{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:20:41Z","timestamp":1784992841646,"version":"3.55.0"},"reference-count":90,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The microbiota is the set of commensal microorganisms, residing in the organism, helping proper functioning of organs and systems. The role that the microbiota plays in maintaining the health of vertebrates is widely accepted, particularly in the gastrointestinal system, where it is fundamental for immunity, development, and conversion of nutrients. Dysbiosis is an alteration of the microbiota which refers to a disturbed balance, which can cause a number of pathologies. Probiotics have proven to be effective in modulating the microbiota of the gastrointestinal system and, therefore, in promoting the health of the individual. In particular, Lactobacilli are a group of Gram-positive bacteria, which are able to produce lactic acid through glucose metabolism. They are present in different microenvironments, ranging from the vagina, to the mouth, to different tracts of the small intestine. In the present review, we will discuss the use of Limosilactobacillus in human health in general and more specifically in diverticulitis. In particular we analyze the role of Limosilactobacillus reuteri and its anti-inflammatory action. For this review, articles were identified using the electronic PubMed database through a comprehensive search, conducted by combining key terms such as \u201cdiverticulitis\u201d, \u201cLimosilactobacillus reuteri\u201d, \u201chuman health and disease\u201d, \u201cprobiotics\u201d. We selected all the articles published in the last 10 years and screened 1017 papers. Articles referenced in the screened papers were evaluated if considered interesting for our topic. Probiotics have proven to be effective in modulating the microbiota of the gastrointestinal system and, therefore, in promoting the health of the individual. The importance of probiotics in treating diverticular disease and acute diverticulitis can be further understood if taking into consideration some pathophysiological aspects, associated to the microbiota. L. reuteri plays an important role in human health and disease. The effectiveness of L. reuteri in stimulating a correct bowl motility partly explains its effectiveness in treating diverticulitis. The most important action of L. reuteri is probably its immunomodulating activity. Levels of IL-6, IL-8, and Tumor necrosis factor (TNF-alpha) are reduced after supplementation with different strands of Lactobacilli, while T-regulatory cells increase in number and activity. Anyway, new mechanisms of action of probiotics come to light from the many investigations currently taking place in numerous centres around the world and to improve how exactly probiotic administration could make the difference in the management of diverticular disease and acute diverticulitis.<\/jats:p>","DOI":"10.3390\/medicina57080802","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T04:33:29Z","timestamp":1628138009000},"page":"802","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Microbiota and Probiotics: The Role of Limosilactobacillus Reuteri in Diverticulitis"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5703-8737","authenticated-orcid":false,"given":"Andrea","family":"Piccioni","sequence":"first","affiliation":[{"name":"Emergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Franza","sequence":"additional","affiliation":[{"name":"Emergency Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Vaccaro","sequence":"additional","affiliation":[{"name":"Emergency Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2820-7180","authenticated-orcid":false,"given":"Angela","family":"Saviano","sequence":"additional","affiliation":[{"name":"Emergency Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Zanza","sequence":"additional","affiliation":[{"name":"Emergency Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-7880","authenticated-orcid":false,"given":"Marcello","family":"Candelli","sequence":"additional","affiliation":[{"name":"Emergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6709-2531","authenticated-orcid":false,"given":"Marcello","family":"Covino","sequence":"additional","affiliation":[{"name":"Emergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Franceschi","sequence":"additional","affiliation":[{"name":"Emergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, Italy"},{"name":"Emergency Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Ojetti","sequence":"additional","affiliation":[{"name":"Emergency Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.immuni.2017.04.008","article-title":"Homeostatic Immunity and the Microbiota","volume":"46","author":"Belkaid","year":"2017","journal-title":"Immunity"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3389\/fmicb.2018.00757","article-title":"Role of Lactobacillus reuteri in Human Health and Diseases","volume":"9","author":"Mu","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.4014\/jmb.1906.06064","article-title":"Role of Probiotics in Human Gut Microbiome-Associated Diseases","volume":"29","author":"Kim","year":"2019","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_4","first-page":"512","article-title":"Selective Manipulation of the Gut Microbiota Improves Immune Status in Vertebrates","volume":"6","author":"Bossier","year":"2015","journal-title":"Front. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1093\/cid\/civ072","article-title":"Lactobacillus Species: Taxonomic Complexity and Controversial Susceptibilities","volume":"60","author":"Goldstein","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fmed.2018.00181","article-title":"The Vaginal Microenvironment: The Physiologic Role of Lactobacilli","volume":"5","author":"Amabebe","year":"2018","journal-title":"Front. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"110s","DOI":"10.1177\/0022034515576052","article-title":"Oral Lactobacilli and Dental Caries: A Model for Niche Adaptation in Humans","volume":"94","author":"Caufield","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.3389\/fimmu.2018.02240","article-title":"Immunological Tolerance and Function: Associations Between Intestinal Bacteria, Probiotics, Prebiotics, and Phages","volume":"9","author":"Vitetta","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"927268","DOI":"10.1155\/2014\/927268","article-title":"Probiotic Potential of Lactobacillus Strains with Antimicrobial Activity against Some Human Pathogenic Strains","volume":"2014","author":"Shokryazdan","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fphys.2015.00081","article-title":"Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health","volume":"6","author":"Petrova","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.3390\/ijerph110504745","article-title":"Microorganisms with claimed probiotic properties: An overview of recent literature","volume":"11","author":"Fijan","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4014\/jmb.1806.06004","article-title":"Combined Lowering Effects of Rosuvastatin and L. acidophilus on Cholesterol Levels in Rat","volume":"29","author":"Wang","year":"2019","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2174\/1573399815666190206162143","article-title":"The Gut Microbiome, Lactobacillus acidophilus; Relation with Type 2 Diabetes Mellitus","volume":"15","author":"Halawa","year":"2019","journal-title":"Curr. Diabetes Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.14715\/cmb\/2017.63.9.21","article-title":"Lactobacillus acidophilus versus placebo in the symptomatic treatment of irritable bowel syndrome: The LAPIBSS randomized trial","volume":"63","author":"Sadrin","year":"2017","journal-title":"Cell. Mol. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.fsi.2014.12.003","article-title":"The effects of Lactobacillus acidophilus as feed supplement on skin mucosal immune parameters, intestinal microbiota, stress resistance and growth performance of black swordtail (Xiphophorus helleri)","volume":"42","author":"Hoseinifar","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1097\/MCG.0b013e3182257e98","article-title":"Probiotics for prevention and treatment of diarrhea","volume":"45","author":"Guandalini","year":"2011","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10529-020-02814-3","article-title":"Protective effect of Lactobacillus casei HY2782 against particulate matter toxicity in human intestinal CCD-18Co cells and Caenorhabditis elegans","volume":"42","author":"Kim","year":"2020","journal-title":"Biotechnol. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ibd.20736","article-title":"Lactobacillus casei downregulates commensals\u2019 inflammatory signals in Crohn\u2019s disease mucosa","volume":"15","author":"Llopis","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3389\/fmicb.2019.00324","article-title":"Lactobacillus casei Strain Shirota Alleviates Constipation in Adults by Increasing the Pipecolinic Acid Level in the Gut","volume":"10","author":"Ou","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Shin, M.Y., Yong, C.C., and Oh, S. (2020). Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis. Foods, 9.","DOI":"10.3390\/foods9070864"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.3389\/fmicb.2018.02425","article-title":"Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-\u03baB Signaling Cascades","volume":"9","author":"Jiang","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/19490976.2019.1589281","article-title":"Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota","volume":"10","author":"Jang","year":"2019","journal-title":"Gut Microbes"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3920\/BM2019.0180","article-title":"Effects of Lactobacillus fermentum CECT5716 Lc40 on infant growth and health: A randomised clinical trial in nursing women","volume":"11","author":"Hurtado","year":"2020","journal-title":"Benef. Microbes"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1475-2891-10-30","article-title":"Lactobacillus fermentum (PCC\u00ae) supplementation and gastrointestinal and respiratory-tract illness symptoms: A randomised control trial in athletes","volume":"10","author":"West","year":"2011","journal-title":"Nutr. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"583070","DOI":"10.3389\/fmicb.2020.583070","article-title":"Lactobacillus delbrueckii subsp. bulgaricus KLDS 1.0207 Exerts Antimicrobial and Cytotoxic Effects in vitro and Improves Blood Biochemical Parameters In Vivo against Notable Foodborne Pathogens","volume":"11","author":"Evivie","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/00016357.2019.1609697","article-title":"Effect of ingesting yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on influenza virus-bound salivary IgA in elderly residents of nursing homes: A randomized controlled trial","volume":"77","author":"Yamamoto","year":"2019","journal-title":"Acta Odontol. Scand."