{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T20:57:37Z","timestamp":1764277057673,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss national science Foundation","award":["IZERZ0_142305"],"award-info":[{"award-number":["IZERZ0_142305"]}]},{"name":"UEFISCDI","award":["1420-CH\/RSRP"],"award-info":[{"award-number":["1420-CH\/RSRP"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Mycosis fungoides (MF) and large plaque parapsoriasis (LPP) evolution provide intriguing data and are the cause of numerous debates. The diagnosis of MF and LPP is associated with confusion and imprecise definition. Copy number alterations (CNAs) may play an essential role in the genesis of cancer out of genes expression dysregulation. Objectives: Due to the heterogeneity of MF and LPP and the scarcity of the cases, there are an exceedingly small number of studies that have identified molecular changes in these pathologies. We aim to identify and compare DNA copy number alterations and gene expression changes between MF and LPP to highlight the similarities and the differences between these pathologies. Materials and Methods: The patients were prospectively selected from University Clinic of Dermatology and Venereology Timi\u0219oara, Romania. From fresh frozen skin biopsies, we extracted DNA using single nucleotide polymorphism (SNP) data. The use of SNP array for copy number profiling is a promising approach for genome-wide analysis. Results: After reviewing each group, we observed that the histograms generated for chromosome 1\u201322 were remarkably similar and had a lot of CNAs in common, but also significant differences were seen. Conclusions: This study took a step forward in finding out the differences and similarities between MF and LPP, for a more specific and implicitly correct approach of the case. The similarity between these two pathologies in terms of CNAs is striking, emphasizing once again the difficulty of approaching and differentiating them.<\/jats:p>","DOI":"10.3390\/medicina57050502","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T23:17:16Z","timestamp":1621207036000},"page":"502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["From Benign Inflammatory Dermatosis to Cutaneous Lymphoma. DNA Copy Number Imbalances in Mycosis Fungoides versus Large Plaque Parapsoriasis"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0668-5488","authenticated-orcid":false,"given":"Georgiana","family":"Gug","sequence":"first","affiliation":[{"name":"Research Center for the Morphologic Study of the Skin, Department of Dermatology and Venereology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caius","family":"Solovan","sequence":"additional","affiliation":[{"name":"Research Center for the Morphologic Study of the Skin, Department of Dermatology and Venereology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Emergency City Hospital, University Clinic of Dermatology and Venereology, 300558 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"ref_1","unstructured":"(2020, June 26). Available online: http:\/\/emedicine.medscape.com\/article\/2139720-overview#a4."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Fujii, K., and Kanekura, T. (2019). Next-Generation sequencing technologies for early-stage cutaneous T-Cell Lymphoma. Front. Med., 6.","DOI":"10.3389\/fmed.2019.00181"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zackheim, H.S. (2004). Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome, CRC Press. 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