{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:02:39Z","timestamp":1760234559194,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: Squamous cell carcinoma (SCC) is one of the most common neoplasms affecting the oral cavity and the face. Its more differentiated forms may be associated with human papilloma virus (HPV) infection. Case report: In this paper, we report the case of an 86-year-old patient with a well-differentiated SCC of the lower lip associated with HPV treated with surgery with a non-complete histological resolution. Imiquimod 5% cream was applied on the surgical scar once a day for two weeks and then once a week. Two years after SCC removal, no relapse has occurred. Conclusions: Topical imiquimod may be a safe and effective treatment after surgery in SCC of the oral area to reduce the risk of relapses.<\/jats:p>","DOI":"10.3390\/medicina57060563","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T10:38:39Z","timestamp":1622630319000},"page":"563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip"],"prefix":"10.3390","volume":"57","author":[{"given":"Giovanni","family":"Pentangelo","sequence":"first","affiliation":[{"name":"Unit of Oral Surgery, Polla Hospital, 84035 Polla, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Paul","family":"Nistic\u00f2","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Magna Graecia University, Viale Europa, SNC, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Provenzano","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Annunziata Hospital, 87100 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giusy Ylenia","family":"Cisale","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Sapienza University of Rome, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-1027","authenticated-orcid":false,"given":"Luigi","family":"Bennardo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Magna Graecia University, Viale Europa, SNC, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3747\/co.27.5873","article-title":"Organizational Guidance for the Care of Patients with Head-and-Neck Cancer in Ontario","volume":"27","author":"Irish","year":"2020","journal-title":"Curr. 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