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Mohtashami, M., Mohamadi, M., Azimi-Nezhad, M., Saeidi, J., Nia, F.F., and Ghasemi, A. (2020). Lactobacillus bulgaricus and Lactobacillus plantarum improve diabetic wound healing through modulating inflammatory factors. Biotechnol. Appl. Biochem.","DOI":"10.1002\/bab.2064"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.phrs.2017.08.001","article-title":"Probiotics and antibiotic-associated diarrhea in children: A review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment","volume":"128","author":"Mantegazza","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/apt.13404","article-title":"Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults","volume":"42","author":"Szajewska","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.15403\/jgld.2014.1121.234.elr","article-title":"The effect of Lactobacillus reuteri supplementation in adults with chronic functional constipation: A randomized, double-blind, placebo-controlled trial","volume":"23","author":"Ojetti","year":"2014","journal-title":"J. Gastrointest. Liver Dis. JGLD"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/dom.12861","article-title":"Metabolic effects of Lactobacillus reuteri DSM 17938 in people with type 2 diabetes: A randomized controlled trial","volume":"19","author":"Mobini","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00384-019-03295-1","article-title":"Supplementation with Lactobacillus reuteri ATCC PTA 4659 in patients affected by acute uncomplicated diverticulitis: A randomized double-blind placebo controlled trial","volume":"34","author":"Petruzziello","year":"2019","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.resmic.2010.03.001","article-title":"Importance of lactobacilli in food and feed biotechnology","volume":"161","author":"Giraffa","year":"2010","journal-title":"Res. Microbiol."},{"key":"ref_34","first-page":"27799","article-title":"Changes in vaginal microbiota following antimicrobial and probiotic therapy","volume":"26","author":"Macklaim","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Romani Vestman, N., Chen, T., Lif Holgerson, P., \u00d6hman, C., and Johansson, I. (2015). Oral Microbiota Shift after 12-Week Supplementation with Lactobacillus reuteri DSM 17938 and PTA 5289; A Randomized Control Trial. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125812"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1128\/AAC.33.5.674","article-title":"Chemical characterization of an antimicrobial substance produced by Lactobacillus reuteri","volume":"33","author":"Talarico","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1128\/AEM.69.2.1305-1307.2003","article-title":"Studies on the mode of action of reutericyclin","volume":"69","author":"Vogel","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Yang, F., Wang, A., Zeng, X., Hou, C., Liu, H., and Qiao, S. (2015). Lactobacillus reuteri I5007 modulates tight junction protein expression in IPEC-J2 cells with LPS stimulation and in newborn piglets under normal conditions. BMC Microbiol., 15.","DOI":"10.1186\/s12866-015-0372-1"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Thomas, C.M., Hong, T., van Pijkeren, J.P., Hemarajata, P., Trinh, D.V., Hu, W., Britton, R.A., Kalkum, M., and Versalovic, J. (2012). Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031951"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Candelli, M., Franza, L., Pignataro, G., Ojetti, V., Covino, M., Piccioni, A., Gasbarrini, A., and Franceschi, F. (2021). Interaction between Lipopolysaccharide and Gut Microbiota in Inflammatory Bowel Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126242"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Salas-Jara, M.J., Ilabaca, A., Vega, M., and Garc\u00eda, A. (2016). Biofilm Forming Lactobacillus: New Challenges for the Development of Probiotics. Microorganisms, 4.","DOI":"10.3390\/microorganisms4030035"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.carbpol.2015.12.037","article-title":"Exopolysaccharides of Lactobacillus reuteri: Their influence on adherence of E. coli to epithelial cells and inflammatory response","volume":"141","author":"Csank","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.aah5825","article-title":"Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8\u03b1\u03b1(+) T cells","volume":"357","author":"Chai","year":"2017","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1523-5378.2007.00565.x","article-title":"Role of probiotics in patients with Helicobacter pylori infection","volume":"12","author":"Franceschi","year":"2007","journal-title":"Helicobacter"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/MCG.0000000000000007","article-title":"Lactobacillus reuteri strain combination in Helicobacter pylori infection: A randomized, double-blind, placebo-controlled study","volume":"48","author":"Francavilla","year":"2014","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3389\/fimmu.2017.00598","article-title":"Leaky Gut As a Danger Signal for Autoimmune