodontal and peri-implant soft tissue regeneration","volume":"91","author":"Tavelli","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/jcpe.13163","article-title":"Acellular dermal matrix and coronally advanced flap or tunnel technique in the treatment of multiple adjacent gingival recessions. A 12-year follow-up from a randomized clinical trial","volume":"46","author":"Tavelli","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/JPER.19-0715","article-title":"Gingival phenotype modification therapies on natural teeth: A network meta-analysis","volume":"91","author":"Barootchi","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/JPER.19-0352","article-title":"Biologics-based regenerative technologies for periodontal soft tissue engineering","volume":"91","author":"Tavelli","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tavelli, L., Ravida, A., Barootchi, S., Chambrone, L., and Giannobile, W.V. (2020). Recombinant Human Platelet-Derived Growth Factor: A Systematic Review of Clinical Findings in Oral Regenerative Procedures. JDR Clin. Trans. Res., 2380084420921353.","DOI":"10.1177\/2380084420921353"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tripleo.2005.07.011","article-title":"Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing","volume":"101","author":"Choukroun","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/0972-124X.128261","article-title":"Bilateral multiple recession coverage with platelet-rich fibrin in comparison with amniotic membrane","volume":"18","author":"Shetty","year":"2014","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"801","DOI":"10.4103\/0972-124X.124525","article-title":"Lateral sliding bridge flap technique along with platelet rich fibrin and guided tissue regeneration for root coverage","volume":"17","author":"Agarwal","year":"2013","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1902\/jop.2015.150015","article-title":"The Adjunctive Effect of Platelet-Rich Fibrin to Connective Tissue Graft in the Treatment of Buccal Recession Defects: Results of a Randomized, Parallel-Group Controlled Trial","volume":"86","author":"Keceli","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_25","first-page":"1","article-title":"Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF)","volume":"20","author":"Schaller","year":"2020","journal-title":"Platelets"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00784-017-2211-2","article-title":"Effectiveness and predictability of titanium-prepared platelet-rich fibrin for the management of multiple gingival recessions","volume":"22","author":"Uzun","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"ref_27","unstructured":"(2020, June 11). Cochrane Handbook for Systematic Reviews of Interventions|Cochrane Training [Internet]. Available online: https:\/\/training.cochrane.org\/handbook."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: Checklist and explanations","volume":"162","author":"Hutton","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: Elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"ref_30","unstructured":"(2021, January 19). Research Registry [Internet]. Available online: https:\/\/www.researchregistry.com\/."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Methley, A.M., Campbell, S., Chew-Graham, C., McNally, R., and Cheraghi-Sohi, S. (2014). PICO, PICOS and SPIDER: A comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews. BMC Health Serv. Res., 14.","DOI":"10.1186\/s12913-014-0579-0"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1600-051X.2011.01732.x","article-title":"The interproximal clinical attachment level to classify gingival recessions and predict root coverage outcomes: An explorative and reliability study","volume":"38","author":"Cairo","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"ref_33","unstructured":"(2020, June 11). Covidence\u2014Better Systematic Review Management [Internet]. Available online: https:\/\/www.covidence.org\/home."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/01.NAJ.0000368959.11129.79","article-title":"Evidence-based practice, step by step: Asking the clinical question: A key step in evidence-based practice","volume":"110","author":"Stillwell","year":"2010","journal-title":"Am. J. Nurs."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1902\/jop.2009.090253","article-title":"Re: \u201cClinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: A 6-month study\u201d","volume":"80","author":"Sammartino","year":"2009","journal-title":"J. Periodontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4103\/ccd.ccd_571_18","article-title":"Comparative Evaluation of Treatment of Localized Gingival Recessions with Coronally Advanced Flap Using Microsurgical and Conventional Techniques","volume":"9","author":"Patel","year":"2018","journal-title":"Contemp. Clin. Dent."