{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:32:47Z","timestamp":1793964767358,"version":"4.8.0"},"reference-count":287,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01DK119085"],"award-info":[{"award-number":["U01DK119085"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AR073614"],"award-info":[{"award-number":["1R01AR073614"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24DK122927"],"award-info":[{"award-number":["U24DK122927"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stanley J. Glaser Foundation","award":["UM SJG 2021-1"],"award-info":[{"award-number":["UM SJG 2021-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by prolonged hyperglycemia that leads to long-term health consequences. It is estimated that impaired healing of diabetic wounds affects approximately 25% of all patients with diabetes mellitus, often resulting in lower limb amputation, with subsequent high economic and psychosocial costs. The hyperglycemic environment promotes the formation of biofilms and makes diabetic wounds difficult to treat. In this review, we present updates regarding recent advances in our understanding of the pathophysiology of diabetic wounds focusing on impaired angiogenesis, neuropathy, sub-optimal chronic inflammatory response, barrier disruption, and subsequent polymicrobial infection, followed by current and future treatment strategies designed to tackle the various pathologies associated with diabetic wounds. Given the alarming increase in the prevalence of diabetes, and subsequently diabetic wounds, it is imperative that future treatment strategies target multiple causes of impaired healing in diabetic wounds.<\/jats:p>","DOI":"10.3390\/medicina57101072","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T21:37:29Z","timestamp":1633901849000},"page":"1072","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":834,"title":["Diabetic Wound-Healing Science"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1137-6850","authenticated-orcid":false,"given":"Jamie L.","family":"Burgess","sequence":"first","affiliation":[{"name":"Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-1549","authenticated-orcid":false,"given":"W. Austin","family":"Wyant","sequence":"additional","affiliation":[{"name":"Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Abdo Abujamra","sequence":"additional","affiliation":[{"name":"Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Kirsner","sequence":"additional","affiliation":[{"name":"Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5114-9524","authenticated-orcid":false,"given":"Ivan","family":"Jozic","sequence":"additional","affiliation":[{"name":"Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"031503","DOI":"10.1063\/5.0046682","article-title":"Functional hydrogels for diabetic wound management","volume":"5","author":"Gao","year":"2021","journal-title":"APL Bioeng."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"120423","DOI":"10.1016\/j.ijpharm.2021.120423","article-title":"3D scaffolds in the treatment of diabetic foot ulcers: New trends vs. conventional approaches","volume":"599","author":"Glover","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/01.GOX.0000558322.25327.77","article-title":"Abstract 48","volume":"7","author":"Hajhosseini","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/acs.accounts.0c00864","article-title":"Strategy for Treatment of Infected Diabetic Foot Ulcers","volume":"54","author":"Chang","year":"2021","journal-title":"Accounts Chem. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic Foot Ulcers and Their Recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1475-2840-12-135","article-title":"Cardiac implications of hypoglycaemia in patients with diabetes\u2014A systematic review","volume":"12","author":"Hanefeld","year":"2013","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1001\/jama.287.19.2570","article-title":"Diabetes and Atherosclerosis","volume":"287","author":"Beckman","year":"2002","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2337\/diabetes.53.3.721","article-title":"Impaired Pressure-Induced Vasodilation at the Foot in Young Adults With Type 1 Diabetes","volume":"53","author":"Koitka","year":"2004","journal-title":"Diabetes"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1039\/C3LC50105A","article-title":"Study of endothelial cell apoptosis using fluorescence resonance energy transfer (FRET) biosensor cell line with hemodynamic microfluidic chip system","volume":"13","author":"Yu","year":"2013","journal-title":"Lab Chip"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/dmrr.613","article-title":"Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction","volume":"22","author":"Piconi","year":"2006","journal-title":"Diabetes\/Metabolism Res. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1600-0625.2011.01364.x","article-title":"A long-standing hyperglycaemic condition impairs skin barrier by accelerating skin ageing process","volume":"20","author":"Park","year":"2011","journal-title":"Exp. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s40257-017-0275-z","article-title":"Cutaneous Manifestations of Diabetes Mellitus: A Review","volume":"18","author":"Lima","year":"2017","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.bbrc.2017.06.166","article-title":"Skin changes in streptozotocin-induced diabetic rats","volume":"490","author":"Andrade","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/exd.13466","article-title":"Impaired permeability and antimicrobial barriers in type 2 diabetes skin are linked to increased serum levels of advanced glycation end-product","volume":"27","author":"Kim","year":"2017","journal-title":"Exp. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1534734609337151","article-title":"Altered Molecular Mechanisms of Diabetic Foot Ulcers","volume":"8","author":"Blakytny","year":"2009","journal-title":"Int. J. Low. Extremity Wounds"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1083\/jcb.145.6.1309","article-title":"Targeted Disruption of the LAMA3 Gene in Mice Reveals Abnormalities in Survival and Late Stage Differentiation of Epithelial Cells","volume":"145","author":"Ryan","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Dworza\u0144ski, J., Strycharz-Dudziak, M., Kliszczewska, E., Kie\u0142czykowska, M., Dworza\u0144ska, A., Drop, B., and Polz-Dacewicz, M. (2020). Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity in patients with diabetes mellitus type 2 infected with Epstein-Barr virus. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0230374"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/8852759","article-title":"The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing","volume":"2021","author":"Deng","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.devcel.2014.08.002","article-title":"C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair","volume":"31","author":"Xu","year":"2014","journal-title":"Dev. Cell"},{"key":"ref_20","first-page":"1159","article-title":"The Role of Oxygen in Wound Healing: A Review of the Literature","volume":"34","author":"Rodriguez","year":"2008","journal-title":"Dermatol. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11892-003-0005-1","article-title":"Update on the pathogenesis of diabetic neuropathy","volume":"3","author":"Obrosova","year":"2003","journal-title":"Curr. Diabetes Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/j.pain.0000000000001141","article-title":"Itch and neuropathic itch","volume":"159","author":"Hachisuka","year":"2018","journal-title":"Pain"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2337\/dc09-0632","article-title":"Truncal Pruritus of Unknown Origin May Be a Symptom of Diabetic Polyneuropathy","volume":"33","author":"Yamaoka","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/01.sap.0000221465.69826.b7","article-title":"Wound Healing in Denervated Tissue","volume":"57","author":"Barker","year":"2006","journal-title":"Ann. Plast. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Volmer-Thole, M., and Lobmann, R. (2016). Neuropathy and Diabetic Foot Syndrome. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060917"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/MOL.0000000000000770","article-title":"Lipids and peripheral neuropathy","volume":"32","author":"Iqbal","year":"2021","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1055\/s-2004-821313","article-title":"Topical Application of Nerve Growth Factor in Human Diabetic Foot Ulcers. A Study of Three Cases","volume":"112","author":"Generini","year":"2004","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0140-6736(00)03212-8","article-title":"NGF, a useful tool in the treatment of chronic vasculitic ulcers in rheumatoid arthritis","volume":"356","author":"Tuveri","year":"2000","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Azhar, A., Basheer, M., Abdelgawad, M.S., Roshdi, H., and Kamel, M.F. (2021). Prevalence of Peripheral Arterial Disease in Diabetic Foot Ulcer Patients and its Impact in Limb Salvage. Int. J. Low. Extremity Wounds.","DOI":"10.1177\/15347346211027063"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12020-020-02431-0","article-title":"Predictors of healing, ulcer recurrence and persistence, amputation and mortality in type 2 diabetic patients with diabetic foot: A 10-year retrospective cohort study","volume":"71","author":"Gazzaruso","year":"2020","journal-title":"Endocrine"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Orioli, L., Hammer, F., Berg, B.V., Putineanu, D., Maiter, D., and Vandeleene, B. (2021). Prevalence, Characteristics, and Prognosis of Peripheral Arterial Disease in Patients With Diabetic Charcot Foot. J. Foot Ankle Surg.","DOI":"10.1053\/j.jfas.2021.04.021"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Iacopi, E., Coppelli, A., Goretti, C., Bargellini, I., Cicorelli, A., Cioni, R., and Piaggesi, A. (2021). Effect of Direct Endovascular Revascularization Based on the Angiosome Model on Risk of Major Amputations and Life Expectancy in Type 2 Diabetic Patients with Critical Limb Ischemia and Foot Ulceration. J. Am. Podiatr. Med Assoc., 111.","DOI":"10.7547\/18-130"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00270-020-02604-4","article-title":"Successful Revascularization has a Significant Impact on Limb Salvage Rate and Wound Healing for Patients with Diabetic Foot Ulcers: Single-Centre Retrospective Analysis with a Multidisciplinary Approach","volume":"43","author":"Caetano","year":"2020","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1526602819885131","article-title":"Healing of Diabetic Neuroischemic Foot Wounds With vs Without Wound-Targeted Revascularization: Preliminary Observations From an 8-Year Prospective Dual-Center Registry","volume":"27","author":"Alexandrescu","year":"2019","journal-title":"J. Endovasc. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jvs.2021.03.017","article-title":"Evaluation of revascularization benefit quartiles using the Wound, Ischemia, and foot Infection classification system for diabetic patients with chronic limb-threatening ischemia","volume":"74","author":"Hicks","year":"2021","journal-title":"J. Vasc. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e26468","DOI":"10.2196\/26468","article-title":"Mobile Health\u2013Based Thermometer for Monitoring Wound Healing After Endovascular Therapy in Patients With Chronic Foot Ulcer: Prospective Cohort Study","volume":"9","author":"Lin","year":"2021","journal-title":"JMIR mHealth uHealth"},{"key":"ref_37","first-page":"1","article-title":"Effect of Hypoxia on Gene Expression in Cell Populations Involved in Wound Healing","volume":"2019","author":"Magnavacca","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2147\/VHRM.S307366","article-title":"Differentiation of Diabetic Foot Ulcers Based on Stimulation of Myogenic Oscillations by Transient Ischemia","volume":"17","author":"Katarzynska","year":"2021","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.12669\/pjms.35.5.1421","article-title":"Strong association of anemia in people with diabetic foot ulcers (DFUs): Study from a specialist foot care center","volume":"35","author":"Shareef","year":"2019","journal-title":"Pak. J. Med Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2174\/1871530319666190111121913","article-title":"Anemia in Patients with Diabetic Foot Ulcer: Effects on Diabetic Microvascular Complications and Related Conditions","volume":"19","author":"Olgun","year":"2019","journal-title":"Endocrine Metab. Immune Disord. Drug Targets"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e025125","DOI":"10.1136\/bmjopen-2018-025125","article-title":"Anaemia among primary care patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD): A multicentred cross-sectional study","volume":"8","author":"Idris","year":"2018","journal-title":"BMJ Open"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.pcd.2017.04.002","article-title":"Anemia in diabetes: Experience of a single treatment center in Kuwait","volume":"11","author":"Alsayegh","year":"2017","journal-title":"Prim. Care Diabetes"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/104214","article-title":"Presence and Characterisation of Anaemia in Diabetic Foot Ulceration","volume":"2014","author":"Wright","year":"2014","journal-title":"Anemia"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejim.2009.12.002","article-title":"Anemia in diabetic patients at an internal medicine ward: Clinical correlates and prognostic significance","volume":"21","author":"Shteinshnaider","year":"2010","journal-title":"Eur. J. Intern. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/wrr.12902","article-title":"Is there an association between anemia and diabetic foot ulcers? A systematic review and meta-analysis","volume":"29","author":"Yammine","year":"2021","journal-title":"Wound Repair. Regen."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"S583","DOI":"10.1016\/j.dsx.2017.04.008","article-title":"Diabetic foot ulcer carries high amputation and mortality rates, particularly in the presence of advanced age, peripheral artery disease and anemia","volume":"11","author":"Costa","year":"2017","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/1534734616660224","article-title":"Anemia in Patients With Diabetic Foot Ulcer","volume":"15","author":"Chuan","year":"2016","journal-title":"Int. J. Low. Extremity Wounds"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2478\/enr-2020-0023","article-title":"Determinants of wound healing in patients hospitalized for diabetic foot ulcer: Results from the MEDFUN study","volume":"54","author":"Ezeani","year":"2020","journal-title":"Endocr. Regul."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Gezawa, I.D., Ugwu, E.T., Ezeani, I., Adeleye, O., Okpe, I., and Enamino, M. (2019). Anemia in patients with diabetic foot ulcer and its impact on disease outcome among Nigerians: Results from the MEDFUN study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0226226"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12893-021-01051-3","article-title":"Clinical profiles of diabetic foot ulcer patients undergoing major limb amputation at a tertiary care center in North-eastern Tanzania","volume":"21","author":"Shabhay","year":"2021","journal-title":"BMC Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5704\/MOJ.1911.008","article-title":"Predictive Factors of Major Lower Extremity Amputations in Diabetic Foot Infections: A Cross-sectional Study at District Hospital in Malaysia","volume":"13","author":"Ry","year":"2019","journal-title":"Malays. Orthop. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/ijem.IJEM_525_18","article-title":"Role of procalcitonin as a predictor of clinical outcome in acute diabetic foot infections: A prospective study","volume":"23","author":"Asirvatham","year":"2019","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1172\/JCI117919","article-title":"The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model","volume":"95","author":"Ghadially","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1001\/archderm.1991.04520010052006","article-title":"Skin aging. Effect on transepidermal water loss, stratum corneum hydration, skin surface pH, and casual sebum content","volume":"127","author":"Wilhelm","year":"1991","journal-title":"Arch. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/ijd.15417","article-title":"The stratum corneum water content and natural moisturization factor composition evolve with age and depend on body site","volume":"60","author":"Stamatas","year":"2021","journal-title":"Int. J. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e202100107","DOI":"10.1002\/jbio.202100107","article-title":"Raman confocal microscopy and biophysics multiparametric characterization of the skin barrier evolution with age","volume":"14","author":"Rigal","year":"2021","journal-title":"J. Biophotonics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/ced.14363","article-title":"Comparison of transepidermal water loss and skin hydration in diabetics and nondiabetics","volume":"46","author":"Lai","year":"2020","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2133.2005.06756.x","article-title":"Functional properties of the stratum corneum in patients with diabetes mellitus: Similarities to senile xerosis","volume":"153","author":"Sakai","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Ibuki, A., Kuriyama, S., Toyosaki, Y., Aiba, M., Hidaka, M., Horie, Y., Fujimoto, C., Isami, F., Shibata, E., and Terauchi, Y. (2018). Aging-like physiological changes in the skin of Japanese obese diabetic patients. SAGE Open Med., 6.","DOI":"10.1177\/2050312118756662"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e8611","DOI":"10.1097\/MD.0000000000008611","article-title":"Diabetic and sympathetic influences on the water permeability barrier function of human skin as measured using transepidermal water loss","volume":"96","author":"Han","year":"2017","journal-title":"Medicine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"474","DOI":"10.7150\/ijms.50764","article-title":"Differences in the mechanism of type 1 and type 2 diabetes-induced skin dryness by using model mice","volume":"18","author":"Horikawa","year":"2021","journal-title":"Int. J. Med Sci."},{"key":"ref_62","first-page":"173","article-title":"Influence of Peripheral Neuropathy and Microangiopathy on Skin Hydration in the Feet of Patients With Diabetes Mellitus","volume":"31","author":"Namgoong","year":"2019","journal-title":"Wounds"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"848e","DOI":"10.1097\/PRS.0000000000005474","article-title":"Skin Hydration Level as a Predictor for Diabetic Wound Healing","volume":"143","author":"Lee","year":"2019","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Okano, J., Kojima, H., Katagi, M., Nakagawa, T., Nakae, Y., Terashima, T., Kurakane, T., Kubota, M., Maegawa, H., and Udagawa, J. (2016). Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166215"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.immuni.2018.11.003","article-title":"Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta","volume":"50","author":"Zhang","year":"2018","journal-title":"Immunity"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1126\/science.1260972","article-title":"Dermal adipocytes protect against invasive Staphylococcus aureus skin infection","volume":"347","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/sj.jid.5701043","article-title":"In vitro and In vivo Wound Healing-Promoting Activities of Human Cathelicidin LL-37","volume":"128","author":"Carretero","year":"2008","journal-title":"J. Investig. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jdermsci.2011.09.013","article-title":"Expression of antimicrobial peptides in diabetic foot ulcer","volume":"65","author":"Trujillo","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.arcmed.2020.03.006","article-title":"Host Defense Peptide RNase 7 Is Down-regulated in the Skin of Diabetic Patients with or without Chronic Ulcers, and its Expression is Altered with Metformin","volume":"51","author":"Trujillo","year":"2020","journal-title":"Arch. Med Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Gonzalez, I., Trujillo, V., Montoya-Rosales, A.D.R., Rincon, K., Rivas-Calderon, B., Deharo-Acosta, J., Marin-Luevano, P., Lozano-Lopez, D., Enciso-Moreno, J.A., and Rivas-Santiago, B. (2014). 1,25-Dihydroxyvitamin D3 Induces LL-37 and HBD-2 Production in Keratinocytes from Diabetic Foot Ulcers Promoting Wound Healing: An In Vitro Model. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111355"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.actbio.2021.01.046","article-title":"A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes","volume":"124","author":"Wei","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1039\/C8BM00807H","article-title":"Antimicrobial peptide modification enhances the gene delivery and bactericidal efficiency of gold nanoparticles for accelerating diabetic wound healing","volume":"6","author":"Wang","year":"2018","journal-title":"Biomater. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.2147\/IJN.S190321","article-title":"Multiple cargo deliveries of growth factors and antimicrobial peptide using biodegradable nanopolymer as a potential wound healing system","volume":"ume 14","author":"Vijayan","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabres.2017.09.007","article-title":"Culture characterization of the skin microbiome in Type 2 diabetes mellitus: A focus on the role of innate immunity","volume":"134","author":"Jagadeesh","year":"2017","journal-title":"Diabetes Res. Clin. Pr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s12020-019-02103-8","article-title":"Comprehensive relationships between gut microbiome and faecal metabolome in individuals with type 2 diabetes and its complications","volume":"66","author":"Zhao","year":"2019","journal-title":"Endocrine"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"D\u00f6rr, S., Holland-Letz, A.-K., Weisser, G., Chatzitomaris, A., and Lobmann, R. (2021). Bacterial Diversity, Antibiotic Resistance, and the Risk of Lower Limb Amputation in Younger and Older Individuals With Diabetic Foot Infection. Int. J. Low. Extremity Wounds.","DOI":"10.1177\/1534734621992290"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41522-021-00202-x","article-title":"A multiomics approach to identify host-microbe alterations associated with infection severity in diabetic foot infections: A pilot study","volume":"7","author":"Radzieta","year":"2021","journal-title":"NPJ Biofilms Microbiomes"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fcimb.2018.00010","article-title":"Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection","volume":"8","author":"Sumitomo","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13047-019-0345-y","article-title":"Predictors of lower extremity amputation in patients with diabetic foot ulcer: Findings from MEDFUN, a multi-center observational study","volume":"12","author":"Ugwu","year":"2019","journal-title":"J. Foot Ankle Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1007\/s13346-017-0445-9","article-title":"Ciprofloxacin-loaded calcium alginate wafers prepared by freeze-drying technique for potential healing of chronic diabetic foot ulcers","volume":"8","author":"Ahmed","year":"2017","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/WON.0000000000000211","article-title":"Topical Therapy As Adjuvant Treatment to Save a Limb With Critical Ischemia From Extensive and Deep Diabetic Foot Infection When Revascularization Is Not Feasible","volume":"43","author":"Shen","year":"2016","journal-title":"J. Wound Ostomy Cont. Nurs."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2337\/diacare.16.4.560","article-title":"Skin Surface pH in Intertriginous Areas in NIDDM Patients: Possible Correlation to Candidal intertrigo","volume":"16","author":"Yosipovitch","year":"1993","journal-title":"Diabetes Care"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"59","DOI":"10.12968\/jowc.2005.14.2.26739","article-title":"Proteases and pH in chronic wounds","volume":"14","author":"Greener","year":"2005","journal-title":"J. Wound Care"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"6","DOI":"10.7547\/16-033","article-title":"Effects of pH on the Antibiotic Resistance of Bacteria Recovered from Diabetic Foot Ulcer Fluid","volume":"108","author":"McArdle","year":"2018","journal-title":"J. Am. Podiatr. Med Assoc."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/wound.2014.0608","article-title":"The Innate Immune System in Acute and Chronic Wounds","volume":"5","author":"MacLeod","year":"2016","journal-title":"Adv. Wound Care"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors Affecting Wound Healing","volume":"89","author":"Guo","year":"2010","journal-title":"J. Dent. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1524-475X.2007.00271.x","article-title":"Agent-based model of inflammation and wound healing: Insights into diabetic foot ulcer pathology and the role of transforming growth factor-\u03b21","volume":"15","author":"Mi","year":"2007","journal-title":"Wound Repair. Regen."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"265sr6","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: Mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1172\/JCI44490","article-title":"An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice","volume":"121","author":"Sindrilaru","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jvs.2008.11.049","article-title":"Inflammatory cytokine levels in chronic venous insufficiency ulcer tissue before and after compression therapy","volume":"49","author":"Beidler","year":"2009","journal-title":"J. Vasc. Surg."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1210\/jc.2008-2385","article-title":"Microvascular Reactivity and Inflammatory Cytokines in Painful and Painless Peripheral Diabetic Neuropathy","volume":"94","author":"Doupis","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Pastar, I., Nusbaum, A.G., Gil, J., Patel, S.B., Chen, J., Valdes, J., Stojadinovic, O., Plano, L.R., Tomic-Canic, M., and Davis, S.C. (2013). Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0056846"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/iwj.12557","article-title":"Reactive oxygen species (ROS) and wound healing: The functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process","volume":"14","author":"Dunnill","year":"2015","journal-title":"Int. Wound J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/j.1530-0277.2007.00386.x","article-title":"Matrix Proteolytic Activity During Wound Healing: Modulation by Acute Ethanol Exposure","volume":"31","author":"Radek","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_95","first-page":"e1461","article-title":"Acellular dermal matrix scaffolds coated with connective tissue growth factor accelerate diabetic wound healing by increasing fibronectin through PKC signalling pathway","volume":"12","author":"Yan","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/236238","article-title":"Topically Applied Connective Tissue Growth Factor\/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing","volume":"2015","author":"Henshaw","year":"2015","journal-title":"J. Diabetes Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/labinvest.2012.162","article-title":"A physiological role for connective tissue growth factor in early wound healing","volume":"93","author":"Alfaro","year":"2012","journal-title":"Lab. Investig."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.2337\/db12-0227","article-title":"Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration","volume":"61","author":"Dinh","year":"2012","journal-title":"Diabetes"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"15436","DOI":"10.18632\/aging.103610","article-title":"MicroRNA-21-3p accelerates diabetic wound healing in mice by downregulating SPRY1","volume":"12","author":"Wu","year":"2020","journal-title":"Aging"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1742-481X.2011.00890.x","article-title":"MicroRNA signature in diabetic wound healing: Promotive role of miR-21 in fibroblast migration","volume":"9","author":"Madhyastha","year":"2011","journal-title":"Int. Wound J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2147\/DMSO.S5859","article-title":"p38 MAPK inhibition reduces diabetes-induced impairment of wound healing","volume":"2","author":"Higgins","year":"2009","journal-title":"Diabetes Metab. Syndr. Obesity Targets Ther."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.freeradbiomed.2020.05.018","article-title":"Role of Nrf2 in MALAT1\/ HIF-1\u03b1 loop on the regulation of angiogenesis in diabetic foot ulcer","volume":"156","author":"Jayasuriya","year":"2020","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"12236","DOI":"10.18632\/aging.102562","article-title":"Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p","volume":"11","author":"Zhu","year":"2019","journal-title":"Aging"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.omtn.2019.05.020","article-title":"lncRNA MALAT1 Accelerates Wound Healing of Diabetic Mice Transfused with Modified Autologous Blood via the HIF-1\u03b1 Signaling Pathway","volume":"17","author":"Liu","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e000379","DOI":"10.1136\/bmjdrc-2016-000379","article-title":"Individuals with obesity and type 2 diabetes have additional immune dysfunction compared with obese individuals who are metabolically healthy","volume":"5","author":"Richard","year":"2017","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2337\/diab.23.1.9","article-title":"Impaired Leukocyte Function in Patients with Poorly Controlled Diabetes","volume":"23","author":"Bagdade","year":"1974","journal-title":"Diabetes"},{"key":"ref_107","first-page":"1","article-title":"The phagocytic activity of polymorphonuclear leukocytes obtained from patients with diabetes mellitus","volume":"64","author":"Bybee","year":"1964","journal-title":"J. Lab. Clin. Med."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Morey, M., O\u2019Gaora, P., Pandit, A., and H\u00e9lary, C. (2019). Hyperglycemia acts in synergy with hypoxia to maintain the pro-inflammatory phenotype of macrophages. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0220577"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/wrr.12752","article-title":"Human macrophage response to microbial supernatants from diabetic foot ulcers","volume":"27","author":"Deusenbery","year":"2019","journal-title":"Wound Repair. Regen."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11892-018-0970-z","article-title":"Dysfunctional Wound Healing in Diabetic Foot Ulcers: New Crossroads","volume":"18","author":"Davis","year":"2018","journal-title":"Curr. Diabetes Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/path.4548","article-title":"Macrophage PPAR\u03b3 and impaired wound healing in type 2 diabetes","volume":"236","author":"Mirza","year":"2015","journal-title":"J. Pathol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Montanaro, M., Meloni, M., Anemona, L., Giurato, L., Scimeca, M., Izzo, V., Servadei, F., Smirnov, A., Candi, E., and Mauriello, A. (2020). Macrophage Activation and M2 Polarization in Wound Bed of Diabetic Patients Treated by Dermal\/Epidermal Substitute Nevelia. Int. J. Low. Extremity Wounds.","DOI":"10.1177\/1534734620945559"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1089\/wound.2012.0407","article-title":"Disclosure of the Culprits: Macrophages\u2014Versatile Regulators of Wound Healing","volume":"2","author":"Sindrilaru","year":"2013","journal-title":"Adv. Wound Care"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jid.2018.10.039","article-title":"Role of Chemokine Receptor CCR4 and Regulatory T Cells in Wound Healing of Diabetic Mice","volume":"139","author":"Barros","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/cmi.2015.116","article-title":"Impaired T-cell differentiation in diabetic foot ulceration","volume":"14","author":"Moura","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"ref_116","first-page":"e15900","article-title":"Analysis of T Cell Receptor V\u03b2 Diversity in Peripheral CD4+ and CD8+ T Lymphocytes Obtained From Patients With Chronic Severe Hepatitis B","volume":"14","author":"Xiong","year":"2014","journal-title":"Zahedan J. Res. Med Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1128\/CDLI.10.1.53-58.2003","article-title":"Alterations in T-Cell Receptor V\u03b2 Repertoire of CD4 and CD8 T Lymphocytes in Human Immunodeficiency Virus-Infected Children","volume":"10","author":"Kharbanda","year":"2003","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.2337\/dc08-2318","article-title":"Immune Mediators in Patients With Acute Diabetic Foot Syndrome","volume":"32","author":"Weigelt","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jinf.2007.06.003","article-title":"Phagocytic activity of neutrophils improves over the course of therapy of diabetic foot infections","volume":"55","author":"Top","year":"2007","journal-title":"J. Infect."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jinf.2006.05.004","article-title":"Effect of the function of polymorphonuclear leukocytes and interleukin-1 beta on wound healing in patients with diabetic foot infections","volume":"54","author":"Oncul","year":"2007","journal-title":"J. Infect."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.metabol.2006.02.007","article-title":"Effect of acute hyperglycemia and\/or hyperinsulinemia on polymorphonuclear functions in healthy subjects","volume":"55","author":"Kalanin","year":"2006","journal-title":"Metabolism"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2147\/DMSO.S284583","article-title":"Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Predict Mortality in Patients with Diabetic Foot Ulcers Undergoing Amputations","volume":"14","author":"Chen","year":"2021","journal-title":"Diabetes Metab. Syndr. Obesity Targets Ther."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/1534734617696729","article-title":"Comparison of the Neutrophil\/Lymphocyte Ratio and C-Reactive Protein Levels in Patients With Amputation for Diabetic Foot Ulcers","volume":"16","author":"Metineren","year":"2017","journal-title":"Int. J. Low. Extremity Wounds"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1365-2141.2004.05357.x","article-title":"Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia","volume":"128","author":"Kaito","year":"2005","journal-title":"Br. J. Haematol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/j.1538-7836.2004.00836.x","article-title":"Platelet activation in type 2 diabetes mellitus","volume":"2","author":"Ferroni","year":"2004","journal-title":"J. Thromb. Haemost."