{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:44:02Z","timestamp":1784371442632,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Large radicular cysts of the maxilla present a clinical challenge, as they may cause recurrent infection, severe alveolar bone loss and disruption of the nasal and maxillary sinus floors. The aim of this study was to evaluate the effect of previous root canal treatment on the clinical presentation of large maxillary radicular cysts. Materials and Methods: All cases of radicular cysts treated at the Oral and Maxillofacial Surgery Department of a tertiary public hospital over a period of six years (2012\u20132018) were evaluated. Histologically confirmed radicular cysts of the maxilla with a maximal dimension of over 15 mm were included. Demographic data of the patients, clinical presentation and radiographic features of the lesions were analyzed. Results: A total of 211 inflammatory cysts were treated in the study period, of these 54 histologically diagnosed radicular cysts in the maxilla were found to have a maximal dimension of over 15 mm. The mean age of patients with large maxillary radicular cysts was 43.3 years, 57.6% of which were male and 42.4% female. The lateral incisor was the most common tooth affected (46.3%). The mean size of the large radicular cysts was 25 mm. Then, 83.8% of the cysts were observed in teeth with previous endodontic treatment. Teeth without endodontic treatment presented clinically with significantly fewer acute symptoms in comparison to teeth with previous endodontic treatment. Conclusions: the vast majority (83.8%) of large maxillary radicular cysts were associated with endodontically treated teeth. Previous endodontic treatment was correlated to increased frequency of clinical symptoms.<\/jats:p>","DOI":"10.3390\/medicina57090991","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T22:34:01Z","timestamp":1632263641000},"page":"991","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Development of Large Radicular Cysts in Endodontically Versus Non-Endodontically Treated Maxillary Teeth"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-7397","authenticated-orcid":false,"given":"Ruth","family":"Schvartzman Cohen","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Surgery Department\u2014Rabin Medical Center, Beilinson Campus, 39 Ze\u2019ev Jabotinsky St, Petach Tikvah 4941492, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Goldberger","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dental Medicine, Tel Aviv University, Ramat Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Merzlak","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dental Medicine, Tel Aviv University, Ramat Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5824-0379","authenticated-orcid":false,"given":"Igor","family":"Tsesis","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dental Medicine, Tel Aviv University, Ramat Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-4978","authenticated-orcid":false,"given":"Gavriel","family":"Chaushu","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Department\u2014Rabin Medical Center, Beilinson Campus, 39 Ze\u2019ev Jabotinsky St, Petach Tikvah 4941492, Israel"},{"name":"Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tel Aviv University, Ramat Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5111-8496","authenticated-orcid":false,"given":"Gal","family":"Avishai","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Department\u2014Rabin Medical Center, Beilinson Campus, 39 Ze\u2019ev Jabotinsky St, Petach Tikvah 4941492, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dental Medicine, Tel Aviv University, Ramat Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1079-2104(00)70098-9","article-title":"Comparison of clinical and histologic diagnoses in periapical lesions","volume":"89","author":"Kuc","year":"2000","journal-title":"Oral Surg. 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