{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:13:39Z","timestamp":1790097219874,"version":"4.0.1"},"reference-count":23,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Tubulocystic renal cell carcinoma (RCC) is a rare subtype of RCC that was recently included in the 2016 World Health Organization classification of tumors of the kidney. Most of these tumors exhibit indolent behavior with low metastatic potential. However, here we report a case of recurrent tubulocystic RCC with aggressive features in the retroperitoneum and contralateral kidney treated with targeted agents and radiofrequency ablation.<\/jats:p>","DOI":"10.3390\/medicina57080851","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T21:47:52Z","timestamp":1629668872000},"page":"851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tubulocystic Renal Cell Carcinoma Is Not an Indolent Tumor: A Case Report of Recurrences in the Retroperitoneum and Contralateral Kidney"],"prefix":"10.3390","volume":"57","author":[{"given":"Tae-Soo","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Urology, Kyung Hee University College of Medicine, Seoul 05278, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Gi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology, Kyung Hee University College of Medicine, Seoul 05278, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Yeoun","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kyung Hee University College of Medicine, Seoul 05278, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-7481","authenticated-orcid":false,"given":"Gyeong-Eun","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Urology, Kyung Hee University College of Medicine, Seoul 05278, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eururo.2016.02.029","article-title":"The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours","volume":"70","author":"Moch","year":"2016","journal-title":"Eur. Urol."},{"key":"ref_2","first-page":"118","article-title":"Tubulocystic Renal Cell Carcinoma: A Great Imitator","volume":"18","author":"Banerjee","year":"2016","journal-title":"Rev. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/PAS.0b013e3181872d3f","article-title":"Tubulocystic carcinoma of the kidney: Clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma","volume":"33","author":"Amin","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/PAS.0b013e318150df1d","article-title":"Tubulocystic carcinoma of the kidney: Clinicopathologic and molecular characterization","volume":"32","author":"Yang","year":"2008","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.urology.2011.01.038","article-title":"Unique case of tubulocystic carcinoma of the kidney with sarcomatoid features: A new entity","volume":"78","author":"Bhullar","year":"2011","journal-title":"Urology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1007\/s00330-015-3923-9","article-title":"Tubulocystic renal cell carcinoma: A new radiological entity","volume":"26","author":"Cornelis","year":"2016","journal-title":"Eur. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1016\/j.juro.2011.03.043","article-title":"Tubulocystic carcinoma of the kidney","volume":"185","author":"MacLennan","year":"2011","journal-title":"J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.crad.2018.09.003","article-title":"Contemporary update on imaging of cystic renal masses with histopathological correlation and emphasis on patient management","volume":"74","author":"Narayanasamy","year":"2019","journal-title":"Clin. Radiol."},{"key":"ref_9","first-page":"451","article-title":"Tubulocystic renal cell carcinoma disguised as a renal cyst","volume":"68","author":"Oderda","year":"2016","journal-title":"Minerva Urol. E Nefrol. Ital. J. Urol. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/his.12840","article-title":"Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma","volume":"68","author":"Tran","year":"2016","journal-title":"Histopathology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/PAS.0b013e3181a13e7b","article-title":"Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidney","volume":"33","author":"Osunkoya","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1097\/PAS.0b013e3181be22d1","article-title":"Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: Implications for pathologic classification","volume":"33","author":"Zhou","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.humpath.2012.11.015","article-title":"Tubulocystic carcinoma of the kidney with poorly differentiated foci: A series of 3 cases with fluorescence in situ hybridization analysis","volume":"44","author":"Cheng","year":"2013","journal-title":"Hum. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1097\/PAS.0000000000000719","article-title":"Tubulocystic Carcinoma of the Kidney with Poorly Differentiated Foci: A Frequent Morphologic Pattern of Fumarate Hydratase-deficient Renal Cell Carcinoma","volume":"40","author":"Smith","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_15","first-page":"11124","article-title":"Tubulocystic renal cell carcinoma with poorly differentiated foci is indicative of aggressive behavior: Clinicopathologic study of two cases and review of the literature","volume":"8","author":"Zhao","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101236","DOI":"10.1016\/j.eucr.2020.101236","article-title":"Tubulocystic renal cell carcinoma with poorly differentiated foci and loss of fumarate hydratase: A case report","volume":"33","author":"Alahmadi","year":"2020","journal-title":"Urol. Case Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/annonc\/mdn408","article-title":"Sunitinib in the treatment of tubulocystic carcinoma of the kidney. A case report","volume":"19","author":"Mego","year":"2008","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"ref_18","first-page":"696","article-title":"Tubulocystic carcinoma of the kidney","volume":"102","author":"Teramoto","year":"2011","journal-title":"Nihon Hinyokika Gakkai Zasshi Jpn. J. Urol."},{"key":"ref_19","first-page":"569","article-title":"A Case of Metastatic Tubulocystic Carcinoma of the Kidney Treated with Molecularly Targeted Therapy","volume":"62","author":"Urabe","year":"2016","journal-title":"Hinyokika Kiyo Acta Urol. Jpn."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.6004\/jnccn.2019.0054","article-title":"NCCN Guidelines Insights: Kidney Cancer, Version 2. 2020","volume":"17","author":"Motzer","year":"2019","journal-title":"J. Natl. Compr. Cancer Netw. JNCCN"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000447218","article-title":"Radiofrequency Ablation of Small Renal Masses: Outcomes, Complications and Effects on Renal Function","volume":"11","author":"Curry","year":"2017","journal-title":"Curr. Urol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3348\/kjr.2016.17.5.763","article-title":"CT-Guided Radiofrequency Ablation of T1a Renal Cell Carcinoma in Korea: Mid-Term Outcomes","volume":"17","author":"Kim","year":"2016","journal-title":"Korean J. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gonnet, A., Salabert, L., Roubaud, G., Catena, V., Brouste, V., Buy, X., Gross Goupil, M., Ravaud, A., and Palussi\u00e8re, J. (2019). Renal cell carcinoma lung metastases treated by radiofrequency ablation integrated with systemic treatments: Over 10 years of experience. 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