{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:47:35Z","timestamp":1788536855558,"version":"build-2803163510"},"reference-count":82,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PN-III-P4-ID-PCE-2020-2600"],"award-info":[{"award-number":["PN-III-P4-ID-PCE-2020-2600"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Antiresorptive or anti-angiogenic agents may induce medication-related osteonecrosis of the jaws (MRONJ), which represents a challenge for clinicians. The aim of this study is to design and apply a composed and stage-approach therapy combining antibiotherapy, surgical treatment, and photo-biomodulation (PBM) for the prevention or treatment of MRONJ lesions. Materials and Methods: The proposed treatment protocol was carried out in the Department of Oral &amp; Maxillofacial Surgery of the \u201cVictor Babes\u201d University of Medicine and Farmacy of Timisoara, in 2018\u20132020. A total of 241 patients who were previously exposed to antiresorptive or anti-angiogenic therapy, as well as patients already diagnosed with MRONJ at different stages of the disease were treated. A preventive protocol was applied for patients in an \u201cat risk\u201d stage. Patients in more advanced stages received a complex treatment. Results: The healing proved to be complete, with spontaneous bone coverage in all the n = 84 cases placed in an \u201cat risk\u201d stage. For the n = 49 patients belonging to stage 0, pain reductions and decreases of mucosal inflammations were also obtained in all cases. For the n = 108 patients proposed for surgery (i.e., in stages 1, 2, or 3 of MRONJ), a total healing rate of 91.66% was obtained after the first surgery, while considering the downscaling to stage 1 as a treatment \u201csuccess\u201d, only one \u201cfailure\u201d was reported. This brings the overall \u201csuccess\u201d rate to 96.68% for a complete healing, and to 99.59% when downscaling to stage 1 is included in the healing rate. Conclusions: Therefore, the clinical outcome of the present study indicates that patients with MRONJ in almost all stages of the disease can benefit from such a proposed association of methods, with superior clinical results compared to classical therapies.<\/jats:p>","DOI":"10.3390\/medicina57020145","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T08:33:48Z","timestamp":1612514028000},"page":"145","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Complementarity of Photo-Biomodulation, Surgical Treatment, and Antibiotherapy for Medication-Related Osteonecrosis of the Jaws (MRONJ)"],"prefix":"10.3390","volume":"57","author":[{"given":"Diana Florina","family":"Nica","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Oral Surgery, School of Dental Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy of Timisoara, 2A Eftimie Murgu Place, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-1064","authenticated-orcid":false,"given":"Mircea","family":"Rivi\u0219","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Oral Surgery, School of Dental Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy of Timisoara, 2A Eftimie Murgu Place, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3214-9278","authenticated-orcid":false,"given":"Ciprian Ioan","family":"Roi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Oral Surgery, School of Dental Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy of Timisoara, 2A Eftimie Murgu Place, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Darinca","family":"Todea","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation and Dental Emergencies, School of Dental Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy of Timisoara, 2A Eftimie Murgu Place, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-4777","authenticated-orcid":false,"given":"Virgil-Florin","family":"Duma","sequence":"additional","affiliation":[{"name":"3OM Optomechatronics Group, Faculty of Engineering, \u201cAurel Vlaicu\u201d University of Arad, 2 Elena Dragoi Str., 310177 Arad, Romania"},{"name":"Doctoral School, Polytechnic University of Timisoara, 1 Mihai Viteazu Ave., 300222 Timisoara, Romania"},{"name":"Research Center in Dental Medicine Using Conventional and Alternative Technologies, School of Dental Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy of Timisoara, 9 Revolutiei 1989 Ave., 300070 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5651-7215","authenticated-orcid":false,"given":"Cosmin","family":"Sinescu","sequence":"additional","affiliation":[{"name":"Research Center in Dental Medicine Using Conventional and Alternative Technologies, School of Dental Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy of Timisoara, 9 Revolutiei 1989 Ave., 300070 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"ref_1","first-page":"2","article-title":"Position paper on bisphosphonate-related osteonecrosis of the jaws\u20142009 update","volume":"67","author":"Ruggiero","year":"2009","journal-title":"J. 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