{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:20:59Z","timestamp":1773285659268,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Chances of surviving sepsis increase markedly upon prompt diagnosis and treatment. As most sepsis cases initially show-up in the Emergency Department (ED), early recognition of a septic patient has a pivotal role in sepsis management, despite the lack of precise guidelines. The aim of this study was to identify the most accurate predictors of in-hospital mortality outcome in septic patients admitted to the ED. Materials and Methods: We compared 651 patients admitted to ED for sepsis (cases) with 363 controls (non-septic patients). A Bayesian mean multivariate logistic regression model was performed in order to identify the most accurate predictors of in-hospital mortality outcomes in septic patients. Results: Septic shock and positive qSOFA were identified as risk factors for in-hospital mortality among septic patients admitted to the ED. Hyperthermia was a protective factor for in-hospital mortality. Conclusions: Physicians should bear in mind that fever is not a criterium for defining sepsis; according to our results, absence of fever upon presentation might be indicative of greater severity and diagnosis of sepsis should not be delayed.<\/jats:p>","DOI":"10.3390\/medicina57060612","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T22:25:46Z","timestamp":1623709546000},"page":"612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recognition in Emergency Department of Septic Patients at Higher Risk of Death: Beware of Patients without Fever"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6247-5958","authenticated-orcid":false,"given":"Emanuela","family":"Sozio","sequence":"first","affiliation":[{"name":"Infectious Disease Unit, Azienda Sanitaria Universitaria Integrata di Udine (ASU FC), 33100 Udine, Italy"},{"name":"Department of Medicine (DAME), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Bertini","sequence":"additional","affiliation":[{"name":"Emergency Department, North-West District, Tuscany Health Care, Spedali Riuniti Livorno, 57124 Livorno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1791-8718","authenticated-orcid":false,"given":"Giacomo","family":"Bertolino","sequence":"additional","affiliation":[{"name":"Department of Public Health, Clinical and Molecular Medicine, Universit\u00e0 degli Studi di Cagliari, 09124 Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-0373","authenticated-orcid":false,"given":"Francesco","family":"Sbrana","sequence":"additional","affiliation":[{"name":"U.O. Lipoaferesi, Fondazione Toscana \u201cGabriele Monasterio\u201d, Via Moruzzi,1, 1, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ripoli","sequence":"additional","affiliation":[{"name":"Deep Health Unit, Fondazione Toscana \u201cGabriele Monasterio\u201d, Via Moruzzi, 1, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1378-1649","authenticated-orcid":false,"given":"Fabio","family":"Carfagna","sequence":"additional","affiliation":[{"name":"SIMNOVA-Interdepartment Centre for Innovative Teaching and Simulation in Medicine and the Health Professions (Centro Interdipartimentale di Didattica Innovativa e di Simulazione in Medicina e Professioni Sanitarie), University of Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Giacinta","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Azienda Sanitaria Universitaria Integrata di Udine (ASU FC), 33100 Udine, Italy"},{"name":"Department of Medicine (DAME), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Viaggi","sequence":"additional","affiliation":[{"name":"Neuro Intensive Care Unit, Department of Anesthesia, Careggi Universital Hospital, 50139 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8711-8305","authenticated-orcid":false,"given":"Simone","family":"Meini","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Felice Lotti Hospital, Pontedera, Azienda USL Toscana Nord-Ovest, 1, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Ghiadoni","sequence":"additional","affiliation":[{"name":"Emergency Medicine, University Hospital of Pisa, 56124 Pisa, Italy"},{"name":"Department of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9625-6024","authenticated-orcid":false,"given":"Carlo","family":"Tascini","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Azienda Sanitaria Universitaria Integrata di Udine (ASU FC), 33100 Udine, Italy"},{"name":"Department of Medicine (DAME), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13049-017-0449-y","article-title":"Low sensitivity of qSOFA, SIRS criteria and sepsis definition to identify infected patients at risk of complication in the prehospital setting and at the emergency department triage","volume":"25","author":"Tusgul","year":"2017","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The accp\/sccm consensus conference committee. american college of chest physicians\/society of crit care med","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00134-003-1662-x","article-title":"2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference","volume":"29","author":"Levy","year":"2003","journal-title":"Intensive Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/jama.2016.0289","article-title":"Developing a new definition and assessing new clinical criteria for septic shock: For the third international consensus Definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Phillips","year":"2016","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/jama.2016.0736","article-title":"New sepsis diagnostic guidelines shift focus to organ dysfunction","volume":"315","author":"Jacob","year":"2016","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajem.2015.08.039","article-title":"Triage sepsis alert and sepsis protocol lower times to fluids and antibiotics in the ed","volume":"34","author":"Hayden","year":"2016","journal-title":"Am. J. Emerg. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4081\/itjm.2016.803","article-title":"Sepsis and septic shock: A practical management according to Sepsis-3 diagnostic criteria","volume":"10","year":"2016","journal-title":"Ital. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.annemergmed.2016.10.007","article-title":"Quick sofa scores predict mortality in adult emergency department patients with and without suspected infection","volume":"69","author":"Singer","year":"2017","journal-title":"Ann. Emerg. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jcrc.2017.10.023","article-title":"Comparison of the performance of SOFA, qSOFA and SIRS for predicting mortality and organ failure among sepsis patients admitted to the intensive care unit in a middle-income country","volume":"44","author":"Khwannimit","year":"2018","journal-title":"J. Crit. Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-017-1658-5","article-title":"Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit","volume":"21","author":"Finkelsztein","year":"2017","journal-title":"Crit. Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1001\/jama.2016.20329","article-title":"Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department","volume":"317","author":"Freund","year":"2017","journal-title":"JAMA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1001\/jama.2016.20328","article-title":"Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit","volume":"317","author":"Raith","year":"2017","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1164\/rccm.201604-0854OC","article-title":"Quick Sepsis-related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients outside the Intensive Care Unit","volume":"195","author":"Churpek","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jcrc.2017.05.017","article-title":"A comparison of pre icu admission sirs, ews and q sofa scores for predictingmortality and length of stay in icu","volume":"41","author":"Siddiqui","year":"2017","journal-title":"J. Crit. Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.chest.2017.12.015","article-title":"A comparison of the quick-sofa and systemic inflammatory response syndrome criteria for the diagnosis of sepsis and prediction of mortality: A systematic review and meta-analysis","volume":"153","author":"Serafim","year":"2018","journal-title":"Chest"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1097\/CCM.0b013e31827c09f8","article-title":"Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*","volume":"41","author":"Gaieski","year":"2013","journal-title":"Crit. Care Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit. Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/CCM.0000000000002255","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016","volume":"45","author":"Rhodes","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1002\/sim.1930","article-title":"Comparison of Bayesian model averaging and stepwise methods for model selection in logistic regression","volume":"23","author":"Wang","year":"2004","journal-title":"Stat. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock","volume":"345","author":"Rivers","year":"2001","journal-title":"New Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.annemergmed.2005.04.007","article-title":"Emergency Medicine and the Surviving Sepsis Campaign: An International Approach to Managing Severe Sepsis and Septic Shock","volume":"46","author":"Osborn","year":"2005","journal-title":"Ann. Emerg. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1001\/jama.2015.1410","article-title":"Readmission Diagnoses After Hospitalization for Severe Sepsis and Other Acute Medical Conditions","volume":"313","author":"Prescott","year":"2015","journal-title":"JAMA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for sepsis: For the third international consensus Definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1136\/emj.2010.095067","article-title":"The sepsis six and the severe sepsis resuscitation bundle: A prospective observational cohort study","volume":"28","author":"Daniels","year":"2010","journal-title":"Emerg. Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/CCM.0000000000000330","article-title":"Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: Results from a guideline-based performance improvement program","volume":"42","author":"Ferrer","year":"2014","journal-title":"Crit. Care Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0891-5520(05)70282-8","article-title":"THE ADAPTIVE VALUE OF FEVER","volume":"10","author":"Kluger","year":"1996","journal-title":"Infect. Dis. Clin. North Am."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.7326\/0003-4819-120-12-199406150-00010","article-title":"Fever: Blessing or curse? a unify-ing hypothesis","volume":"120","author":"Mackowiak","year":"1994","journal-title":"Ann. Intern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Rumbus, Z., Matics, R., Hegyi, P., Zsiboras, C., Szabo, I., Illes, A., Petervari, E., Balasko, M., Marta, K., and Miko, A. (2017). Fever Is Associated with Reduced, Hypothermia with Increased Mortality in Septic Patients: A Meta-Analysis of Clinical Trials. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170152"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"R271","DOI":"10.1186\/cc13106","article-title":"The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: An analysis from a multicenter, prospective survey of severe sepsis","volume":"17","author":"Kushimoto","year":"2013","journal-title":"Crit. Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e575","DOI":"10.1097\/CCM.0000000000002311","article-title":"The absence of fever is associated with higher mortality and decreased antibiotic and iv fluid administration in emergency department patients with suspected septic shock","volume":"45","author":"Henning","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/01.ccm.0000529485.65268.b2","article-title":"1483: Monocyte function and clinical outcomes in febrile and afebrile patients with severe sepsis","volume":"46","author":"Drewry","year":"2018","journal-title":"Crit. Care Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/6\/612\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:13:36Z","timestamp":1760163216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/6\/612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,12]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["medicina57060612"],"URL":"https:\/\/doi.org\/10.3390\/medicina57060612","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,12]]}}}