{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:17:10Z","timestamp":1760235430778,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Hepatocellular carcinoma (HCC) typically presents in patients with a chronic liver disease and rarely develops in healthy liver, especially within an accessory liver lobe. We present a case of a healthy 64-years-old woman who showed a serum alpha-fetoprotein (AFP) value of 226.3 \u00b5g\/mL during a screening blood test. Past medical history was negative for chronic liver disease or cirrhosis. Intraoperative finding was an ovaloid mass connected with the second hepatic segment by a thin pedicle of hepatic tissue. Lesion was safely resected by laparoscopic approach. Histopathology analysis showed a trabecular hepatocellular carcinoma. After a 6-month follow up, there was no evidence of recurrent disease. This case report showed how serum AFP remains a highly sensitive marker, although the presentation of HCC was unusual. To our knowledge, this is the second case reported in the literature.<\/jats:p>","DOI":"10.3390\/medicina57080850","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T21:47:52Z","timestamp":1629668872000},"page":"850","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Potentially Misleading Hepatocellular Carcinoma"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8788-5590","authenticated-orcid":false,"given":"Ottavia","family":"De Simoni","sequence":"first","affiliation":[{"name":"Surgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology, IOV-IRCCS, Castelfranco Veneto (TV), Via Dei Carpani 16\/Z, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2295-7367","authenticated-orcid":false,"given":"Andrea","family":"Barina","sequence":"additional","affiliation":[{"name":"Surgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology, IOV-IRCCS, Castelfranco Veneto (TV), Via Dei Carpani 16\/Z, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-5762","authenticated-orcid":false,"given":"Mario","family":"Gruppo","sequence":"additional","affiliation":[{"name":"Surgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology, IOV-IRCCS, Castelfranco Veneto (TV), Via Dei Carpani 16\/Z, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Scapinello","sequence":"additional","affiliation":[{"name":"Anatomy and Histology Unit, Veneto Institute of Oncology, IOV-IRCCS, Castelfranco Veneto (TV), Via Dei Carpani 16\/Z, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios","family":"Mourmouras","sequence":"additional","affiliation":[{"name":"Anatomy and Histology Unit, Veneto Institute of Oncology, IOV-IRCCS, Castelfranco Veneto (TV), Via Dei Carpani 16\/Z, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Pilati","sequence":"additional","affiliation":[{"name":"Surgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology, IOV-IRCCS, Castelfranco Veneto (TV), Via Dei Carpani 16\/Z, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8630-9073","authenticated-orcid":false,"given":"Boris","family":"Franzato","sequence":"additional","affiliation":[{"name":"Surgical Oncology of Digestive Tract Unit, Veneto Institute of Oncology, IOV-IRCCS, Castelfranco Veneto (TV), Via Dei Carpani 16\/Z, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1470-2045(01)00486-7","article-title":"Global cancer statistics in the year 2000","volume":"2","author":"Parkin","year":"2001","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","article-title":"Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis","volume":"132","author":"Rudolph","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01784645","article-title":"A general review of anomalies of hepatic morphology and their clinical implications","volume":"7","author":"Champetier","year":"1985","journal-title":"Anat Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/00365520500377862","article-title":"Accessory liver lobes: A diagnostic and therapeutic challenge of their torsions","volume":"41","author":"Khan","year":"2006","journal-title":"Scand. 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