{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:19:49Z","timestamp":1793398789538,"version":"4.5.0"},"reference-count":71,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The number of aortic stenosis patients in Western countries is increasing, along with better life conditions and expectancies. Presently, the volume of percutaneous transcatheter aortic valve implantations (TAVIs) is incessantly increasing, and has already overcome the surgical replacement procedure volume. According to the literature, TAVI is a feasible procedure even among low surgical risk patients, and American guidelines have extended the indications for TAVI, including shifting patient evaluations from high\/low STS scores to old\/young patients, a \u201cparadigm shift\u201d of aortic stenosis evaluation. As a result, low-risk young (&lt;75 years-old) population management could be the next challenge in cardiology. To manage the life conditions of a 65 year old patient affected by aortic stenosis who is undergoing TAVI, one of the most crucial issue will be bioprosthesis durability and the appropriate intervention to make in cases of valve dysfunction or failure.<\/jats:p>","DOI":"10.3390\/medicina57090883","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T22:49:51Z","timestamp":1630363791000},"page":"883","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transcatheter Aortic Valve Implantation in Younger Patients: A New Challenge"],"prefix":"10.3390","volume":"57","author":[{"given":"Giacomo","family":"Virgili","sequence":"first","affiliation":[{"name":"Cardiothoracovascular Department, Careggi Hospital, 50134 Florence, Italy"},{"name":"Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore Mario","family":"Romano","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Valenti","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Careggi Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Migliorini","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Careggi Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-3016","authenticated-orcid":false,"given":"Pierluigi","family":"Stef\u00e0no","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Careggi Hospital, 50134 Florence, Italy"},{"name":"Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8101-4695","authenticated-orcid":false,"given":"Niccol\u00f2","family":"Marchionni","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Careggi Hospital, 50134 Florence, Italy"},{"name":"Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazario","family":"Carrabba","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Careggi Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: A population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","article-title":"Aortic Stenosis in the Elderly: Disease Prevalence and Number of Candidates for Transcatheter Aortic Valve Replacement: A Meta-Analysis and Modeling Study","volume":"62","author":"Osnabrugge","year":"2013","journal-title":"J. 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