{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:28:03Z","timestamp":1768688883373,"version":"3.49.0"},"reference-count":37,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Reverse transcriptase polymerase chain reaction (RT-PCR) negative results in the upper respiratory tract represent a major concern for the clinical management of coronavirus disease 2019 (COVID-19) patients. Herein, we report the case of a 43-years-old man with a strong clinical suspicion of COVID-19, who resulted in being negative to multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR tests performed on different oropharyngeal and nasopharyngeal swabs, despite serology having confirmed the presence of SARS-CoV-2 IgM. The patient underwent a chest computed tomography (CT) that showed typical imaging findings of COVID-19 pneumonia. The presence of viral SARS-CoV-2 was confirmed only by performing a SARS-CoV-2 RT-PCR test on stool. Performing of SARS-CoV-2 RT-PCR test on fecal samples can be a rapid and useful approach to confirm COVID-19 diagnosis in cases where there is an apparent discrepancy between COVID-19 clinical symptoms coupled with chest CT and SARS-CoV-2 RT-PCR tests\u2019 results on samples from the upper respiratory tract.<\/jats:p>","DOI":"10.3390\/medicina57030290","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T23:47:41Z","timestamp":1616370461000},"page":"290","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["SARS-CoV-2 Detection in Fecal Sample from a Patient with Typical Findings of COVID-19 Pneumonia on CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests on Oropharyngeal and Nasopharyngeal Swab Samples"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-7689","authenticated-orcid":false,"given":"Barbara","family":"Brogna","sequence":"first","affiliation":[{"name":"Department of Radiology, Moscati Hospital, Contrada Amoretta, 83100 Avellino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Brogna","sequence":"additional","affiliation":[{"name":"Specialist-Craniomed Laboratory Group srl, Viale degli Astronauti, 45, 83038 Montemiletto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-4704","authenticated-orcid":false,"given":"Mauro","family":"Petrillo","sequence":"additional","affiliation":[{"name":"European Commission, Joint Research Centre (JRC), Ispra, 21027 Via Enrico Fermi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Modestina","family":"Conte","sequence":"additional","affiliation":[{"name":"Chief U.O. Emergency Unit-OBI P.O., Pineta Grande Hospital, Via Domitiana 3000, 81030 Castel Volturno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-2915","authenticated-orcid":false,"given":"Giulio","family":"Benincasa","sequence":"additional","affiliation":[{"name":"Chief Anatomy Pathology Department, Pineta Grande Hospital, Via Domitiana 3000, 81030 Castel Volturno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5670-9439","authenticated-orcid":false,"given":"Luigi","family":"Montano","sequence":"additional","affiliation":[{"name":"Specialist Andrology Unit, Service of Lifestyle Medicine in Uro-Andrology, Local Health Authority (ASL), 84121 Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-6952","authenticated-orcid":false,"given":"Marina","family":"Piscopo","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples Federico II, 80138 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijid.2020.03.004","article-title":"The SARS-CoV-2 outbreak: What we know","volume":"94","author":"Wu","year":"2020","journal-title":"Int. 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