{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:02:42Z","timestamp":1792609362296,"version":"4.5.0"},"reference-count":60,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Lactobacillus reuteri DSM 17938 (L. reuteri) is a probiotic that can colonize different human body sites, including primarily the gastrointestinal tract, but also the urinary tract, the skin, and breast milk. Literature data showed that the administration of L. reuteri can be beneficial to human health. The aim of this review was to summarize current knowledge on the role of L. reuteri in the management of gastrointestinal symptoms, abdominal pain, diarrhea and constipation, both in adults and children, which are frequent reasons for admission to the emergency department (ED), in order to promote the best selection of probiotic type in the treatment of these uncomfortable and common symptoms. Materials and Methods: We searched articles on PubMed\u00ae from January 2011 to January 2021. Results: Numerous clinical studies suggested that L. reuteri may be helpful in modulating gut microbiota, eliminating infections, and attenuating the gastrointestinal symptoms of enteric colitis, antibiotic-associated diarrhea (also related to the treatment of Helicobacter pylori (HP) infection), irritable bowel syndrome, inflammatory bowel disease, and chronic constipation. In both children and in adults, L. reuteri shortens the duration of acute infectious diarrhea and improves abdominal pain in patients with colitis or inflammatory bowel disease. It can ameliorate dyspepsia and symptoms of gastritis in patients with HP infection. Moreover, it improves gut motility and chronic constipation. Conclusion: Currently, probiotics are widely used to prevent and treat numerous gastrointestinal disorders. In our opinion, L. reuteri meets all the requirements to be considered a safe, well-tolerated, and efficacious probiotic that is able to contribute to the beneficial effects on gut-human health, preventing and treating many gastrointestinal symptoms, and speeding up the recovery and discharge of patients accessing the emergency department.<\/jats:p>","DOI":"10.3390\/medicina57070643","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T11:28:41Z","timestamp":1624447721000},"page":"643","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Lactobacillus Reuteri DSM 17938 (Limosilactobacillus reuteri) in Diarrhea and Constipation: Two Sides of the Same Coin?"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2820-7180","authenticated-orcid":false,"given":"Angela","family":"Saviano","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8507-855X","authenticated-orcid":false,"given":"Mattia","family":"Brigida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Universit\u00e0 Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Migneco","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6580-1122","authenticated-orcid":false,"given":"Gayani","family":"Gunawardena","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Zanza","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Emergency Medicine-Fondazione Nuovo Ospedale Alba-Bra, Michele and Pietro Ferrero Hospital, 12060 Verduno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-7880","authenticated-orcid":false,"given":"Marcello","family":"Candelli","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Franceschi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Ojetti","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3389\/fmicb.2018.00757","article-title":"Role of Lactobacillus reuteri in Human Health and Diseases","volume":"9","author":"Mu","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kubota, M., Ito, K., Tomimoto, K., Kanazaki, M., Tsukiyama, K., Kubota, A., Kuroki, H., Fujita, M., and Vandenplas, Y. (2020). Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients, 12.","DOI":"10.3390\/nu12010225"},{"key":"ref_3","first-page":"1702","article-title":"Effect of Lactobacillus reuteri (DSM 17938) on methane production in patients affected by functional constipation: A retrospective study","volume":"21","author":"Ojetti","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1128\/AEM.70.2.1176-1181.2004","article-title":"Colonization and Immunomodulation by Lactobacillus reuteri ATCC 55730 in the Human Gastrointestinal Tract","volume":"70","author":"Valeur","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1128\/AEM.00991-08","article-title":"Removal of antibiotic resistance gene-carrying plasmids from Lactobacillus reuteri ATCC 55730 and characterization of the resulting daughter strain, L. reuteri DSM 17938","volume":"74","author":"Rosander","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1093\/femsre\/fux030","article-title":"Lifestyles in transition: Evolution and natural history of the genus Lactobacillus","volume":"41","author":"Duar","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40104-015-0014-3","article-title":"Study and use of the probiotic Lactobacillus reuteri in pigs: A review","volume":"6","author":"Hou","year":"2015","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/5584_2018_321","article-title":"Probiotics in Functional Gastrointestinal Disorders","volume":"1125","author":"Hojsak","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Jones, S.E., and Versalovic, J. (2009). Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors. BMC Microbiol., 9.","DOI":"10.1186\/1471-2180-9-35"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1016\/j.clnu.2020.04.019","article-title":"Lactobacillus reuteri DSM 17938 is effective in the treatment of functional abdominal pain in children: Results of the double-blind randomized study","volume":"39","author":"Sila","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1128\/MMBR.00017-08","article-title":"Genes and Molecules of Lactobacilli Supporting Probiotic Action","volume":"72","author":"Lebeer","year":"2008","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s11739-013-1013-z","article-title":"Lactobacillus reuteri in the treatment of Helicobacter pylori infection","volume":"9","author":"Dore","year":"2014","journal-title":"Intern. Emerg. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e12659","DOI":"10.1111\/hel.12659","article-title":"Twice-a-day PPI, tetracycline, metronidazole quadruple therapy with Pylera\u00ae or Lactobacillus reuteri for treatment na\u00efve or for retreatment of Helicobacter pylori. Two randomized pilot studies","volume":"24","author":"Dore","year":"2019","journal-title":"Helicobacter"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jpeds.2014.09.020","article-title":"Probiotics for Infantile Colic: A Randomized, Double-Blind, Placebo-Controlled Trial Investigating Lactobacillus reuteri DSM 17938","volume":"166","author":"Chau","year":"2015","journal-title":"J. Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"West, C.L., Stanisz, A.M., Mao, Y.-K., Champagne-Jorgensen, K., Bienenstock, J., and Kunze, W.A. (2020). Microvesicles from Lactobacillus reuteri (DSM-17938) completely reproduce modulation of gut motility by bacteria in mice. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0225481"},{"key":"ref_16","first-page":"339","article-title":"Use of probiotics in the treatment of functional abdominal pain in children\u2014Systematic review and meta-analysis","volume":"180","author":"Niseteo","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/MPG.0000000000002751","article-title":"Use of Probiotics for the Management of Acute Gastroenteritis in Children: An Update","volume":"71","author":"Szajewska","year":"2020","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2036.2012.05180.x","article-title":"Randomised clinical trial: Lactobacillus reuteri DSM 17938 vs. placebo in children with acute diarrhoea\u2014A double-blind study","volume":"36","author":"Francavilla","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jped.2014.10.009","article-title":"Lactobacillus reuteri DSM 17938 shortens acute infectious diarrhea in a pediatric outpatient setting","volume":"91","author":"Dinleyici","year":"2015","journal-title":"J. Pediatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1097\/MCG.0b013e3182257e98","article-title":"Probiotics for Prevention and Treatment of Diarrhea","volume":"45","author":"Guandalini","year":"2011","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Amoroso, C., Perillo, F., Strati, F., Fantini, M., Caprioli, F., and Facciotti, F. (2020). The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation. Cells, 9.","DOI":"10.3390\/cells9051234"},{"key":"ref_22","first-page":"170","article-title":"Probiotics for Gastrointestinal Conditions: A Summary of the Evidence","volume":"96","author":"Wilkins","year":"2017","journal-title":"Am. Fam. Phys."