{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:06:01Z","timestamp":1793675161080,"version":"4.5.1"},"reference-count":48,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Myelomeningocele is the most severe form of spina bifida, a congenital neural tube defect arising from an incomplete neural tube closure during early development with damage worsening with advancing gestational age. The Management of Myelomeningocele Study (MOMS) Trial proved that surgery performed before 26 weeks of gestation significantly improved the prognosis, significantly changing treatment paradigms. This article aims to provide a review of the changes and updates in spina bifida repair over the 10-year period following the MOMS Trial. Material and methods: We performed a systematic review in the PubMed and Cochrane databases as well as a hand-search of high-impact journals using the reference list of all identified articles, searching for randomized controlled trials and observational studies. Results: We identified 27 articles published between 2011 and 2021 that fulfilled the inclusion criteria and review them in the present study. Conclusions: With growing experience and with the improvement of prenatal open and fetoscopic techniques, the outcome of SB-associated conditions could be improved and the risks to both the mother and the fetus reduced. A continuous follow-up of the treated infants and further randomized trials are essential to study the complications and advantages or disadvantages of any given treatment strategy.<\/jats:p>","DOI":"10.3390\/medicina57070707","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T21:56:37Z","timestamp":1626126997000},"page":"707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Myelomeningocele Surgery over the 10 Years Following the MOMS Trial: A Systematic Review of Outcomes in Prenatal versus Postnatal Surgical Repair"],"prefix":"10.3390","volume":"57","author":[{"given":"Francesca Gabriela","family":"Paslaru","sequence":"first","affiliation":[{"name":"Neurosurgical Department, \u201cBagdasar-Arseni\u201d Clinical Emergency Hospital, 041915 Bucharest, Romania"},{"name":"Neurosurgery Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Maria","family":"Panaitescu","sequence":"additional","affiliation":[{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"},{"name":"Obstetrics and Gynecology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Iancu","sequence":"additional","affiliation":[{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"},{"name":"Obstetrics and Gynecology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Veduta","sequence":"additional","affiliation":[{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8425-6307","authenticated-orcid":false,"given":"Nicolae","family":"Gica","sequence":"additional","affiliation":[{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"},{"name":"Obstetrics and Gynecology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru Catalin","family":"Paslaru","sequence":"additional","affiliation":[{"name":"Physiology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamaria","family":"Gheorghiu","sequence":"additional","affiliation":[{"name":"Neurosurgical Department, \u201cBagdasar-Arseni\u201d Clinical Emergency Hospital, 041915 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheorghe","family":"Peltecu","sequence":"additional","affiliation":[{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"},{"name":"Obstetrics and Gynecology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Mircea","family":"Gorgan","sequence":"additional","affiliation":[{"name":"Neurosurgical Department, \u201cBagdasar-Arseni\u201d Clinical Emergency Hospital, 041915 Bucharest, Romania"},{"name":"Neurosurgery Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.clp.2012.04.003","article-title":"Fetal Surgery for Myelomeningocele","volume":"39","author":"Saadai","year":"2012","journal-title":"Clin. 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