{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:48:47Z","timestamp":1760402927758,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: As the COVID-19 pandemic spreads, it is becoming increasingly evident that this coronavirus is not limited to the respiratory system and that the musculoskeletal system can also be affected. The purpose of the present study was to describe non-respiratory symptoms of laboratory-confirmed COVID-19 cases. Materials and Methods: All patients with SARS-CoV-2 admitted to our hospital, between 1 August and 30 September 2020, were included in this retrospective study. Data were extracted from medical records. Epidemiological, clinical, laboratory and radiological characteristics at the initial presentation at the hospital were collected and analyzed. Results: A total of 79 COVID-19 patients were enrolled. The mean age of the patients was 44.08 years (age range, 18\u201387 years) and 59.5% were male. The most common symptoms were fatigue in 60 (75.9%) patients, followed by fever (73.4%), myalgia (51.9%), cough (41.8%), anosmia (38%) and arthralgia (36.7%). The muscles of the upper back and the knee joint were the most painful anatomic region and joint, respectively. The laboratory findings on admission showed that D-dimer, CRP and procalcitonin levels were increased, without significant gender differences (p &gt; 0.05). Chest imaging demonstrated pneumonia in 20 (25.3%) patients. Conclusions: Our results indicate that from the onset of the symptoms of COVID-19 patients, musculoskeletal symptoms, such as fatigue, myalgia and arthralgia, were present in three-quarters of all patients. These findings could help elaborate updated triage and admission protocols for suspect COVID-19 patients at the hospital and Emergency Department presentation.<\/jats:p>","DOI":"10.3390\/medicina57040344","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T10:34:09Z","timestamp":1617359649000},"page":"344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Non-Respiratory Symptoms of Patients Infected with SARS-CoV-2 (Coronavirus Disease 2019): Lessons from Their Initial Presentation at the Hospital"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6155-8898","authenticated-orcid":false,"given":"Angelo V.","family":"Vasiliadis","sequence":"first","affiliation":[{"name":"2nd Orthopaedic Department, General Hospital of Thessaloniki \u201cPapageorgiou\u201d, 56403 Thessaloniki, Greece"},{"name":"School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tsatlidou","sequence":"additional","affiliation":[{"name":"2nd Orthopaedic Department, General Hospital of Thessaloniki \u201cPapageorgiou\u201d, 56403 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Metaxiotis","sequence":"additional","affiliation":[{"name":"2nd Orthopaedic Department, General Hospital of Thessaloniki \u201cPapageorgiou\u201d, 56403 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampos","family":"Psomiadis","sequence":"additional","affiliation":[{"name":"Infection Control Unit, General Hospital of Thessaloniki \u201cPapageorgiou\u201d, 56403 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios","family":"Beletsiotis","sequence":"additional","affiliation":[{"name":"2nd Orthopaedic Department, General Hospital of Thessaloniki \u201cPapageorgiou\u201d, 56403 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kostoula","family":"Arvaniti","sequence":"additional","affiliation":[{"name":"Infection Control Unit, General Hospital of Thessaloniki \u201cPapageorgiou\u201d, 56403 Thessaloniki, Greece"},{"name":"COVID-19 Coordination Team, General Hospital of Thessaloniki \u201cPapageorgiou\u201d, 56403 Thessaloniki, Greece"},{"name":"Critical Care Department, General Hospital of Thessaloniki \u201cPapageorgiou\u201d, 56403 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3389\/fneur.2020.00687","article-title":"Neurological and musculoskeletal features of COVID-19: A systematic review and meta-analysis","volume":"11","author":"Abdullahi","year":"2020","journal-title":"Front. 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