{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T15:18:53Z","timestamp":1791731933312,"version":"4.3.4"},"reference-count":35,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: In children, hepatoblastoma preferentially is managed by liver resection (LR). However, in irresectable cases, liver transplantation (LT) is required. The aim of our study was to compare short- and long-term results after LR and LT for the curative treatment of hepatoblastoma. Materials and Methods: Retrospective analysis of all patients treated surgically for hepatoblastoma from January 2000 until December 2019 was performed. Demographic and clinical data were collected before and after surgery. The primary endpoints were disease free survival and patient survival. Results: In total, 38 patients were included into our analysis (n = 28 for LR, n = 10 for LT) with a median follow-up of 5 years. 36 patients received chemotherapy prior to surgery. Total hospital stay and intensive care unit (ICU) stay were significantly longer within the LT vs. the LR group (ICU 23 vs. 4 days, hospital stay 34 vs. 16 days, respectively; p &lt; 0.001). Surgical complications (\u2264Clavien\u2013Dindo 3a) were equally distributed in both groups (60% vs. 57%; p = 1.00). Severe complications (\u2265Clavien\u2013Dindo 3a) were more frequent after LT (50% vs. 21.4%; p = 0.11). Recurrence rates were 10.7% for LR and 0% for LT at 5 years after resection or transplantation (p = 0.94). Overall, 5-year survival was 90% for LT and 96% for LR (p = 0.44). Conclusions: In irresectable cases, liver transplantation reveals excellent outcomes in children with hepatoblastoma with an acceptable number of perioperative complications.<\/jats:p>","DOI":"10.3390\/medicina57080819","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T10:54:41Z","timestamp":1628765681000},"page":"819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Liver Transplantation Is Highly Effective in Children with Irresectable Hepatoblastoma"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-4788","authenticated-orcid":false,"given":"Simon","family":"Moosburner","sequence":"first","affiliation":[{"name":"Deparment of Surgery, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"},{"name":"BIH Charit\u00e9 (Digital) Clinician Scientist Program, Berlin Institute of Health, 10178 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Schmelzle","sequence":"additional","affiliation":[{"name":"Deparment of Surgery, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzel","family":"Sch\u00f6ning","sequence":"additional","affiliation":[{"name":"Deparment of Surgery, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"K\u00e4stner","sequence":"additional","affiliation":[{"name":"Deparment of Surgery, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Seika","sequence":"additional","affiliation":[{"name":"Deparment of Surgery, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1482-6255","authenticated-orcid":false,"given":"Brigitta","family":"Globke","sequence":"additional","affiliation":[{"name":"Deparment of Surgery, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"},{"name":"BIH Charit\u00e9 (Digital) Clinician Scientist Program, Berlin Institute of Health, 10178 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3337-4573","authenticated-orcid":false,"given":"Tomasz","family":"Dziodzio","sequence":"additional","affiliation":[{"name":"Deparment of Surgery, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Pratschke","sequence":"additional","affiliation":[{"name":"Deparment of Surgery, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-1673","authenticated-orcid":false,"given":"Robert","family":"\u00d6llinger","sequence":"additional","affiliation":[{"name":"Deparment of Surgery, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1013-7126","authenticated-orcid":false,"given":"Safak","family":"G\u00fcl-Klein","sequence":"additional","affiliation":[{"name":"Deparment of Surgery, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"ref_1","first-page":"812","article-title":"Liver Tumors in Children","volume":"13","author":"Litten","year":"2008","journal-title":"Oncology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1053\/jhep.2003.50375","article-title":"Epidemiology of primary hepatic malignancies in U.S. children","volume":"38","author":"Darbari","year":"2003","journal-title":"Hepatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cld.2011.03.011","article-title":"Liver Neoplasia in Children","volume":"15","author":"Hadzic","year":"2011","journal-title":"Clin. 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