{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:55:11Z","timestamp":1760234111988,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Acute resistance exercise (RE) reduces vagal modulation and increases sympathovagal balance, which increases the risk for arrythmias. Few studies have examined sex differences in autonomic modulation after acute RE. The purpose of this investigation was to examine sex-specific responses to acute RE on autonomic modulation. Materials and Methods: Twenty-one resistance-trained individuals (men n = 11, women n = 10) between the ages of 19 and 25 y were analyzed for autonomic modulation in response to acute RE and a control (CON). Measures of autonomic modulation were collected at rest, 15 (R15), and 30 (R30) min following both conditions. Heart rate (HR), log transformed root mean square of successive differences (lnRMSSD), total power (lnTP), low-frequency power (lnLF), high-frequency power (lnHF), sample entropy (SampEn), and Lempel-Ziv entropy (LZEn) were measured at all time points. A three-way repeated analysis of variance (ANOVA) was used to analyze sex (men, women) across condition (RE, CON) and time (Rest, R15, R30). Results: The results are similar for all heart rate variability (HRV) variables at rest for both conditions (RE, CON). SampEn was significantly higher in men compared to women at rest for both conditions (p = 0.03), with no differences in LZEn (p &gt; 0.05). There were no significant (p &gt; 0.05) three-way interactions on any variables. Condition by time interactions demonstrated that both sexes increase in HR (p = 0.0001) and lnLF\/HF ratio (p = 0.001), but decreases in lnRMSSD (p = 0.0001), lnTP (p &lt; 0.0001), lnLF (p &lt; 0.0001), lnHF (p = 0.0001), and LZEn (p = 0.009) at R15 and R30 compared to rest following acute RE and were different from CON. Condition by time interaction (p = 0.017) demonstrated that SampEn was attenuated at R15 compared to rest, and the CON, but not R30 following acute RE. Conclusion: Although SampEn is more complex at rest in men compared to women, autonomic modulation responses between sexes following acute RE appear to be similar.<\/jats:p>","DOI":"10.3390\/medicina57040307","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T15:42:19Z","timestamp":1616600539000},"page":"307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sex-Specific Autonomic Responses to Acute Resistance Exercise"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7409-3030","authenticated-orcid":false,"given":"Stacie M.","family":"Humm","sequence":"first","affiliation":[{"name":"Cardiovascular Dynamics Laboratory, Exercise Science\/Physiology, Kent State University, Kent, OH 44242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8455-6118","authenticated-orcid":false,"given":"Emily K.","family":"Erb","sequence":"additional","affiliation":[{"name":"Cardiovascular Dynamics Laboratory, Exercise Science\/Physiology, Kent State University, Kent, OH 44242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily C.","family":"Tagesen","sequence":"additional","affiliation":[{"name":"Cardiovascular Dynamics Laboratory, Exercise Science\/Physiology, Kent State University, Kent, OH 44242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-0169","authenticated-orcid":false,"given":"J. Derek","family":"Kingsley","sequence":"additional","affiliation":[{"name":"Cardiovascular Dynamics Laboratory, Exercise Science\/Physiology, Kent State University, Kent, OH 44242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1161\/01.CIR.101.7.828","article-title":"Resistance exercise in individuals with and without cardiovascular disease: Benefits, rationale, safety, and prescription an advisory from the committee on exercise, rehabilitation, and prevention, council on clinical cardiology, American Heart Association","volume":"101","author":"Pollock","year":"2000","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-2007-965363","article-title":"Acute resistance exercise reduces heart rate complexity and increases QTc interval","volume":"29","author":"Heffernan","year":"2008","journal-title":"Int. J. Sports Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1055\/s-0034-1371836","article-title":"Autonomic modulation in resistance-trained individuals after acute resistance exercise","volume":"35","author":"Kingsley","year":"2014","journal-title":"Int. J. Sports Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/cpf.12223","article-title":"Acute and training effects of resistance exercise on heart rate variability","volume":"36","author":"Kingsley","year":"2016","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.23736\/S0022-4707.18.08864-3","article-title":"Autonomic modulation and baroreflex sensitivity after acute resistance exercise: Responses between sexes","volume":"59","author":"Kingsley","year":"2019","journal-title":"J. Sports Med. Phys. Fitness"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/01.hjr.0000197470.74070.46","article-title":"Cardiac autonomic modulation during recovery from acute endurance versus resistance exercise","volume":"13","author":"Heffernan","year":"2006","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","volume":"93","author":"Camm","year":"1996","journal-title":"Circulation"},{"key":"ref_8","first-page":"H773","article-title":"Nonlinear