{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:44:44Z","timestamp":1773978284540,"version":"3.50.1"},"reference-count":10,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chiang Mai University Research Fund","award":["CMU-2564"],"award-info":[{"award-number":["CMU-2564"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>This study aims to emphasize that asymptomatic patients with undiagnosed and asymptomatic May-Thurner syndrome (MTS) may firstly develop severe compression during pregnancy. A 40-year-old woman, G1P0, at 22 weeks of twin gestation presented with left lower extremity edema and pain. One twin was structurally normal while the other had bilateral renal agenesis with oligohydramnios. Magnetic resonance venography (MRV) revealed severe compression of the left iliac vein by the right iliac artery without evidence of deep vein thrombosis (DVT). Conservative treatment with anticoagulant prophylaxis was instituted throughout the rest of pregnancy and postpartum period. She was also complicated with severe pre-eclampsia, a cesarean section was performed due to a prolapsed cord at 27 weeks of gestation, and she gave birth to a surviving baby weighing 1100 g. In conclusion, this case report provides evidence that pregnancy can disclose a subtle May-Thurner anatomy to be symptomatic without DVT. Successful pregnancy outcomes could be achieved with conservative treatment and anticoagulant prophylaxis.<\/jats:p>","DOI":"10.3390\/medicina57030222","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T10:25:18Z","timestamp":1614594318000},"page":"222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["May-Thurner Syndrome Is Aggravated by Pregnancy"],"prefix":"10.3390","volume":"57","author":[{"given":"Kuntharee","family":"Traisrisilp","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manatsawee","family":"Manopunya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanop","family":"Srisuwan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wisit","family":"Chankhunaphas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3389-6478","authenticated-orcid":false,"given":"Theera","family":"Tongsong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/000331975700800505","article-title":"The cause of the predominantly sinistral occurrence of thrombosis of the pelvic veins","volume":"8","author":"May","year":"1957","journal-title":"Angiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ejrad.2004.11.002","article-title":"Computed tomography findings in 10 cases of iliac vein compression (May-Thurner) syndrome","volume":"55","author":"Oguzkurt","year":"2005","journal-title":"Eur. J. Radiol."},{"key":"ref_3","first-page":"1044","article-title":"May-Thurner Syndrome: A Cause of Acute Left Iliac Vein Obstruction in Early Postpartum Period: A Case Report","volume":"69","author":"Inam","year":"2019","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_4","first-page":"e71","article-title":"Phlegmasia Cerulea Dolens and May-Thurner Syndrome in the first trimester of Pregnancy","volume":"6","author":"Ladha","year":"2016","journal-title":"AJP Rep."},{"key":"ref_5","first-page":"333","article-title":"May-Thurner syndrome complicating pregnancy: A report of four cases","volume":"59","author":"Wax","year":"2014","journal-title":"J. Reprod. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/j.1447-0756.2011.01840.x","article-title":"May-Thurner syndrome resulting in acute iliofemoral deep vein thrombosis during the second trimester of pregnancy","volume":"38","author":"Nakajima","year":"2012","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/jp.2014.38","article-title":"Diagnosis and management of iliac vein thrombosis in pregnancy resulting from May-Thurner Syndrome","volume":"34","author":"DeStephano","year":"2014","journal-title":"J. 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