{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:41:37Z","timestamp":1760168497575,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>We report the case of a 65-year-old man with acute GFR decline to 37 mL\/min and uncontrolled high blood pressure. He was suspected for renovascular hypertension and underwent a renal color Doppler ultrasound scan that detected a bilateral atherosclerotic renal artery stenosis. A digital selective angiography by percutaneous transluminal angioplasty and stenting (PTRAs) was successfully performed. Blood pressure rapidly normalized, GFR increased within a few days, and proteinuria disappeared thereafter. These clinical goals were accompanied by a significant increase of circulating renal stem cells (RSC) and a slight increase of resistive index (RI) in both kidneys. This single observation suggests the need for extensive studies aimed at evaluating the predictive power of RI and RSC in detecting post-ischemic renal repair mechanisms.<\/jats:p>","DOI":"10.3390\/medicina57090944","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T02:41:07Z","timestamp":1631068867000},"page":"944","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ischemic Nephropaty: The Role of the Renal Artery Stenosis Revascularization on Renal Stem Cells"],"prefix":"10.3390","volume":"57","author":[{"given":"Rosario","family":"Cianci","sequence":"first","affiliation":[{"name":"Nephrologic Unit, Department of Translational and Precision Medicine, University of Rome \u2018La Sapienza\u2019, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo Marco","family":"Perrotta","sequence":"additional","affiliation":[{"name":"Nephrologic Unit, Department of Translational and Precision Medicine, University of Rome \u2018La Sapienza\u2019, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-765X","authenticated-orcid":false,"given":"Antonietta","family":"Gigante","sequence":"additional","affiliation":[{"name":"Nephrologic Unit, Department of Translational and Precision Medicine, University of Rome \u2018La Sapienza\u2019, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Errigo","sequence":"additional","affiliation":[{"name":"Nephrologic Unit, Department of Translational and Precision Medicine, University of Rome \u2018La Sapienza\u2019, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Ferri","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Unit\u2014San Salvatore Hospital, Department of Clinical Medicine and Public Health, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Cianci","sequence":"additional","affiliation":[{"name":"Nephrologic Unit, Department of Translational and Precision Medicine, University of Rome \u2018La Sapienza\u2019, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-9416","authenticated-orcid":false,"given":"Mariadelina","family":"Simeoni","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, 80138 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3071-1893","authenticated-orcid":false,"given":"Sandro","family":"Mazzaferro","sequence":"additional","affiliation":[{"name":"Nephrologic Unit, Department of Translational and Precision Medicine, University of Rome \u2018La Sapienza\u2019, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-2954","authenticated-orcid":false,"given":"Silvia","family":"Lai","sequence":"additional","affiliation":[{"name":"Nephrologic Unit, Department of Translational and Precision Medicine, University of Rome \u2018La Sapienza\u2019, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s40620-020-00733-0","article-title":"Atherosclerotic-nephropathy: An updated narrative review","volume":"34","author":"Simeoni","year":"2021","journal-title":"J. Nephrol."},{"key":"ref_2","first-page":"hcaa295","article-title":"Resistant hypertension: Drug-eluting balloon for revascularization of bilateral renal fibromuscular dysplasia","volume":"114","author":"Cianci","year":"2020","journal-title":"QJM"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100475","DOI":"10.1016\/j.ijcha.2020.100475","article-title":"Percutaneous transluminal renal angioplasty of global kidney ischemia improves renal function and blood pressure","volume":"27","author":"Abboud","year":"2020","journal-title":"IJC Heart Vasc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"901","DOI":"10.7326\/0003-4819-145-12-200612190-00143","article-title":"Effectiveness of management strategies for renal artery stenosis: A systematic review","volume":"145","author":"Balk","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Patel, V., and Preedy, V. (2016). Renal Arterial Resistance Index. Biomarkers in Disease: Methods, Discoveries and Applications, Springer.","DOI":"10.1007\/978-94-007-7693-7"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1471-4914(01)02016-0","article-title":"Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century","volume":"7","author":"Caplan","year":"2001","journal-title":"Trends Mol. Med."},{"key":"ref_7","first-page":"1035","article-title":"Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury","volume":"14","author":"Herrera","year":"2004","journal-title":"Int. J. Mol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.semnephrol.2019.10.008","article-title":"The Role of Hypoxia in Ischemic Chronic Kidney Disease","volume":"39","author":"Textor","year":"2019","journal-title":"Semin Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCINTERVENTIONS.112.972596","article-title":"Changes in Glomerular Filtration Rate After Renal Revascularization Correlate With Microvascular Hemodynamics and Inflammation in Swine Renal Artery Stenosis","volume":"5","author":"Eirin","year":"2012","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1681\/ASN.2006030275","article-title":"Isolation and Characterization of Kidney-Derived Stem Cells","volume":"17","author":"Gupta","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/9\/944\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:58:28Z","timestamp":1760165908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/9\/944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["medicina57090944"],"URL":"https:\/\/doi.org\/10.3390\/medicina57090944","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2021,9,8]]}}}