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1196\/annals.1372.016","article-title":"Diabetic Patients: Psychological Aspects","volume":"1084","author":"Adili","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13047-019-0367-5","article-title":"Associations of foot ulceration with quality of life and psychosocial determinants among patients with diabetes; a case-control study","volume":"12","author":"Alosaimi","year":"2019","journal-title":"J. Foot Ankle Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s11136-018-2082-2","article-title":"Health-related quality of life among adults living with diabetic foot ulcers: A meta-analysis","volume":"28","author":"Khunkaew","year":"2018","journal-title":"Qual. Life Res."},{"key":"ref_129","first-page":"1","article-title":"Does the Diabetic Foot Have a Significant Impact on Selected Psychological or Social Characteristics of Patients with Diabetes Mellitus?","volume":"2014","author":"Dragomirecka","year":"2014","journal-title":"J. Diabetes Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e3257","DOI":"10.1002\/dmrr.3257","article-title":"Psychosocial research in the diabetic foot: Are we making progress?","volume":"36","author":"Vileikyte","year":"2019","journal-title":"Diabetes\/Metabolism Res. Rev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1023\/A:1008836325782","article-title":"Quality of life issues in patients with diabetes and lower extremity ulcers: Patients and care givers","volume":"7","author":"Brod","year":"1998","journal-title":"Qual. Life Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.2337\/diacare.26.9.2549","article-title":"The Development and Validation of a Neuropathy- and Foot Ulcer-Specific Quality of Life Instrument","volume":"26","author":"Vileikyte","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1056-8727(00)00133-1","article-title":"Health-related quality of life in patients with diabetes mellitus and foot ulcers","volume":"14","author":"Tennvall","year":"2000","journal-title":"J. Diabetes Its Complicat."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/1534734617704083","article-title":"Improved Quality of Life After Transtibial Amputation in Patients with Diabetes-Related Foot Complications","volume":"16","author":"Wukich","year":"2017","journal-title":"Int. J. Low. Extremity Wounds"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e18480","DOI":"10.1097\/MD.0000000000018480","article-title":"The effect of an intensive patients\u2019 education program on anxiety, depression and patient global assessment in diabetic foot ulcer patients with Wagner grade 1\/2","volume":"99","author":"Chen","year":"2020","journal-title":"Medicine"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1464-5491.2007.02370.x","article-title":"Psychotherapy intervention to reduce depressive symptoms in patients with diabetic foot syndrome","volume":"25","author":"Simson","year":"2008","journal-title":"Diabet. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"37S","DOI":"10.1016\/j.jvs.2015.10.002","article-title":"A systematic review and meta-analysis of d\u00e9bridement methods for chronic diabetic foot ulcers","volume":"63","author":"Elraiyah","year":"2016","journal-title":"J. Vasc. Surg."},{"key":"ref_138","first-page":"409","article-title":"Autolytic debridement and management of bacterial load with an occlusive hydroactive deressing impregnated with polyhexamethylene biguanide","volume":"88","author":"Mancini","year":"2018","journal-title":"Acta Biomed."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"160","DOI":"10.12968\/jowc.2016.25.3.160","article-title":"Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: A single-blind RCT","volume":"25","author":"Bellingeri","year":"2016","journal-title":"J. Wound Care"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/iwj.12734","article-title":"Effectiveness of a polyhexanide irrigation solution on methicillin-resistant Staphylococcus aureus biofilms in a porcine wound model","volume":"14","author":"Davis","year":"2017","journal-title":"Int. Wound J."},{"key":"ref_141","first-page":"283","article-title":"Evaluation of the effectiveness of a polyhexanide and propyl betaine-based gel in the treatment of chronic wounds","volume":"69","author":"Durante","year":"2014","journal-title":"Minerva Chir."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2217\/cer-2020-0058","article-title":"Type I collagen matrix plus polyhexamethylene biguanide antimicrobial for the treatment of cutaneous wounds","volume":"9","author":"Koullias","year":"2020","journal-title":"J. Comp. Eff. Res."},{"key":"ref_143","first-page":"494","article-title":"Evaluation of short exposure times of antimicrobial wound solutions against microbial biofilms: From in vitro to in vivo","volume":"73","author":"Aljohani","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1053\/j.jfas.2018.05.011","article-title":"Efficacy of Hyperbaric Oxygen Therapy in Diabetic Foot Ulcers Based on Wagner Classification","volume":"57","year":"2018","journal-title":"J. Foot Ankle Surg."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/6425857","article-title":"A Pilot Study of Short-Duration Hyperbaric Oxygen Therapy to Improve HbA1c, Leukocyte, and Serum Creatinine in Patients with Diabetic Foot Ulcer Wagner 3-4","volume":"2018","author":"Irawan","year":"2018","journal-title":"Sci. World J."},{"key":"ref_146","first-page":"31","article-title":"The effect of hyperbaric oxygen therapy on gene expression: Microarray analysis on wound healing","volume":"47","author":"Oniscenko","year":"2020","journal-title":"Undersea Hyperb. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/wrr.12782","article-title":"Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase-9","volume":"28","author":"Nguyen","year":"2019","journal-title":"Wound Repair. Regen."},{"key":"ref_148","first-page":"35","article-title":"Modification of HIF-1\u03b1, NF-\u03baB, IGFBP-3, VEGF and adiponectin in diabetic foot ulcers treated with hyperbaric oxygen","volume":"46","year":"2019","journal-title":"Undersea Hyperb. Med."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Baiula, M., Greco, R., Ferrazzano, L., Caligiana, A., Hoxha, K., Bandini, D., Longobardi, P., Spampinato, S., and Tolomelli, A. (2020). Integrin-mediated adhesive properties of neutrophils are reduced by hyperbaric oxygen therapy in patients with chronic non-healing wound. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0237746"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/WON.0000000000000374","article-title":"Adjunctive Hyperbaric Oxygen Therapy for Healing of Chronic Diabetic Foot Ulcers","volume":"44","author":"Chen","year":"2017","journal-title":"J. Wound Ostomy Cont. Nurs."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.2337\/diacare.23.10.1551","article-title":"Systemic hyperbaric oxygen therapy: Lower-extremity wound healing and the diabetic foot","volume":"23","author":"Wunderlich","year":"2000","journal-title":"Diabetes Care"},{"key":"ref_152","first-page":"81","article-title":"Topical Oxygen Therapy Shifts Microbiome Dynamics in Chronic Diabetic Foot Ulcers","volume":"32","author":"Hunter","year":"2020","journal-title":"Wounds"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"652","DOI":"10.12968\/jowc.2017.26.11.652","article-title":"Topical oxygen therapy promotes the healing of chronic diabetic foot ulcers: A pilot study","volume":"26","author":"Hayes","year":"2017","journal-title":"J. Wound Care"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e026345","DOI":"10.1136\/bmjopen-2018-026345","article-title":"Negative pressure wound therapy compared with standard moist wound care on diabetic foot ulcers in real-life clinical practice: Results of the German DiaFu-RCT","volume":"10","author":"Seidel","year":"2020","journal-title":"BMJ Open"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1524-475X.2010.00658.x","article-title":"Comparison of negative pressure wound therapy with an ultraportable mechanically powered device vs. traditional electrically powered device for the treatment of chronic lower extremity ulcers: A multicenter randomized-controlled trial","volume":"19","author":"Armstrong","year":"2011","journal-title":"Wound Repair. Regen."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s00268-016-3782-9","article-title":"Handcrafted Vacuum-Assisted Device for Skin Ulcers Treatment Versus Traditional Therapy, Randomized Controlled Trial","volume":"41","author":"Gonzalez","year":"2016","journal-title":"World J. Surg."