{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:32:47Z","timestamp":1777415567517,"version":"3.51.4"},"reference-count":16,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Cardiac amyloidosis (CA) is a rare systemic disease determined by the extracellular deposition of amyloid protein in the heart. The protein can accumulate in any part of the heart: myocardium, vessels, endocardium, valves, epicardium and parietal pericardium. The types of CA include the following types: light chain (AL), amyloidosis AA (Amyloid A) and transthyretin (ATTR). The detection of specific subtypes remains of great importance to implement the targeted treatment. We present the case of a 65-year-old woman, who was admitted with severe deterioration of exercise capacity, a bilateral reduction of physiological vesicular murmur, ascites and edema of lower extremities. CA was suspected due to echocardiographic examination results, which led to further examination and final diagnosis. The aim of this study is to improve the disease awareness among clinicians and shorten the delay between the first symptoms and the diagnosis establishment resulting in a better outcome.<\/jats:p>","DOI":"10.3390\/medicina57050450","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T02:15:13Z","timestamp":1620267313000},"page":"450","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac Amyloidosis-Challenging Diagnosis and Unclear Clinical Picture"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5226-5006","authenticated-orcid":false,"given":"Sylwia","family":"Kozak","sequence":"first","affiliation":[{"name":"Student Scientific Society at the Department of Internal, Autoimmune and Metabolic Diseases, School of Medicine, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-1541","authenticated-orcid":false,"given":"Krzysztof","family":"Ulbrich","sequence":"additional","affiliation":[{"name":"Student Scientific Society at the Department of Internal, Autoimmune and Metabolic Diseases, School of Medicine, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5143-0030","authenticated-orcid":false,"given":"Maciej","family":"Migacz","sequence":"additional","affiliation":[{"name":"Department of Internal, Autoimmune and Metabolic Diseases, School of Medicine, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Szyd\u0142o","sequence":"additional","affiliation":[{"name":"1st Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6907-2799","authenticated-orcid":false,"given":"Katarzyna","family":"Mizia-Stec","sequence":"additional","affiliation":[{"name":"1st Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3289-1050","authenticated-orcid":false,"given":"Micha\u0142","family":"Holecki","sequence":"additional","affiliation":[{"name":"Department of Internal, Autoimmune and Metabolic Diseases, School of Medicine, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/clc.23572","article-title":"Cardiac amyloidosis\u2014A review of current literature for the practicing physician","volume":"44","author":"Ash","year":"2021","journal-title":"Clin. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bistola, V., Parissis, J., Foukarakis, E., Valsamaki, P.N., Anastasakis, A., Koutsis, G., Efthimiadis, G., and Kastritis, E. (2021). Practical recommendations for the diagnosis and management of transthyretin cardiac amyloidosis. Hear. Fail. Rev., 1\u201319.","DOI":"10.1007\/s10741-020-10062-w"},{"key":"ref_3","first-page":"616","article-title":"Amyloidoza serca\u2014W\u0142a\u015bciwe rozpoznanie i nowe terapie na horyzoncie","volume":"14","author":"Holcman","year":"2019","journal-title":"Folia Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s12471-019-1299-1","article-title":"Cardiac amyloidosis: The need for early diagnosis","volume":"27","author":"Oerlemans","year":"2019","journal-title":"Neth. Hear. 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