methods of biosignal analysis in assessing terbutaline-induced heart rate and blood pressure changes","volume":"282","author":"Kuusela","year":"2002","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/europace\/eul031","article-title":"Decrease in the heart rate complexity prior to the onset of atrial fibrillation","volume":"8","author":"Tuzcu","year":"2006","journal-title":"Europace"},{"key":"ref_10","first-page":"H3180","article-title":"Heart rate recovery and heart rate complexity following resistance exercise training and detraining in young men","volume":"293","author":"Heffernan","year":"2007","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1007\/s00421-010-1811-1","article-title":"Post-concurrent exercise hemodynamics and cardiac autonomic modulation","volume":"111","author":"Teixeira","year":"2011","journal-title":"Eur. J. Appl. Phys."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Voss, A., Schroeder, R., Heitmann, A., Peters, A., and Perz, S. (2015). Short-term heart rate variability\u2014influence of gender and age in healthy subjects. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118308"},{"key":"ref_13","first-page":"455","article-title":"Heart rate variability at rest and exercise: Influence of age, gender, and physical training","volume":"21","author":"Gregoire","year":"1996","journal-title":"Can. J. Appl. Phys."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1139\/H10-028","article-title":"Sex differences in linear and nonlinear heart rate variability during early recovery from supramaximal exercise","volume":"35","author":"Mendonca","year":"2010","journal-title":"Appl. Phys. Nutr. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.genm.2008.06.002","article-title":"Sex differences in the effects of aerobic and anaerobic exercise on blood pressure and arterial stiffness","volume":"5","author":"Collier","year":"2008","journal-title":"Gend. Med."},{"key":"ref_16","unstructured":"American College of Sports Medicine, Riebe, D., Ehrman, J.K., Liguori, G., and Magal, M. (2018). ACSM\u2019s Guidelines for Exercise Testing and Prescription, Wolters Kluwer. [10th ed.]."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1249\/00005768-199301000-00013","article-title":"Validity and reliability of self-reported physical activity status: The Lipid Research Clinics questionnaire","volume":"25","author":"Ainsworth","year":"1993","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"14568","DOI":"10.1038\/s41598-018-32647-0","article-title":"Menstrual cycle rhythmicity: Metabolic patterns in healthy women","volume":"8","author":"Draper","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_19","unstructured":"Haff, G.G., and Triplett, N.T. (2015). Essentials of Strength Training and Conditioning, Human Kinetics. [4th ed.]."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1249\/MSS.0000000000001487","article-title":"Sex differences in cardiac baroreflex sensitivity following isometric handgrip exercise","volume":"50","author":"Teixeira","year":"2018","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/MAJ.0b013e31824ba080","article-title":"Sympathovagal imbalance in young prehypertensives: Importance of male-female difference","volume":"345","author":"Pal","year":"2013","journal-title":"Am. J. Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"399","DOI":"10.12965\/jer.1836136.068","article-title":"Postexercise hypotension and autonomic modulation response after full versus split body resistance exercise in trained men","volume":"14","author":"Quizzini","year":"2018","journal-title":"J. Exerc. Rehabil."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1249\/00005768-199405000-00008","article-title":"Exercise and aging: Autonomic control of the circulation","volume":"26","author":"Seals","year":"1994","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1519\/JSC.0000000000001347","article-title":"Exercise type affects cardiac vagal autonomic recovery after a resistance training session","volume":"30","author":"Mayo","year":"2016","journal-title":"J. Strength Cond. Res."},{"key":"ref_25","first-page":"446","article-title":"Influence of age and moderate-intensity exercise training on heart rate variability in young and mature adults","volume":"28","author":"Leicht","year":"2003","journal-title":"Can. J. Appl. Phys."},{"key":"ref_26","first-page":"67","article-title":"Heart rate variability in physically active individuals: Reliability and gender characteristics","volume":"23","author":"Sookan","year":"2012","journal-title":"Cardiovasc. J. Afr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fphys.2013.00026","article-title":"The LF\/HF ratio does not accurately measure cardiac sympatho-vagal balance","volume":"4","author":"Billman","year":"2013","journal-title":"Front. Phys."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/4\/307\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:40:41Z","timestamp":1760161241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/4\/307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["medicina57040307"],"URL":"https:\/\/doi.org\/10.3390\/medicina57040307","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2021,3,24]]}}}