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/00006454-199712000-00002","article-title":"Bacteriotherapy with Lactobacillus reuteri in rotavirus gastro-enteritis","volume":"16","author":"Shornikova","year":"1997","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_24","first-page":"399","article-title":"Lactobacillus reuteri as a Therapeutic Agent in Acute Diarrhea in Young Children","volume":"24","author":"Shornikova","year":"1997","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.1111\/apa.12617","article-title":"Lactobacillus reuteri DSM 17938 effectively reduces the duration of acute diarrhoea in hospitalised children","volume":"103","author":"Dinleyici","year":"2014","journal-title":"Acta Paediatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/apt.13590","article-title":"Systematic review with meta-analysis: Lactobacillus reuteri DSM 17938 for diarrhoeal diseases in children","volume":"43","author":"Szajewska","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/INF.0000000000002355","article-title":"Lack of Efficacy of Lactobacillus reuteri DSM 17938 for the Treatment of Acute Gastroenteritis: A Randomized Controlled Trial","volume":"38","author":"Szajewska","year":"2019","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_28","first-page":"3097","article-title":"Effect of Lactobacillus reuteri LRE02-Lactobacillus rhamnosus LR04 combination and gastrointestinal functional disorders in an Emergency Department pediatric population","volume":"25","author":"Margiotta","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Patro-Go\u0142\u0105b, B., and Szajewska, H. (2019). Systematic Review with Meta-Analysis: Lactobacillus reuteri DSM 17938 for Treating Acute Gas-troenteritis in Children. An Update. Nutrients, 11.","DOI":"10.3390\/nu11112762"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1574-6941.2007.00412.x","article-title":"Glycerol induces reuterin production and decreases Escherichia coli population in an in vitro model of colonic fermentation with immobilized human feces","volume":"63","author":"Cleusix","year":"2008","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"740381","DOI":"10.1155\/2012\/740381","article-title":"Impact of Lactobacillus reuteri Supple-mentation on Anti-Helicobacter pylori Levofloxacin-Based Second-Line Therapy","volume":"2012","author":"Ojetti","year":"2012","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.gtc.2015.05.005","article-title":"Is There a Role for Probiotics in Helicobacter pylori Therapy?","volume":"44","author":"Dore","year":"2015","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/MCG.0b013e318266f6cf","article-title":"Meta-analysis of the efficacy and safety of Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation in Helicobacter pylori eradication therapy","volume":"47","author":"Wang","year":"2013","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/hel.12237","article-title":"Emerging Role of Probiotics in the Management of Helicobacter pylori Infection: Histopathologic Perspectives","volume":"21","author":"Emara","year":"2016","journal-title":"Helicobacter"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/1756283X13503514","article-title":"Lactobacillus reuteri in management of Helicobacter pylori infection in dyspeptic patients: A double-blind placebo-controlled randomized clinical trial","volume":"7","author":"Emara","year":"2014","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Buckley, M., Lacey, S., Doolan, A., Goodbody, E., and Seamans, K. (2018). The effect of Lactobacillus reuteri supplementation in Helicobacter pylori infection: A placebo-controlled, single-blind study. BMC Nutr., 4.","DOI":"10.1186\/s40795-018-0257-4"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.15403\/jgld.2014.1121.234.elr","article-title":"The Effect of Lactobacillus reuteri Supplementation in Adults with Chronic Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial*","volume":"23","author":"Ojetti","year":"2014","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jpeds.2010.04.066","article-title":"Lactobacillus reuteri (DSM 17938) in Infants with Functional Chronic Constipation: A Double-Blind, Randomized, Placebo-Controlled Study","volume":"157","author":"Coccorullo","year":"2010","journal-title":"J. Pediatr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1001\/jamapediatrics.2013.4367","article-title":"Prophylactic Use of a Probiotic in the Prevention of Colic, Regurgitation, and Functional Constipation","volume":"168","author":"Indrio","year":"2014","journal-title":"JAMA Pediatr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/MPG.0000000000002134","article-title":"Lack of Benefit of Lactobacillus reuteri DSM 17938 as an Addition to the Treatment of Functional Constipation","volume":"67","author":"Sila","year":"2018","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e2018123","DOI":"10.1590\/1984-0462\/2020\/38\/2018123","article-title":"Gut microbiota and the use of probiotics in constipation in children and adolescents: Systematic review","volume":"38","author":"Gomes","year":"2020","journal-title":"Rev. Paul Pediatr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3920\/BM2018.0050","article-title":"Effects of long-term administration of Lactobacillus reuteri DSM-17938 on circulating levels of 5-HT and BDNF in adults with functional constipation","volume":"10","author":"Riezzo","year":"2019","journal-title":"Benef. Microbes"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1017\/S0029665119000934","article-title":"Probiotics and constipation: Mechanisms of action, evidence for effectiveness and utilisation by patients and healthcare professionals","volume":"79","author":"Dimidi","year":"2019","journal-title":"Proc. Nutr. Soc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3945\/an.116.014407","article-title":"Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation","volume":"8","author":"Dimidi","year":"2017","journal-title":"Adv. