{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:30:07Z","timestamp":1791495007293,"version":"4.3.4"},"reference-count":51,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>By participating in both the recruitment and activation of T lymphocytes, macrophages and neutrophils at the site of psoriatic inflammation, chemokines play an important role in the pathogenesis of psoriasis and, crucially, may be one indicator of the response to the systemic treatment of the disease. As a result of their major involvement in both physiological and pathological processes, both chemokines and their receptors have been identified as possible therapeutic targets. Due to their presence in the inflammatory process, they play a role in the pathogenesis of diseases that often coexist with psoriasis, such as atherosclerosis and psoriatic arthritis. Chemokines, cytokines and adhesion molecules may be biological markers of disease severity in psoriasis. However, the mechanism of inflammation in psoriasis is too complex to select only one marker to monitor the disease process and improvement after treatment. The aim of this review was to summarize previous reports on the role of chemokines in the pathogenesis of psoriasis, its treatment and comorbidities.<\/jats:p>","DOI":"10.3390\/medicina57080754","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T04:19:30Z","timestamp":1627273170000},"page":"754","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The Role of Chemokines in Psoriasis\u2014An Overview"],"prefix":"10.3390","volume":"57","author":[{"given":"Natalia","family":"Zdanowska","sequence":"first","affiliation":[{"name":"Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-229 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4177-8404","authenticated-orcid":false,"given":"Marta","family":"Kasprowicz-Furma\u0144czyk","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-229 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Placek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-229 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-0438","authenticated-orcid":false,"given":"Agnieszka","family":"Owczarczyk-Saczonek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-229 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S1995-7645(14)60098-5","article-title":"Effect of pharmacological intervention on MIP-1\u03b1, MIP-1\u03b2 and MCP-1 expression in patients with psoriasis vulgaris","volume":"7","author":"Dai","year":"2014","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jdermsci.2011.11.007","article-title":"Chemokine receptors in the pathogenesis and therapy of psoriasis","volume":"65","author":"Mabuchi","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1590\/S1679-45082015RB3438","article-title":"Chemokines and immunity","volume":"13","author":"Palomino","year":"2015","journal-title":"Einstein"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jaci.2017.07.004","article-title":"Psoriasis pathogenesis and the development of novel targeted immune therapies","volume":"140","author":"Hawkes","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1744-9987.2012.01108.x","article-title":"Adsorptive Depletion of CD14+CD16+Proinflammatory Monocyte Phenotype in Patients with Generalized Pustular Psoriasis: Clinical Efficacy and Effects on Cytokines","volume":"16","author":"Fujisawa","year":"2012","journal-title":"Ther. Apher. Dial."},{"key":"ref_7","first-page":"486","article-title":"Th17 gene expression in psoriatic arthritis synovial fluid and peripheral blood compared to osteoarthritis and cutaneous psoriasis","volume":"36","author":"Abji","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jocd.12994","article-title":"Evaluation of the expression of the stromal cell-derived factor-1 alpha (CXCL 12) in psoriatic patients after treatment with Methotrexate","volume":"19","author":"Abdelaal","year":"2019","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"119034","DOI":"10.1016\/j.lfs.2021.119034","article-title":"Role of CCL2\/CCR2 axis in the immunopathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches","volume":"269","author":"Moadab","year":"2021","journal-title":"Life Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/ATVBAHA.118.312246","article-title":"Inflammasome Signaling and Impaired Vascular Health in Psoriasis","volume":"39","author":"Garshick","year":"2019","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kouassi, K.T., Gunasekar, P., Agrawal, D.K., and Jadhav, G.P. (2018). TREM-1; Is It a Pivotal Target for Cardiovascular Diseases?. J. Cardiovasc. Dev. Dis., 5.","DOI":"10.20944\/preprints201809.0040.v1"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1111\/j.1538-7836.2005.01420.x","article-title":"PAI-1 and atherothrombosis","volume":"3","author":"Vaughan","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Barale, C., and Russo, I. (2020). Influence of Cardiometabolic Risk Factors on Platelet Function. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020623"},{"key":"ref_14","first-page":"1","article-title":"Obesity-associated T-cell and macrophage activation improve partly after a lifestyle intervention","volume":"44","author":"Wester","year":"2020","journal-title":"Int. J. Obes."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2230.2011.04295.x","article-title":"Expression of CCL1 and CCL18 in atopic dermatitis and psoriasis","volume":"37","author":"Kim","year":"2012","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Canavese, M., Altruda, F., and Silengo, L. (2010). Therapeutic Efficacy and Immunological Response of CCL5 Antagonists in Models of Contact Skin Reaction. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0008725"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-09207-z","article-title":"The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins","volume":"7","author":"Brunner","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.advms.2015.07.011","article-title":"CXCL10 in psoriasis","volume":"60","author":"Ferrari","year":"2015","journal-title":"Adv. Med Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/bjd.17334","article-title":"Association of CCL2 with systemic inflammation in Schnitzler syndrome","volume":"180","author":"Krause","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Dembic, Z. (2015). Cytokines of the Immune System. The Cytokines of the Immune System, Academic Press.","DOI":"10.1016\/B978-0-12-419998-9.00006-7"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.cyto.2017.12.010","article-title":"A brief look at the role of monocyte chemoattractant protein-1 (CCL2) in the pathophysiology of psoriasis","volume":"110","author":"Behfar","year":"2018","journal-title":"Cytokine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"12137","DOI":"10.4238\/2015.October.9.1","article-title":"Effect of NB-UVB on levels of MCP-1 and CCR6 mRNA in patients with psoriasis vulgaris","volume":"14","author":"Gao","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.14712\/18059694.2016.100","article-title":"CC and CXC Chemokines Patterns in Psoriasis Determined by Protein Array Method Were Influenced by Goeckerman\u2019s Therapy","volume":"52","author":"Pohl","year":"2009","journal-title":"Acta Med. (Hradec Kralove)"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/09546634.2013.782091","article-title":"MCP-1 in psoriatic patients: Effect of biological therapy","volume":"25","author":"Lembo","year":"2013","journal-title":"J. Dermatol. Treat."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.5114\/pdia.2014.40920","article-title":"Chemokines and cytokines network in the pathogenesis of the inflammatory skin diseases: Atopic dermatitis, psoriasis and skin mastocytosis","volume":"2","author":"Nedoszytko","year":"2014","journal-title":"Postep. Dermatol. Alergol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00403-007-0764-7","article-title":"Expression of the chemokine receptor CCR5 in psoriasis and results of a randomized placebo controlled trial with a CCR5 inhibitor","volume":"299","author":"Teunissen","year":"2007","journal-title":"Arch. Dermatol. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1684\/ejd.2012.1730","article-title":"Reduction of RANTES expression in lesional psoriatic skin after narrow band ultraviolet therapy: A possible marker of therapeutic efficacy","volume":"22","author":"Rateb","year":"2012","journal-title":"Eur. J. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.0906-6705.2004.00205.x","article-title":"Biology of tumor necrosis factor-alpha- implications for psoriasis","volume":"13","author":"Schottelius","year":"2004","journal-title":"Exp. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5603\/FHC.2012.0010","article-title":"Evaluation of CD40, its ligand CD40L and Bcl-2 in psoriatic patients","volume":"50","author":"Flisiak","year":"2012","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/cei.13451","article-title":"Serum sCD40L levels are increased in patients with psoriatic arthritis and are associated with clinical response to apremilast","volume":"201","author":"Venerito","year":"2020","journal-title":"Clin. Exp. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e4328","DOI":"10.1097\/MD.0000000000004328","article-title":"Elevated expression of growth-regulated oncogene-alpha in tumor and stromal cells predicts unfavorable prognosis in pancreatic cancer","volume":"95","author":"Lian","year":"2016","journal-title":"Medicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100027","DOI":"10.1016\/j.xjidi.2021.100027","article-title":"Bath-PUVA therapy suppresses keratinocyte-derived chemokines in pathoge-netically relevant cells","volume":"1","author":"Kanayama","year":"2021","journal-title":"JID Innov."