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.athoracsur.2004.10.053","article-title":"Blood Flow Responses in the Peristernal Thoracic Wall During Vacuum-Assisted Closure Therapy","volume":"79","author":"Wackenfors","year":"2005","journal-title":"Ann. Thorac. Surg."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/PRS.0b013e31829f4ad9","article-title":"Does a Zone of Increased Perfusion Exist around Negative-Pressure Dressings?","volume":"132","author":"Kairinos","year":"2013","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/01.ASW.0000483038.18331.a4","article-title":"Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in Diabetic Feet","volume":"29","author":"Jung","year":"2016","journal-title":"Adv. Ski. Wound Care"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13047-017-0244-z","article-title":"Diabetic Foot Australia guideline on footwear for people with diabetes","volume":"11","author":"Lazzarini","year":"2018","journal-title":"J. Foot Ankle Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"e00132","DOI":"10.1002\/edm2.132","article-title":"Footwear and insole design features for offloading the diabetic at risk foot\u2014A systematic review and meta-analyses","volume":"4","author":"Collings","year":"2020","journal-title":"Endocrinol. Diabetes Metab."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jcot.2021.01.005","article-title":"Surgical OFF-LOADING of the diabetic foot","volume":"16","author":"Paola","year":"2021","journal-title":"J. Clin. Orthop. Trauma"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Ahluwalia, R., Maffulli, N., L\u00e1zaro-Mart\u00ednez, J.L., Kirketerp-M\u00f8ller, K., and Reichert, I. (2021). Diabetic foot off loading and ulcer remission: Exploring surgical off-loading. Surgeon.","DOI":"10.1016\/j.surge.2021.01.005"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Yammine, K., and Assi, C. (2020). Surgery Versus Nonsurgical Methods in Treating Neuropathic Plantar Forefoot Ulcers: A Meta-Analysis of Comparative Studies. Int. J. Low. Extremity Wounds.","DOI":"10.2139\/ssrn.3327358"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/00129334-200506000-00012","article-title":"Randomized Clinical Trial Comparing OASIS Wound Matrix to Regranex Gel for Diabetic Ulcers","volume":"18","author":"Niezgoda","year":"2005","journal-title":"Adv. Ski. Wound Care"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1517\/14712598.2.2.211","article-title":"Becaplermin: Recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers","volume":"2","author":"Embil","year":"2002","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"48S","DOI":"10.1016\/S0002-9610(98)00177-9","article-title":"Preclinical promise of becaplermin (rhPDGF-BB) in wound healing","volume":"176","author":"LeGrand","year":"1998","journal-title":"Am. J. Surg."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"db18-0699","DOI":"10.2337\/db18-0699","article-title":"Potential of Allogeneic Adipose-Derived Stem Cell\u2014 Hydrogel Complex for Treating Diabetic Foot Ulcers","volume":"68","author":"Moon","year":"2019","journal-title":"Diabetes"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Bai, H., Kyu-Cheol, N., Wang, Z., Cui, Y., Liu, H., Liu, H., Feng, Y., Zhao, Y., Lin, Q., and Li, Z. (2020). Regulation of inflammatory microenvironment using a self-healing hydrogel loaded with BM-MSCs for advanced wound healing in rat diabetic foot ulcers. J. Tissue Eng., 11.","DOI":"10.1177\/2041731420947242"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.jid.2017.02.976","article-title":"Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing","volume":"137","author":"Santos","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1021\/acsbiomaterials.0c01502","article-title":"Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing","volume":"7","author":"Ding","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/iwj.13353","article-title":"An observational pilot study using a purified reconstituted bilayer matrix to treat non-healing diabetic foot ulcers","volume":"17","author":"Armstrong","year":"2020","journal-title":"Int. Wound J."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/wrr.12551","article-title":"A randomized clinical trial of a human acellular dermal matrix demonstrated superior healing rates for chronic diabetic foot ulcers over conventional care and an active acellular dermal matrix comparator","volume":"25","author":"Cazzell","year":"2017","journal-title":"Wound Repair. Regen."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s13304-017-0461-9","article-title":"To evaluate the efficacy of an acellular Flowable matrix in comparison with a wet dressing for the treatment of patients with diabetic foot ulcers: A randomized clinical trial","volume":"69","author":"Campitiello","year":"2017","journal-title":"Updat. Surg."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-019-1415-6","article-title":"Stromal vascular fraction promotes migration of fibroblasts and angiogenesis through regulation of extracellular matrix in the skin wound healing process","volume":"10","author":"Bi","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e11667","DOI":"10.1097\/MD.0000000000011667","article-title":"Treatment of human chronic wounds with autologous extracellular matrix\/stromal vascular fraction gel","volume":"97","author":"Deng","year":"2018","journal-title":"Medicine"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S2213-8587(17)30438-2","article-title":"Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): An international, multicentre, double-blind, randomised, controlled trial","volume":"6","author":"Edmonds","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"L\u00e1zaro-Mart\u00ednez, J.L., Garc\u00eda-Madrid, M., Garc\u00eda-Alamino, J.M., Bohbot, S., Garc\u00eda-Klepzig, J.L., and Garc\u00eda-\u00c1lvarez, Y. (2020). Increasing Transcutaneous Oxygen Pressure in Patients With Neuroischemic Diabetic Foot Ulcers Treated With a Sucrose Octasulfate Dressing: A Pilot Study. Int. J. Low. Extremity Wounds.","DOI":"10.1177\/1534734620952244"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"543","DOI":"10.12968\/jowc.2020.29.10.543","article-title":"Impact of wound duration on diabetic foot ulcer healing: Evaluation of a new sucrose octasulfate wound dressing","volume":"29","author":"Lobmann","year":"2020","journal-title":"J. Wound Care"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Laiva, A., O\u2019Brien, F., and Keogh, M. (2021). SDF-1\u03b1 Gene-Activated Collagen Scaffold Restores Pro-Angiogenic Wound Healing Features in Human Diabetic Adipose-Derived Stem Cells. Biomedicines, 9.","DOI":"10.3390\/biomedicines9020160"},{"key":"ref_181","first-page":"1","article-title":"c-Jun Overexpression Accelerates Wound Healing in Diabetic Rats by Human Umbilical Cord-Derived Mesenchymal Stem Cells","volume":"2020","author":"Yue","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_182","first-page":"1","article-title":"Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db\/db mice","volume":"11","author":"Contador","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.dsx.2018.11.032","article-title":"Topic platelet gel application in chronic diabetic foot ulcers","volume":"13","author":"Antunes","year":"2018","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1053\/j.semvascsurg.2017.12.001","article-title":"Efficacy of cord blood platelet gel application for enhancing diabetic foot ulcer healing after lower limb revascularization","volume":"30","author":"Volpe","year":"2017","journal-title":"Semin. Vasc. Surg."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4239\/wjd.v9.i10.172","article-title":"Topical application of platelet-rich plasma for diabetic foot ulcers: A systematic review","volume":"9","author":"Hirase","year":"2018","journal-title":"World J. Diabetes"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"784","DOI":"10.12968\/jowc.2017.26.12.784","article-title":"Management of chronic diabetic foot ulcers using platelet-rich plasma","volume":"26","author":"Babaei","year":"2017","journal-title":"J. Wound Care"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.avsg.2016.04.023","article-title":"Platelet-Rich Plasma for the Treatment of Clean Diabetic Foot Ulcers","volume":"38","author":"Ahmed","year":"2017","journal-title":"Ann. Vasc. Surg."},{"key":"ref_188","first-page":"333","article-title":"Platelet gel: A new therapeutic tool with great potential","volume":"15","author":"Piccin","year":"2016","journal-title":"Blood Transf."