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Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: A meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1111\/bcp.14362","article-title":"Major bleeding risk associated with oral anticoagulant in real clinical practice. A multicentre 3-year period population-based prospective cohort study","volume":"86","author":"Bouget","year":"2020","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"k2505","DOI":"10.1136\/bmj.k2505","article-title":"Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: Cohort study in primary care","volume":"362","author":"Vinogradova","year":"2018","journal-title":"BMJ"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ajem.2016.09.053","article-title":"Idarucizumab and factor Xa reversal agents: Role in hospital guidelines and protocols","volume":"34","author":"Huisman","year":"2016","journal-title":"Am. J. Emerg. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/TA.0000000000001245","article-title":"Compared to warfarin, direct oral anticoagulants are associated with lower mortality in patients with blunt traumatic intracranial hemorrhage: A TQIP study","volume":"81","author":"Feeney","year":"2016","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/TA.0000000000002518","article-title":"Consequences of pre-injury utilization of direct oral anticoagulants in patients with traumatic brain injury: A systematic review and meta-analysis","volume":"88","author":"Nederpelt","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2147\/OAEM.S267069","article-title":"Preparing for the Maximum Emergency with a Simulation: A Table-Top Test to Evaluate Bed Surge Capacity and Staff Compliance with Training","volume":"12","author":"Ceresa","year":"2020","journal-title":"Open Access Emerg. Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Savioli, G., Ceresa, I.F., Caneva, L., Gerosa, S., and Ricevuti, G. (2021). Trauma-Induced Coagulopathy: Overview of an Emerging Medical Problem from Pathophysiology to Outcomes. 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