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1046\/j.1365-2133.2001.04220.x","article-title":"The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells","volume":"144","author":"Stoof","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/bjd.18940","article-title":"Declining levels of serum chemokine (C-X-C motif) ligand 10 over time are associated with new onset of psoriatic arthritis in patients with psoriasis: A new biomarker?","volume":"183","author":"Abji","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.autrev.2013.10.010","article-title":"Chemokine (C\u2013X\u2013C motif) ligand (CXCL)10 in autoimmune diseases","volume":"13","author":"Antonelli","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.4049\/jimmunol.175.4.2721","article-title":"TNF Inhibition Rapidly Down-Regulates Multiple Proinflammatory Pathways in Psoriasis Plaques","volume":"175","author":"Gottlieb","year":"2005","journal-title":"J. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1476-5381.2009.00559.x","article-title":"Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis","volume":"159","author":"Schafer","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1189\/jlb.1103570","article-title":"I-TAC\/CXCL11 is a natural antagonist for CCR","volume":"76","author":"Petkovic","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/1096-9896(200108)194:4<397::AID-PATH899>3.0.CO;2-S","article-title":"Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation","volume":"194","author":"Flier","year":"2001","journal-title":"J. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jaad.2020.04.138","article-title":"Cross-sectional study of blood biomarkers of patients with moderate to severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation","volume":"84","author":"Glickman","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1189\/jlb.0909602","article-title":"The multiple faces of CXCL12 (SDF-1\u03b1) in the regulation of immunity during health and disease","volume":"88","author":"Karin","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zgraggen, S., Huggenberger, R., Kerl, K., and Detmar, M. (2014). An Important Role of the SDF-1\/CXCR4 Axis in Chronic Skin Inflammation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0093665"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jcp.22783","article-title":"PAI-1 in tissue fibrosis","volume":"227","author":"Ghosh","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10238-019-00595-2","article-title":"Cell adhesion molecules, plasminogen activator inhibitor type 1, and metabolic syndrome in patients with psoriasis","volume":"20","author":"Teixeira","year":"2020","journal-title":"Clin. Exp. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.jaad.2013.12.044","article-title":"Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis","volume":"70","author":"Sigurdardottir","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/jid.2013.68","article-title":"TREM-1 as a potential therapeutic target in psoriasis","volume":"133","author":"Hyder","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1007\/s13238-015-0198-5","article-title":"Dermal fibroblast expression of stromal cell-derived factor-1 (SDF-1) promotes epidermal keratinocyte proliferation in normal and diseased skin","volume":"6","author":"Quan","year":"2015","journal-title":"Protein Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/art.39800","article-title":"Brief Report: CXCL10 Is a Possible Biomarker for the Development of Psoriatic Arthritis Among Patients with Psoriasis","volume":"68","author":"Abji","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Shih, C.-M., Hsieh, C.-K., Huang, C.-Y., Huang, C.-Y., Wang, K.-H., Fong, T.-H., Trang, N.T.T., Liu, K.-T., and Lee, A.-W. (2020). Lycopene Inhibit IMQ-Induced Psoriasis-Like Inflammation by Inhibiting ICAM-1 Production in Mice. Polymers, 12.","DOI":"10.3390\/polym12071521"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/ijd.13883","article-title":"Evaluation of ICAM-1 expression and vascular changes in the skin of patients with plaque, pustular, and erythrodermic psoriasis","volume":"57","author":"Bressan","year":"2018","journal-title":"Int. J. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5603\/FHC.2012.0025","article-title":"Biochemical markers of psoriasis as a metabolic disease","volume":"50","author":"Gerkowicz","year":"2012","journal-title":"Folia Histochem. Cytobiol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/8\/754\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:34:53Z","timestamp":1760164493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/8\/754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,26]]},"references-count":51,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["medicina57080754"],"URL":"https:\/\/doi.org\/10.3390\/medicina57080754","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,26]]}}}