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4103\/jisp.jisp_387_18","article-title":"Coronally advanced flap with and without platelet-rich fibrin in the treatment of multiple adjacent recession defects: A randomized controlled split-mouth trial","volume":"23","author":"Potey","year":"2019","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5530\/jyp.2016.3.7","article-title":"Evaluation of treatment for isolated bilateral miller\u2019s class I or II gingival recession with platelet rich fibrin membrane-a comparative study","volume":"8","author":"Shivakumar","year":"2016","journal-title":"J. Young Pharm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/jcpe.12444","article-title":"Concentrated growth factor in the treatment of adjacent multiple gingival recessions: A split-mouth randomized clinical trial","volume":"42","author":"Balli","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1007\/s00784-015-1697-8","article-title":"Vascularization after treatment of gingival recession defects with platelet-rich fibrin or connective tissue graft","volume":"20","author":"Eren","year":"2016","journal-title":"Clin. Oral Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00784-017-2225-9","article-title":"Clinical evaluation of coronally advanced flap with or without platelet-rich fibrin for the treatment of multiple gingival recessions","volume":"22","author":"Kuka","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"105","DOI":"10.11607\/prd.1826","article-title":"Clinical evaluation of autologous platelet-rich fibrin in the treatment of multiple adjacent gingival recession defects: A 12-month study","volume":"35","author":"Tunaliota","year":"2015","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/0976-237X.156034","article-title":"Clinical evaluation and comparison of the efficacy of coronally advanced flap alone and in combination with platelet rich fibrin membrane in the treatment of Miller Class I and II gingival recessions","volume":"6","author":"Gupta","year":"2015","journal-title":"Contemp. Clin. Dent."},{"key":"ref_45","first-page":"41","article-title":"Use of platelet-rich fibrin membrane following treatment of gingival recession: A randomized clinical trial","volume":"32","author":"Jankovic","year":"2012","journal-title":"Int. J. Periodontics Restorative Dent."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4103\/ijdr.IJDR_22_17","article-title":"Root coverage by modified coronally advanced flap with and without platelet-rich fibrin: A clinical study","volume":"29","author":"Dixit","year":"2018","journal-title":"Indian J. Dent. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1007\/s00784-013-1170-5","article-title":"Platelet-rich fibrin in the treatment of localized gingival recessions: A split-mouth randomized clinical trial","volume":"18","author":"Eren","year":"2014","journal-title":"Clin. Oral Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/ijdr.IJDR_434_18","article-title":"Is platelet rich fibrin a viable alternative to subepithelial connective tissue graft for gingival root coverage?","volume":"31","author":"Joshi","year":"2020","journal-title":"Indian J. Dent. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4103\/ccd.ccd_70_17","article-title":"Patient-centered Microsurgical Management of Gingival Recession using Coronally Advanced Flap with Either Platelet-rich Fibrin or Connective Tissue Graft: A Comparative Analysis","volume":"8","author":"Kumar","year":"2017","journal-title":"Contemp. Clin. Dent."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4103\/ccd.ccd_325_17","article-title":"Comparative Evaluation of Platelet-Rich Fibrin with Connective Tissue Grafts in the Treatment of Miller\u2019s Class I Gingival Recessions","volume":"8","author":"Mufti","year":"2017","journal-title":"Contemp. Clin. Dent."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"265","DOI":"10.11607\/prd.2741","article-title":"The Use of Platelet-Rich Fibrin versus Subepithelial Connective Tissue Graft in Treatment of Multiple Gingival Recessions: A Randomized Clinical Trial","volume":"37","author":"Oncu","year":"2017","journal-title":"Int. J. Periodontics Restorative Dent."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"631","DOI":"10.4103\/0972-124X.119281","article-title":"A split mouth randomized controlled study to evaluate the adjunctive effect of platelet-rich fibrin to coronally advanced flap in Miller\u2019s class-I and II recession defects","volume":"17","author":"Padma","year":"2013","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/0972-124X.145790","article-title":"Comparative clinical evaluation of coronally advanced flap with or without platelet rich fibrin membrane in the treatment of isolated gingival recession","volume":"19","author":"Thamaraiselvan","year":"2015","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jds.2012.10.010","article-title":"Comparative evaluation of platelet-rich fibrin membrane and connective tissue graft in the treatment of multiple adjacent recession defects: A clinical study","volume":"10","author":"Uraz","year":"2015","journal-title":"J. Dent. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1902\/jop.2009.080253","article-title":"Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: A 6-month study","volume":"80","author":"Aroca","year":"2009","journal-title":"J. Periodontol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/JPER.18-0175","article-title":"Letter to the editor: RE: Optimized platelet-rich fibrin with the low-speed concept: Growth factor release, biocompatibility, and cellular response","volume":"90","author":"Pinto","year":"2019","journal-title":"J. Periodontol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mummolo, S., Mancini, L., Quinzi, V., D\u2019Aquino, R., Marzo, G., and Marchetti, E. (2020). Rigenera\u00ae autologous micrografts in oral regeneration: Clinical, histological, and radiographical Evaluations. Appl. Sci., 10.","DOI":"10.3390\/app10155084"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Barootchi, S., Tavelli, L., Gianfilippo, R.D., Eber, R., Stefanini, M., Zucchelli, G., and Wang, H.L. (2020). Acellular Dermal Matrix for root coverage procedures. 9-year assessment of treated isolated gingival recessions and their adjacent untreated sites. J. Periodontol.","DOI":"10.1002\/JPER.20-0310"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1902\/jop.2005.76.10.1768","article-title":"The effect of platelet-rich plasma on the coronally advanced flap root coverage procedure: A pilot human trial","volume":"76","author":"Huang","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"13334","DOI":"10.1111\/dth.13334","article-title":"Autologous platelet-rich fibrin injections in the management of facial cutaneous sinus tracts secondary to medication-related osteonecrosis of the jaw","volume":"33","author":"Bennardo","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_61","first-page":"77","article-title":"Dental extractions for patients on oral antiplatelet: A within-person randomised controlled trial comparing haemostatic plugs, advanced-platelet-rich fibrin (A-PRF+) plugs, leukocyte- and platelet-rich fibrin (L-PRF) plugs and suturing alone","volume":"12","author":"Giudice","year":"2019","journal-title":"Int. J. Oral Implantol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tripleo.2005.07.009","article-title":"Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part II: Platelet-related biologic features","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/jcpe.12590","article-title":"Clinical efficacy of coronally advanced flap with or without connective tissue graft for the treatment of multiple adjacent gingival recessions in the aesthetic area: A randomized controlled clinical trial","volume":"43","author":"Cairo","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/jcpe.12254","article-title":"Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivative for root coverage: A RCT using 3D digital measuring methods. Part II. Volumetric studies on healing dynamics and gingival dimensions","volume":"41","author":"Rebele","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"849","DOI":"10.11607\/prd.3622","article-title":"Classification of Soft Tissue Grafting Materials Based on Biologic Principles","volume":"38","author":"Yu","year":"2018","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/JPER.17-0379","article-title":"Long-term evaluation (20 years) of the outcomes of coronally advanced flap in the treatment of single recession-type defects","volume":"89","author":"Magnani","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_67","first-page":"S108","article-title":"Flap approaches in plastic periodontal and implant surgery: Critical elements in design and execution","volume":"41","author":"Clementini","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1902\/jop.2015.150420","article-title":"Use of Platelet-Rich Fibrin Membrane in the Treatment of Gingival Recession: A Systematic Review and Meta-Analysis","volume":"87","author":"Moraschini","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/jcpe.12643","article-title":"Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: Intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis","volume":"44","author":"Castro","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_70","first-page":"2587245","article-title":"The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis","volume":"2019","author":"Li","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1055\/s-0040-1701907","article-title":"Platelet-Rich Fibrin in Coverage of Gingival Recession: A Systematic Review and Meta-Analysis","volume":"14","author":"Rodas","year":"2020","journal-title":"Eur. J. Dent."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1007\/s00784-020-03400-7","article-title":"Use of platelet-rich fibrin for the treatment of gingival recessions: A systematic review and meta-analysis","volume":"24","author":"Miron","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/JPER.19-0079","article-title":"Root coverage procedures for treating single and multiple recession-type defects: A Cochrane Systematic Review Updated","volume":"90","author":"Chambrone","year":"2019","journal-title":"J. Periodontol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Panda, S., Satpathy, A., Chandra Das, A., Kumar, M., Mishra, L., Gupta, S., Srivastava, G., Lukomska-Szymanska, M., Taschieri, S., and del Fabbro, M. (2020). Additive Effect of Platelet Rich Fibrin with Coronally Advanced Flap Procedure in Root Coverage of Miller\u2019s Class I and II Recession Defects-A PRISMA Compliant Systematic Review and Meta-Analysis. 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