{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:46:44Z","timestamp":1791499604541,"version":"4.3.4"},"reference-count":20,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Introduction: Sclerosing Extramedullary Hematopoietic Tumor (SEHT) is a very rare lesion associated with chronic myeloproliferative disorders (CMPD). SEHT can mimic morphologically, both macroscopically and microscopically, a wide variety of tumors\/lesions. Case presentation: We present the case of a female patient diagnosed with gallstones for which surgery was decided. Intraoperatively, a malignant tumor of extrahepatic bile ducts was suspected. A frozen section examination raised the suspicion of a mesenchymal tumor or an inflammatory pseudotumor. The histological evaluation of the permanent sections, supplemented with an immunohistochemical investigation (IHC), was the one that established the diagnosis of SEHT, based on the presence of areas of sclerosis, atypical CD31+ megakaryocytes, myeloid and erythroid elements. Conclusions: The authors present the difficulties of a morphological diagnosis on the frozen section and on permanent sections in the absence of relevant clinical information and make a review of the literature data dedicated to the subject.<\/jats:p>","DOI":"10.3390\/medicina57080824","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T02:32:10Z","timestamp":1629081130000},"page":"824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sclerosing Extramedullary Hematopoietic Tumor (SEHT) Mimicking a Malignant Bile Duct Tumor-Case Report and Literature Review"],"prefix":"10.3390","volume":"57","author":[{"given":"Sorin","family":"Dema","sequence":"first","affiliation":[{"name":"Radiotherapy Service, Emergency Clinical City Hospital, 300079 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulger","family":"Lazar","sequence":"additional","affiliation":[{"name":"Researching Future Surgery 2 Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-969X","authenticated-orcid":false,"given":"Robert","family":"Barna","sequence":"additional","affiliation":[{"name":"Anapatmol Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadeus","family":"Dobrescu","sequence":"additional","affiliation":[{"name":"Researching Future Surgery 2 Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alis Liliana Carmen","family":"Dema","sequence":"additional","affiliation":[{"name":"Anapatmol Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"},{"name":"Department II Microscopic Morphology\u2013Discipline of Morphopathology, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3883-2438","authenticated-orcid":false,"given":"Oana","family":"Popa","sequence":"additional","affiliation":[{"name":"Anapatmol Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"},{"name":"Department II Microscopic Morphology\u2013Discipline of Morphopathology, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Ionita","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Center for Malignant Hematological Diseases, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorina Maria","family":"Taban","sequence":"additional","affiliation":[{"name":"Anapatmol Research Center, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"},{"name":"Department II Microscopic Morphology\u2013Discipline of Morphopathology, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0046-8177(82)80076-2","article-title":"Fibrous hematopoietic tumors arising in agnogenic myeloid metaplasia","volume":"13","author":"Beckman","year":"1982","journal-title":"Hum. 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