Diseases","volume":"8","author":"Mu","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s40168-017-0300-8","article-title":"Control of lupus nephritis by changes of gut microbiota","volume":"5","author":"Mu","year":"2017","journal-title":"Microbiome"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jaci.2010.10.018","article-title":"Tight junction defects in patients with atopic dermatitis","volume":"127","author":"Rafaels","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1007\/s10482-015-0448-9","article-title":"Effectiveness of Lactobacillus reuteri in infantile colic and colicky induced maternal depression: A prospective single blind randomized trial","volume":"107","author":"Mi","year":"2015","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_50","first-page":"107","article-title":"Epidemiology and risk factors for diverticular disease","volume":"89","author":"Violi","year":"2018","journal-title":"Acta Bio-Med. Atenei Parm."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1055\/s-0037-1607464","article-title":"Epidemiology and Pathophysiology of Diverticular Disease","volume":"31","author":"Munie","year":"2018","journal-title":"Clin. Colon Rectal Surg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/17474124.2018.1481746","article-title":"Pathophysiology of diverticular disease","volume":"12","author":"Schieffer","year":"2018","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_53","first-page":"829","article-title":"Diverticular disease practice points","volume":"46","author":"McSweeney","year":"2017","journal-title":"Aust. Fam. Physician"},{"key":"ref_54","first-page":"209","article-title":"Natural history of diverticular disease of the colon","volume":"22","author":"Bernades","year":"1986","journal-title":"Ann. Gastroenterol. D\u2019Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1001\/jama.2016.3592","article-title":"Diverticulosis and Diverticulitis","volume":"316","author":"Thompson","year":"2016","journal-title":"JAMA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.mayocp.2016.03.012","article-title":"Diverticulosis and Diverticulitis","volume":"91","author":"Feuerstein","year":"2016","journal-title":"Mayo Clin. Proc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/apt.13322","article-title":"Review article: The pathophysiology and medical management of diverticulosis and diverticular disease of the colon","volume":"42","author":"Tursi","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1053\/j.gastro.2018.12.033","article-title":"Epidemiology, Pathophysiology, and Treatment of Diverticulitis","volume":"156","author":"Strate","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"Itc65","DOI":"10.7326\/AITC201805010","article-title":"Acute Colonic Diverticulitis","volume":"168","author":"Swanson","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_60","first-page":"280","article-title":"Diverticular disease of the colon","volume":"85","author":"Germer","year":"2014","journal-title":"Der Chir. Z. Fur Alle Geb. Der Oper. Medizen"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/ajg.2015.302","article-title":"Temporal Trends in the Incidence and Natural History of Diverticulitis: A Population-Based Study","volume":"110","author":"Bharucha","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.gastrohep.2015.03.010","article-title":"Colonic diverticular disease. Treatment and prevention","volume":"38","year":"2015","journal-title":"Gastroenterol. Y Hepatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/MCG.0b013e31828003f6","article-title":"A randomized controlled study of mesalamine after acute diverticulitis: Results of the DIVA trial","volume":"47","author":"Stollman","year":"2013","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"327","DOI":"10.15403\/jgld-277","article-title":"Diverticular Disease: A Gut Microbiota Perspective","volume":"28","author":"Ticinesi","year":"2019","journal-title":"J. Gastrointest. Liver Dis. JGLD"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Piccioni, A., Franza, L., Brigida, M., Zanza, C., Torelli, E., Petrucci, M., Nicol\u00f2, R., Covino, M., and Candelli, M. (2021). Gut Microbiota and Acute Diverticulitis: Role of Probiotics in Management of This Delicate Pathophysiological Balance. J. Pers. Med., 11.","DOI":"10.3390\/jpm11040298"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s10151-020-02275-w","article-title":"Resolution of multiply recurrent and multifocal diverticulitis after fecal microbiota transplantation","volume":"24","author":"Meyer","year":"2020","journal-title":"Tech. Coloproctol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/ajg.2014.350","article-title":"Diverticulitis after fecal microbiota transplant for C. difficile infection","volume":"109","author":"Mandalia","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s10096-014-2162-3","article-title":"Fecal microbiome analysis as a diagnostic test for diverticulitis","volume":"33","author":"Daniels","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis. Off. Publ. Eur. Soc. Clin. Microbiol."