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/wrr.12294","article-title":"Autologous platelet-rich gel for treatment of diabetic chronic refractory cutaneous ulcers: A prospective, randomized clinical trial","volume":"23","author":"Li","year":"2015","journal-title":"Wound Repair. Regen."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3109\/09537104.2012.684730","article-title":"The role of platelet-rich plasma in tissue regeneration","volume":"24","author":"Alsousou","year":"2012","journal-title":"Platelets"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"He, M., Guo, X., Li, T., Jiang, X., Chen, Y., Yuan, Y., Chen, B., Yang, G., Fan, Y., and Liang, Z. (2020). Comparison of Allogeneic Platelet-rich Plasma With Autologous Platelet-rich Plasma for the Treatment of Diabetic Lower Extremity Ulcers. Cell Transplant., 29.","DOI":"10.1177\/0963689720931428"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jss.2019.09.019","article-title":"Allogeneic Platelet-Rich Plasma Therapy as an Effective and Safe Adjuvant Method for Chronic Wounds","volume":"246","author":"Liao","year":"2019","journal-title":"J. Surg. Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tibtech.2016.11.001","article-title":"Allogeneic Platelet-Rich Plasma: At the Dawn of an Off-the-Shelf Therapy?","volume":"35","author":"Anitua","year":"2016","journal-title":"Trends Biotechnol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"15","DOI":"10.12968\/jowc.2019.28.1.15","article-title":"Use of platelet-rich plasma and platelet-derived patches to treat chronic wounds","volume":"28","author":"Tsai","year":"2019","journal-title":"J. Wound Care"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/PRS.0b013e3181cb6589","article-title":"Treatment of Diabetic Foot Ulcers Using a Blood Bank Platelet Concentrate","volume":"125","author":"Jeong","year":"2010","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1007\/s00268-019-05316-0","article-title":"Randomized Controlled Trial on Autologous Platelet-Rich Plasma Versus Saline Dressing in Treatment of Non-healing Diabetic Foot Ulcers","volume":"44","author":"Elsaid","year":"2019","journal-title":"World J. Surg."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.21037\/atm.2018.12.44","article-title":"Management of hard-to-heal diabetic foot ulcers: Local use of autologous leucocytes, platelets and fibrin multi-layered patches (LeucoPatch)","volume":"6","author":"Afonso","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S2213-8587(18)30240-7","article-title":"LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: An observer-masked, randomised controlled trial","volume":"6","author":"Game","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/s13063-017-2216-9","article-title":"The LeucoPatch\u00ae system in the management of hard-to-heal diabetic foot ulcers: Study protocol for a randomised controlled trial","volume":"18","author":"Game","year":"2017","journal-title":"Trials"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.reth.2017.02.002","article-title":"Xenogeneic transplantation of human adipose-derived stem cell sheets accelerate angiogenesis and the healing of skin wounds in a Zucker Diabetic Fatty rat model of obese diabetes","volume":"6","author":"Hamada","year":"2017","journal-title":"Regen. Ther."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/abbs\/gmaa039","article-title":"Role and effect of vein-transplanted human umbilical cord mesenchymal stem cells in the repair of diabetic foot ulcers in rats","volume":"52","author":"Shi","year":"2020","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"115734","DOI":"10.1016\/j.carbpol.2019.115734","article-title":"A new waterborne chitosan-based polyurethane hydrogel as a vehicle to transplant bone marrow mesenchymal cells improved wound healing of ulcers in a diabetic rat model","volume":"231","author":"Viezzer","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.2217\/rme-2019-0086","article-title":"Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing","volume":"15","author":"Gorecka","year":"2020","journal-title":"Regen. Med."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02454-y","article-title":"Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway","volume":"12","author":"Ebrahim","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/sctm.19-0380","article-title":"Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice","volume":"9","author":"Yang","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1177\/0963689719835177","article-title":"Long-Term Outcomes of BMMSC Compared with BMMNC for Treatment of Critical Limb Ischemia and Foot Ulcer in Patients with Diabetes","volume":"28","author":"Lu","year":"2019","journal-title":"Cell Transplant."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1089\/scd.2021.0100","article-title":"Human Exosomes Accelerate Cutaneous Wound Healing by Promoting Collagen Synthesis in a Diabetic Mouse Model","volume":"30","author":"Zhao","year":"2021","journal-title":"Stem Cells Dev."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"102235","DOI":"10.1016\/j.scr.2021.102235","article-title":"Human mesenchymal stem cells promote ischemic repairment and angiogenesis of diabetic foot through exosome miRNA-21-5p","volume":"52","author":"Huang","year":"2021","journal-title":"Stem Cell Res."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.2147\/IJN.S249129","article-title":"Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes Combined Pluronic F127 Hydrogel Promote Chronic Diabetic Wound Healing and Complete Skin Regeneration","volume":"15","author":"Yang","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"L\u00e1zaro-Mart\u00ednez, J., \u00c1lvaro-Afonso, F., Sevillano-Fern\u00e1ndez, D., Garc\u00eda-\u00c1lvarez, Y., Sanz-Corbalan, I., and Garc\u00eda-Morales, E. (2020). Cellular Proliferation, Dermal Repair, and Microbiological Effectiveness of Ultrasound-Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU): An Open-Label Randomized Controlled Trial. J. Clin. Med., 9.","DOI":"10.3390\/jcm9124032"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4066\/AMJ.2015.2422","article-title":"Spectrum of bacteria associated with diabetic foot ulcer and biofilm formation: A prospective study","volume":"8","author":"Banu","year":"2015","journal-title":"Australas. Med. J."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/nyas.13569","article-title":"Update on management of diabetic foot ulcers","volume":"1411","author":"Everett","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/wrr.12391","article-title":"WHS guidelines update: Diabetic foot ulcer treatment guidelines","volume":"24","author":"Lavery","year":"2016","journal-title":"Wound Repair. Regen."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1524-475X.2006.00176.x","article-title":"Guidelines for the treatment of diabetic ulcers","volume":"14","author":"Steed","year":"2006","journal-title":"Wound Repair. Regen."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/2000656X.2019.1673170","article-title":"Clinical experience with surgical debridement and simultaneous meshed skin grafts in treating biofilm-associated infection: An exploratory retrospective pilot study","volume":"54","author":"Namgoong","year":"2019","journal-title":"J. Plast. Surg. Hand Surg."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1524-475X.2010.00619.x","article-title":"The role of surgical debridement in healing of diabetic foot ulcers","volume":"18","author":"Lebrun","year":"2010","journal-title":"Wound Repair. Regen."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Fernando, M.E., Crowther, R.G., Pappas, E., Lazzarini, P.A., Cunningham, M., Sangla, K.S., Buttner, P., and Golledge, J. (2014). Plantar Pressure in Diabetic Peripheral Neuropathy Patients with Active Foot Ulceration, Previous Ulceration and No History of Ulceration: A Meta-Analysis of Observational Studies. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0099050"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Fernando, M.E., Crowther, R.G., Lazzarini, P.A., Yogakanthi, S., Sangla, K.S., Buttner, P., Jones, R., and Golledge, J. (2017). Plantar pressures are elevated in people with longstanding diabetes-related foot ulcers during follow-up. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0181916"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1089\/wound.2011.0326","article-title":"Epidermal Growth Factor and Epidermal Growth Factor Receptor: The Yin and Yang in the Treatment of Cutaneous Wounds and Cancer","volume":"2","author":"Bodnar","year":"2013","journal-title":"Adv. Wound Care"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1524-475X.1999.00172.x","article-title":"In vivo characterization of keratinocyte growth factor-2 as a potential wound healing agent","volume":"7","author":"Soler","year":"1999","journal-title":"Wound Repair. Regen."