{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:23:29Z","timestamp":1760235809141,"version":"build-2065373602"},"reference-count":16,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Endothelial dysfunction is associated with exercise intolerance and adverse cardiovascular events. Transcatheter aortic valve implantation (TAVI) is applied to treat elderly patients with severe aortic stenosis, but less is known about the impact of TAVI on endothelial dysfunction, which can be assessed by measuring flow-mediated vasodilation (FMD). In this parameter, a low value indicates impaired endothelial function. Materials and Methods: Vascular endothelial function was evaluated by FMD of the brachial artery just before and one week after TAVI. Factors associated with the normalization of FMD and their prognostic impact were investigated. Results: Fifty-one patients who underwent TAVI procedure (median 86 years old, 12 men) were included. FMD improved significantly from baseline to one week following TAVI (from 5.3% [3.7%, 6.7%] to 6.3% [4.7%, 8.1%], p &lt; 0.001). Among 33 patients with baseline low FMD (\u22646.0%), FMD normalized up to &gt;6.0% following TAVI in 15 patients. Baseline higher cardiac index was independently associated with normalization of FMD following TAVI (odds ratio 11.8, 95% confidence interval 1.12\u2013124; p &lt; 0.04). Conclusions: Endothelial dysfunction improved following TAVI in many patients with severe aortic stenosis. The implication of this finding is the next concern.<\/jats:p>","DOI":"10.3390\/medicina57101008","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T10:39:20Z","timestamp":1632739160000},"page":"1008","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improvement in Vascular Endothelial Function following Transcatheter Aortic Valve Implantation"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7551-3431","authenticated-orcid":false,"given":"Shuhei","family":"Tanaka","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-7637","authenticated-orcid":false,"given":"Teruhiko","family":"Imamura","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Ushijima","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-8427","authenticated-orcid":false,"given":"Mitsuo","family":"Sobajima","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9747-2511","authenticated-orcid":false,"given":"Hiroshi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadakazu","family":"Hirai","sequence":"additional","affiliation":[{"name":"Fujikoshi Hospital, Toyama 930-0964, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Kinugawa","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/eurheartj\/9.suppl_E.57","article-title":"The natural history of aortic valve stenosis","volume":"9","author":"Horstkotte","year":"1988","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients","volume":"380","author":"Mack","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"H2","DOI":"10.1152\/ajpheart.00471.2010","article-title":"Assessment of flow-mediated dilation in humans: A methodological and physiological guideline","volume":"300","author":"Thijssen","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.CIR.0000112565.60887.1E","article-title":"Clinical Correlates and Heritability of Flow-Mediated Dilation in the Community: The Framingham Heart Study","volume":"109","author":"Benjamin","year":"2004","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jacc.2008.08.074","article-title":"Persistent Impairment of Endothelial Vasomotor Function Has a Negative Impact on Outcome in Patients With Coronary Artery Disease","volume":"53","author":"Kitta","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0735-1097(02)01976-9","article-title":"Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women","volume":"40","author":"Modena","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jacc.2004.10.081","article-title":"Reduced Systemic Arterial Compliance Impacts Significantly on Left Ventricular Afterload and Function in Aortic Stenosis: Implications for Diagnosis and Treatment","volume":"46","author":"Briand","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00380-014-0475-x","article-title":"Brachial artery diameter has a predictive value in the improvement of flow-mediated dilation after aortic valve replacement for aortic stenosis","volume":"30","author":"Takata","year":"2014","journal-title":"Heart Vessel."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.4244\/EIJY14M10_02","article-title":"Improved endothelial function and decreased levels of endothelium-derived microparticles after transcatheter aortic valve implantation","volume":"10","author":"Horn","year":"2015","journal-title":"EuroIntervention"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014An Inflammatory Disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0735-1097(02)02622-0","article-title":"Aortic valve sclerosis is associatedwith systemic endothelial dysfunction","volume":"41","author":"Poggianti","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"van Ooij, P., Markl, M., Collins, J.D., Carr, J.C., Rigsby, C., Bonow, R.O., Malaisrie, S.C., McCarthy, P.M., Fedak, P.W., and Barker, A.J. (2017). Aortic Valve Stenosis Alters Expression of Regional Aortic Wall Shear Stress: New Insights From a 4-Dimensional Flow Magnetic Resonance Imaging Study of 571 Subjects. J. Am. Heart Assoc., 6.","DOI":"10.1161\/JAHA.117.005959"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1182\/blood-2005-06-2326","article-title":"Shear stress affects the intracellular distribution of eNOS: Direct demonstration by a novel in vivo technique","volume":"106","author":"Cheng","year":"2005","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijsu.2019.01.014","article-title":"The effect of surgical versus transcatheter aortic valve replacement on endothelial function. An observational study","volume":"63","author":"Moscarelli","year":"2019","journal-title":"Int. J. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1053\/j.jvca.2016.06.009","article-title":"Pulmonary and Systemic Vascular Resistances After Cardiopulmonary Bypass: Role of Hemolysis","volume":"31","author":"Rezoagli","year":"2017","journal-title":"J. Cardiothorac. Vasc. Anesthesia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijcard.2021.03.062","article-title":"Patients with aortic stenosis exhibit early improved endothelial function following transcatheter aortic valve replacement: The eFAST study","volume":"332","author":"Comella","year":"2021","journal-title":"Int. J. Cardiol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/10\/1008\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:04:26Z","timestamp":1760166266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/10\/1008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,24]]},"references-count":16,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["medicina57101008"],"URL":"https:\/\/doi.org\/10.3390\/medicina57101008","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2021,9,24]]}}}