{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:19:47Z","timestamp":1793398787386,"version":"4.5.0"},"reference-count":20,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: In this study, we aimed to evaluate whether the systemic immune-inflammation index (SII) has a prognostic value for major adverse cardiac events (MACEs), including stroke, re-hospitalization, and short-term all-cause mortality at 6 months, in aortic stenosis (AS) patients who underwent transcatheter aortic valve implantation (TAVI). Materials and Methods: A total of 120 patients who underwent TAVI due to severe AS were retrospectively included in our study. The main outcome of the study was MACEs and short-term all-cause mortality at 6 months. Results: The SII was found to be higher in TAVI patients who developed MACEs than in those who did not develop them. Multivariate Cox regression analysis revealed that the SII (HR: 1.002, 95%CI: 1.001\u20131.003, p &lt; 0.01) was an independent predictor of MACEs in AS patients after TAVI. The optimal value of the SII for MACEs in AS patients following TAVI was &gt;1.056 with 94% sensitivity and 96% specificity (AUC (the area under the curve): 0.960, p &lt; 0.01). We noted that the AUC value of SII in predicting MACEs was significantly higher than the AUC value of the C-reactive protein (AUC: 0.960 vs. AUC: 0.714, respectively). Conclusions: This is the first study to show that high pre-procedural SII may have a predictive value for MACEs and short-term mortality in AS patients undergoing TAVI.<\/jats:p>","DOI":"10.3390\/medicina57060588","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T12:08:55Z","timestamp":1623154135000},"page":"588","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Prognostic Value of Systemic Immune-Inflammation Index for Major Adverse Cardiac Events and Mortality in Severe Aortic Stenosis Patients after TAVI"],"prefix":"10.3390","volume":"57","author":[{"given":"Aydin Rodi","family":"Tosu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Haseki Training and Research Hospital, University of Health Sciences, 34130 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-0942","authenticated-orcid":false,"given":"Muhsin","family":"Kalyoncuoglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haseki Training and Research Hospital, University of Health Sciences, 34130 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil \u0130brahim","family":"Biter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haseki Training and Research Hospital, University of Health Sciences, 34130 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-4584","authenticated-orcid":false,"given":"Sinem","family":"Cakal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haseki Training and Research Hospital, University of Health Sciences, 34130 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Selcuk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sultan II. Abd\u00fclhamid Han Training and Research Hospital, University of Health Sciences, 34668 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8188-5020","authenticated-orcid":false,"given":"Tufan","family":"\u00c7inar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sultan II. Abd\u00fclhamid Han Training and Research Hospital, University of Health Sciences, 34668 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Belen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haseki Training and Research Hospital, University of Health Sciences, 34130 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Mustafa","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haseki Training and Research Hospital, University of Health Sciences, 34130 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/heartjnl-2012-302265","article-title":"The evolving epidemiology of valvular aortic stenosis. the Troms\u00f8 study","volume":"99","author":"Eveborn","year":"2013","journal-title":"Heart"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/S0735-1097(01)01484-X","article-title":"C-reactive protein is increased in patients with degenerative aortic valvular stenosis","volume":"38","author":"Galante","year":"2001","journal-title":"J. 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