{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:43:10Z","timestamp":1762177390213,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: Parkinson\u2019s disease (PD) is the second most common neurodegenerative disorder. This disease is characterized by motor symptoms, such as bradykinesia, tremor, and rigidity. Although balance impairment is characteristic of advanced stages, it can be present with less intensity since the beginning of the disease. Approximately 60% of PD patients fall once a year and 40% recurrently. On the other hand, cognitive symptoms affect up to 20% of patients with PD in early stages and can even precede the onset of motor symptoms. There are cognitive requirements for balance and can be challenged when attention is diverted or reduced, linking a worse balance and a higher probability of falls with a slower cognitive processing speed and attentional problems. Cognitive rehabilitation of attention and processing speed can lead to an improvement in postural stability in patients with Parkinson\u2019s. Methods: We present a parallel and controlled randomized clinical trial (RCT) to assess the impact on balance of a protocol based on cognitive rehabilitation focused on sustained attention through the NeuronUP platform (Neuronup SI, La Rioja, Spain) in patients with PD. For 4 weeks, patients in the experimental group will receive cognitive therapy three days a week while the control group will not receive any therapy. The protocol has been registered at trials.gov NCT04730466. Conclusions: Cognitive therapy efficacy on balance improvement may open the possibility of new rehabilitation strategies for prevention of falls in PD, reducing morbidity, and saving costs to the health care system.<\/jats:p>","DOI":"10.3390\/medicina57040314","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T13:17:53Z","timestamp":1616764673000},"page":"314","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients with Parkinson\u2019s Disease: Study Protocol for a Randomized Controlled Trial"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8704-242X","authenticated-orcid":false,"given":"Aida","family":"Arroyo-Ferrer","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, 28223 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-7071","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"S\u00e1nchez-Cuesta","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, 28223 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeray","family":"Gonz\u00e1lez-Zamorano","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, 28223 Madrid, Spain"},{"name":"Escuela Internacional de Doctorado, Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorc\u00f3n, 28933 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-4484","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"del Castillo","sequence":"additional","affiliation":[{"name":"Neural and Cognitive Engineering Group, Centre for Automation and Robotics, Spanish National Research Council\u2014Arganda del Rey, 28500 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Sastre-Barrios","sequence":"additional","affiliation":[{"name":"Neuronup SL, 26006 Logro\u00f1o, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-5047","authenticated-orcid":false,"given":"Marcos","family":"R\u00edos-Lago","sequence":"additional","affiliation":[{"name":"Basic Psychology II Department, UNED, 28040 Madrid, Spain"},{"name":"Brain Damage Unit, Hospital Beata Mar\u00eda Ana, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3190-1296","authenticated-orcid":false,"given":"Juan Pablo","family":"Romero","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarc\u00f3n, 28223 Madrid, Spain"},{"name":"Brain Damage Unit, Hospital Beata Mar\u00eda Ana, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.5604\/12321966.1232774","article-title":"Motor Assessment in Parkinson\u2019s Disease","volume":"24","author":"Opara","year":"2017","journal-title":"Ann. 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