},{"key":"ref_69","first-page":"208","article-title":"The natural history of symptomatic uncomplicated diverticular disease: A long-term follow-up study","volume":"34","author":"Tursi","year":"2021","journal-title":"Ann. Gastroenterol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1097\/MCG.0000000000000626","article-title":"Assessment of Fecal Microbiota and Fecal Metabolome in Symptomatic Uncomplicated Diverticular Disease of the Colon","volume":"50","author":"Tursi","year":"2016","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"79","DOI":"10.15403\/jgld.2014.1121.251.srw","article-title":"Probiotics in the Treatment of Diverticular Disease. A Systematic Review","volume":"25","author":"Lahner","year":"2016","journal-title":"J. Gastrointest. Liver Dis. JGLD"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2174\/1574887113666180402143140","article-title":"The Use of Probiotics in Different Phases of Diverticular Disease","volume":"13","author":"Ojetti","year":"2018","journal-title":"Rev. Recent Clin. Trials"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Garc\u00eda Contreras, A.A., V\u00e1squez Garibay, E.M., S\u00e1nchez Ram\u00edrez, C.A., and Fafutis Morris, M. (2020). Lactobacillus reuteri DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial. Nutrients, 12.","DOI":"10.3390\/nu12102971"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e541","DOI":"10.1016\/j.clcc.2018.05.001","article-title":"Inflammation-Modulating Effect of Butyrate in the Prevention of Colon Cancer by Dietary Fiber","volume":"17","author":"Chen","year":"2018","journal-title":"Clin. Colorectal Cancer"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"G969","DOI":"10.1152\/ajpgi.00072.2021","article-title":"Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency","volume":"320","author":"Liu","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_77","first-page":"281","article-title":"Anatomy and pathogenesis of diverticular disease","volume":"85","author":"Wedel","year":"2014","journal-title":"Der Chir. Z. Fur Alle Geb. Der Oper. Medizen"},{"key":"ref_78","first-page":"9126","article-title":"The efficacy of a mix of three probiotic strains in reducing abdominal pain and inflammatory biomarkers in acute uncomplicated diverticulitis","volume":"23","author":"Petruzziello","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"971","DOI":"10.12688\/f1000research.14299.1","article-title":"Recent advances in understanding and managing diverticulitis","volume":"7","author":"Severi","year":"2018","journal-title":"F1000Research"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1111\/j.1440-1746.2010.06444.x","article-title":"Role of probiotics in management of diverticular disease","volume":"25","author":"Narula","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_81","first-page":"127","article-title":"Gut microbiota, inflammation and symptomatic diverticular disease. New insights into an old and neglected disorder","volume":"19","author":"Quigley","year":"2010","journal-title":"J. Gastrointest. Liver Dis. JGLD"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijfoodmicro.2010.04.007","article-title":"Probiotic properties of non-conventional lactic acid bacteria: Immunomodulation by Oenococcus oeni","volume":"140","author":"Dewulf","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"ref_83","first-page":"5185","article-title":"Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis","volume":"11","author":"Peran","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Macia, L., Nanan, R., Hosseini-Beheshti, E., and Grau, G.E. (2019). Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010107"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"667987","DOI":"10.3389\/fcimb.2021.667987","article-title":"Characterization of Feces-Derived Bacterial Membrane Vesicles and the Impact of Their Origin on the Inflammatory Response","volume":"11","author":"Kameli","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molimm.2021.02.027","article-title":"Immunomodulatory roles and novel applications of bacterial membrane vesicles","volume":"134","author":"Gilmore","year":"2021","journal-title":"Mol. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15403\/jgld-554","article-title":"Hot Topics in Medical Treatment of Diverticular Disease: Evidence Pro and Cons","volume":"28","author":"Brandimarte","year":"2019","journal-title":"J. Gastrointest. Liver Dis. JGLD"},{"key":"ref_88","first-page":"83","article-title":"Diverticular Disease: A Review on Pathophysiology and Recent Evidence","volume":"89","author":"Piscopo","year":"2020","journal-title":"Ulst. Med. J."},{"key":"ref_89","first-page":"367","article-title":"Medical treatment of uncomplicated diverticular disease of the colon: Any progress?","volume":"56","author":"Guslandi","year":"2010","journal-title":"Minerva Gastroenterol. E Dietol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10151-015-1370-x","article-title":"Practice parameters for the treatment of colonic diverticular disease: Italian Society of Colon and Rectal Surgery (SICCR) guidelines","volume":"19","author":"Binda","year":"2015","journal-title":"Tech. Coloproctol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/8\/802\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:40:44Z","timestamp":1760164844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/8\/802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,5]]},"references-count":90,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["medicina57080802"],"URL":"https:\/\/doi.org\/10.3390\/medicina57080802","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,5]]}}}