{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:11:25Z","timestamp":1793394685132,"version":"4.5.0"},"reference-count":111,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Porcine xenografts have been used successfully in partial thickness burn treatment for many years. Their disappearance from the market led to the search for effective and efficient alternatives. In this article, we examine the synthetic epidermal skin substitute Suprathel\u00ae as a substitute in the treatment of partial thickness burns. Materials and Methods: A systematic review following the PRISMA guidelines has been performed. Sixteen Suprathel\u00ae and 12 porcine xenograft studies could be included. Advantages and disadvantages between the treatments and the studies\u2019 primary endpoints have been investigated qualitatively and quantitatively. Results: Although Suprathel had a nearly six times larger TBSA in their studies (p &lt; 0.001), it showed a significantly lower necessity for skin grafts (p &lt; 0.001), and we found a significantly lower infection rate (p &lt; 0.001) than in Porcine Xenografts. Nonetheless, no significant differences in the healing time (p = 0.67) and the number of dressing changes until complete wound healing (p = 0.139) could be found. Both products reduced pain to various degrees with the impression of a better performance of Suprathel\u00ae on a qualitative level. Porcine xenograft was not recommended for donor sites or coverage of sheet-transplanted keratinocytes, while Suprathel\u00ae was used successfully in both indications. Conclusion: The investigated parameters indicate that Suprathel\u00ae to be an effective replacement for porcine xenografts with even lower subsequent treatment rates. Suprathel\u00ae appears to be usable in an extended range of indications compared to porcine xenograft. Data heterogeneity limited conclusions from the results.<\/jats:p>","DOI":"10.3390\/medicina57050432","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T10:53:29Z","timestamp":1619780009000},"page":"432","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Porcine Xenograft and Epidermal Fully Synthetic Skin Substitutes in the Treatment of Partial-Thickness Burns: A Literature Review"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4996-4199","authenticated-orcid":false,"given":"Herbert L.","family":"Haller","sequence":"first","affiliation":[{"name":"HLMedConsult, Zehetlandweg 7, 4060 Leonding, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid E.","family":"Blome-Eberwein","sequence":"additional","affiliation":[{"name":"Lehigh Valley Health Network 1200 S. Cedar Crest Blvd. Kasych 3000, Allentown, PA 18103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwik K.","family":"Branski","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2014Burn Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, 301 University BLVD, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Surgery, UF Health Shands Burn Center, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1806-3021","authenticated-orcid":false,"given":"Roselle E.","family":"Crombie","sequence":"additional","affiliation":[{"name":"Connecticut Burn Center, Yale New Haven Heal System, 267 Grant St, Bridgeport, CT 06610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Hickerson","sequence":"additional","affiliation":[{"name":"Memphis Medical Center Burn Center, 890 Madison Avenue, Suite TG032, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Peter","family":"Kamolz","sequence":"additional","affiliation":[{"name":"Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University, 8053 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Booker T.","family":"King","sequence":"additional","affiliation":[{"name":"Division of Burn Surgery, Department of Surgery, 101 Manning Drive CB #7206, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6621-4891","authenticated-orcid":false,"given":"Sebastian P.","family":"Nischwitz","sequence":"additional","affiliation":[{"name":"Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University, 8053 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Popp","sequence":"additional","affiliation":[{"name":"Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University, 8053 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Shupp","sequence":"additional","affiliation":[{"name":"The Burn Center, Department of Surgery, MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-3440","authenticated-orcid":false,"given":"Steven E.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Lehigh Valley Health Network 1200 S. Cedar Crest Blvd. Kasych 3000, Allentown, PA 18103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hozo, S.P., Djulbegovic, B., and Hozo, I. (2005). Estimating the mean and variance from the median, range, and the size of a sample. BMC Med. Res. Methodol., 5.","DOI":"10.1186\/1471-2288-5-13"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1177\/01632780122034885","article-title":"Simple pooling versus combining in meta-analysis","volume":"24","author":"Bravata","year":"2001","journal-title":"Eval. Health Prof."},{"key":"ref_3","unstructured":"(2021, March 15). Two Sample T-Test (Welch\u2019s T-test) n.d. 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