{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T07:41:26Z","timestamp":1771746086833,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Acute kidney injury (AKI) affects the survival rate of kidney transplant organs and patients. Acute rejection (AR) due to AKI may lead to kidney transplantation failure. It is known that there is a relationship between human leukocyte antigen-G (HLA-G), which is involved in immune regulation, and AR in transplant patients. Moreover, 14-bp insertion\/deletion polymorphism in the 3\u2032 untranslated region (UTR) region of the HLA-G gene is known to affect HLA-G expression. However, its relationship to AR is still controversial. The aim of this study was to investigate whether HLA-G 14-bp insertion\/deletion polymorphism contributed to the development of AR in kidney transplant patients using a meta-analysis. Materials and Methods: To perform our meta-analysis, eligible studies about HLA-G 14-bp insertion\/deletion polymorphism and AR were searched in electronic databases until 1 June 2021. Finally, a total of 336 patients with AR and 952 patients without AR in relation to kidney transplantation were analyzed from a total of nine studies. Results: In our results, the Del allele and Ins\/Del+Del\/Del and Del\/Del genotypes significantly increased susceptibility of AR in Asian populations [odds ratio (OR) = 2.359, 95% confidence interval (CI) = 1.568\u20133.550, p = 3.8 \u00d7 10\u22125; OR = 3.357, 95% CI = 1.769\u20136.370, p = 0.002; OR = 2.750, 95% CI = 1.354\u20135.587, p = 0.0052 in each model, respectively]. Conclusions: Evidence of the present results indicate that HLA-G 14-bp insertion\/deletion polymorphism is associated with susceptibility to AR in the Asian population.<\/jats:p>","DOI":"10.3390\/medicina57101007","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T10:39:20Z","timestamp":1632739160000},"page":"1007","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["HLA-G 14bp Ins\/Del Polymorphism in the 3\u2032UTR Region and Acute Rejection in Kidney Transplant Recipients: An Updated Meta-Analysis"],"prefix":"10.3390","volume":"57","author":[{"given":"Sang Wook","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry, Kyung Hee University, Seoul 02453, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunkyung","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Graduate School, Kyung Hee University, Seoul 02453, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wonwoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Medicine, Graduate School, Kyung Hee University, Seoul 02453, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minseok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Graduate School, Kyung Hee University, Seoul 02453, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9364-2947","authenticated-orcid":false,"given":"Eo Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Graduate School, Kyung Hee University, Seoul 02453, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Hwan","family":"Kwack","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, University at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Developmental Biology, Graduate School of Dentistry, Kyung Hee University, Seoul 02453, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6386-803X","authenticated-orcid":false,"given":"Ok Hyung","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul 02453, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Kwon","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul 02453, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Yeon","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of Dental Pharmacology, School of Dentistry, Dankook University, Cheonan 16890, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"WHO (1946). 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