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1097\/MCG.0000000000001054","article-title":"Effectiveness of Probiotics in Children with Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review","volume":"52","author":"Wegh","year":"2018","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41564-020-0721-1","article-title":"Moving from probiotics to precision probiotics","volume":"5","author":"Veiga","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e01124-20","DOI":"10.1128\/mSystems.01124-20","article-title":"Nutraceuticals Induced Changes in the Broiler Gastrointestinal Tract Microbiota","volume":"6","author":"Tolnai","year":"2021","journal-title":"mSystems"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sanders, M.E. (2016). Probiotics and microbiota composition. BMC Med., 14.","DOI":"10.1186\/s12916-016-0629-z"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41575-019-0173-3","article-title":"Probiotics and prebiotics in intestinal health and disease: From biology to the clinic","volume":"16","author":"Sanders","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"481651","DOI":"10.5402\/2013\/481651","article-title":"Health Benefits of Probiotics: A Review","volume":"2013","author":"Kechagia","year":"2013","journal-title":"ISRN Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s15010-019-01351-0","article-title":"Probiotics in health and disease: Fooling Mother Nature?","volume":"47","author":"Abid","year":"2019","journal-title":"Infection"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3389\/fmicb.2020.01662","article-title":"Criteria to Qualify Microorganisms as \u201cProbiotic\u201d in Foods and Dietary Supplements","volume":"11","author":"Binda","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1136\/gutjnl-2012-302504","article-title":"An update on the use and investigation of probiotics in health and disease","volume":"62","author":"Sanders","year":"2013","journal-title":"Gut"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Li, L., Fang, Z., Liu, X., Hu, W., Lu, W., Lee, Y.-K., Zhao, J., Zhang, H., and Chen, W. (2020). Lactobacillus reuteri attenuated allergic inflammation induced by HDM in the mouse and modulated gut microbes. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0231865"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/NMC.0000000000000691","article-title":"Probiotics for the Management of Infantile Colic: A Systematic Review","volume":"46","author":"Simonson","year":"2021","journal-title":"MCN Am. J. Matern. Child. Nurs."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41575-020-00390-5","article-title":"The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods","volume":"18","author":"Marco","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1099\/mic.0.035642-0","article-title":"The antimicrobial compound reuterin (3-hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groups","volume":"156","author":"Schaefer","year":"2010","journal-title":"Microbiology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"103754","DOI":"10.1016\/j.micpath.2019.103754","article-title":"Lactobacillus reuteri protects mice against Salmonella typhimurium challenge by activating macrophages to produce nitric oxide","volume":"137","author":"Jiang","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Asare, P.T., Zurfluh, K., Greppi, A., Lynch, D., Schwab, C., Stephan, R., and Lacroix, C. (2020). Reuterin Demonstrates Potent Antimicrobial Activity Against a Broad Panel of Human and Poultry Meat Campylobacter spp. Isolates. Microorganisms, 8.","DOI":"10.3390\/microorganisms8010078"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/7\/643\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:21:47Z","timestamp":1760163707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/7\/643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,23]]},"references-count":60,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["medicina57070643"],"URL":"https:\/\/doi.org\/10.3390\/medicina57070643","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,23]]}}}