},{"key":"ref_221","first-page":"1375","article-title":"Platelet-derived growth factor (BB homodimer), transforming growth factor-beta 1, and basic fibroblast growth factor in dermal wound healing. Neovessel and matrix formation and cessation of repair","volume":"140","author":"Pierce","year":"1992","journal-title":"Am. J. Pathol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1089\/wound.2012.0370","article-title":"Proteases and Delayed Wound Healing","volume":"2","author":"Mccarty","year":"2013","journal-title":"Adv. Wound Care"},{"key":"ref_223","first-page":"1","article-title":"Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome","volume":"2017","year":"2017","journal-title":"BioMed Res. Int."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/bdd.299","article-title":"Disposition and receptor-site binding of125I-EGF after topical administration to skin wounds","volume":"23","author":"Prats","year":"2002","journal-title":"Biopharm. Drug Dispos."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00006534-199508000-00001","article-title":"Topical Application of Epidermal Growth Factor onto Partial-Thickness Wounds in Human Volunteers Does Not Enhance Reepithelialization","volume":"96","author":"Cohen","year":"1995","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1524-4725.1992.tb03514.x","article-title":"Topical Use of Human Recombinant Epidermal Growth Factor (h-EGF) in Venous Ulcers","volume":"18","author":"Falanga","year":"1992","journal-title":"J. Dermatol. Surg. Oncol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2119\/2006-00054.Brem","article-title":"Molecular Markers in Patients with Chronic Wounds to Guide Surgical Debridement","volume":"13","author":"Brem","year":"2007","journal-title":"Mol. Med."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1046\/j.1524-475X.1997.50106.x","article-title":"The role of growth factors in the healing of chronic wounds","volume":"5","author":"Robson","year":"1997","journal-title":"Wound Repair. Regen."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1524-475X.1996.40404.x","article-title":"Interactions of cytokines, growth factors, and proteases in acute and chronic wounds","volume":"4","author":"Mast","year":"1996","journal-title":"Wound Repair. Regen."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-021-02298-5","article-title":"Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds","volume":"4","author":"Jozic","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"e129320","DOI":"10.1172\/jci.insight.129320","article-title":"Mevastatin promotes healing by targeting caveolin-1 to restore EGFR signaling","volume":"4","author":"Sawaya","year":"2019","journal-title":"JCI Insight"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.ymthe.2019.07.016","article-title":"Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure","volume":"27","author":"Jozic","year":"2019","journal-title":"Mol. Ther."},{"key":"ref_233","unstructured":"Snyder, D., Sullivan, N., Margolis, D., and Schoelles, K. (2020). Skin Substitutes for Treating Chronic Wounds."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1097\/SAP.0000000000002096","article-title":"Evidence for Healing Diabetic Foot Ulcers With Biologic Skin Substitutes","volume":"83","author":"Gordon","year":"2019","journal-title":"Ann. Plast. Surg."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/wrr.12434","article-title":"Systematic review and meta-analysis of skin substitutes in the treatment of diabetic foot ulcers: Highlights of a Cochrane systematic review","volume":"24","author":"Santema","year":"2016","journal-title":"Wound Repair. Regen."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"73","DOI":"10.7547\/1000073","article-title":"Confirmatory Data from EU Study Supports Apligraf for the Treatment of Neuropathic Diabetic Foot Ulcers","volume":"100","author":"Steinberg","year":"2010","journal-title":"J. Am. Podiatr. Med Assoc."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jdiacomp.2007.03.006","article-title":"Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcers. A prospective randomized trial","volume":"21","author":"Kakagia","year":"2007","journal-title":"J. Diabetes Its Complicat."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-01967-2","article-title":"Transplantation of photobiomodulation-preconditioned diabetic stem cells accelerates ischemic wound healing in diabetic rats","volume":"11","author":"Ahmadi","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-019-1328-4","article-title":"Autologous micro-fragmented adipose tissue for the treatment of diabetic foot minor amputations: A randomized controlled single-center clinical trial (MiFrAADiF)","volume":"10","author":"Lonardi","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8820538","article-title":"Combined Transplantation of Mesenchymal Stem Cells and Endothelial Colony-Forming Cells Accelerates Refractory Diabetic Foot Ulcer Healing","volume":"2020","author":"Zhao","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/6748530","article-title":"Treatment of Diabetic Foot with Autologous Stem Cells: A Meta-Analysis of Randomized Studies","volume":"2020","author":"Dai","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/exd.12104","article-title":"Quality assessment of tissue specimens for studies of diabetic foot ulcers","volume":"22","author":"Stojadinovic","year":"2013","journal-title":"Exp. Dermatol."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Dpm, P.A.C., Davis, K.E., Ahn, J., Farrar, D., van Asten, S., La Fontaine, J., and Lavery, L.A. (2020). The infected diabetic foot: Can serum biomarkers predict osteomyelitis after hospital discharge for diabetic foot infections?. Wound Repair. Regen., 28.","DOI":"10.1111\/wrr.12836"},{"key":"ref_244","first-page":"40","article-title":"The value of inflammatory markers to diagnose and monitor diabetic foot osteomyelitis","volume":"14","author":"Nichols","year":"2015","journal-title":"Int. Wound J."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/4312737","article-title":"Procalcitonin Is a Prognostic Marker of Hospital Outcomes in Patients with Critical Limb Ischemia and Diabetic Foot Infection","volume":"2019","author":"Meloni","year":"2019","journal-title":"J. Diabetes Res."},{"key":"ref_246","first-page":"37","article-title":"Pro-Calcitonin, Erythrocyte Sedimentation Rate and C-reactive Protein in Predicting Diabetic Foot Ulcer Characteristics; a Cross Sectional Study","volume":"7","author":"Hadavand","year":"2019","journal-title":"Arch. Acad. Emerg. Med."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1053\/j.jfas.2017.01.014","article-title":"Procalcitonin as a Biomarker for Predicting Amputation Level in Lower Extremity Infections","volume":"56","author":"Reiner","year":"2017","journal-title":"J. Foot Ankle Surg."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/7104352","article-title":"The Role of Serum Procalcitonin, Interleukin-6, and Fibrinogen Levels in Differential Diagnosis of Diabetic Foot Ulcer Infection","volume":"2018","author":"Korkmaz","year":"2018","journal-title":"J. Diabetes Res."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1097\/CORR.0000000000000718","article-title":"What are the Optimal Cutoff Values for ESR and CRP to Diagnose Osteomyelitis in Patients with Diabetes-related Foot Infections?","volume":"477","author":"Lavery","year":"2019","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_250","first-page":"77","article-title":"Is Procalcitonin more superior to hs-CRP in the diagnosis of infection in diabetic foot ulcer?","volume":"42","author":"Zakariah","year":"2020","journal-title":"Malays. J. Pathol."},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Ryan, E., Ahn, J., Wukich, D.K., La Fontaine, J., A Crisologo, P., Malone, M., Oz, O., and A Lavery, L. (2020). Presence of Sensory Neuropathy Modifies the Predictive Value of Inflammatory Biomarkers for Osteomyelitis in Diabetic and Non-Diabetic Patients with Foot Infections. J. Am. Podiatr. Med Assoc.","DOI":"10.7547\/20-168"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1007\/s00125-017-4417-x","article-title":"Application of white blood cell SPECT\/CT to predict remission after a 6 or 12 week course of antibiotic treatment for diabetic foot osteomyelitis","volume":"60","author":"Vouillarmet","year":"2017","journal-title":"Diabetologia"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/MNM.0000000000001390","article-title":"99mTc-white blood cell SPECT\/CT to assess diabetic foot osteomyelitis remission: Contribution of semi-quantitative scoring system","volume":"42","author":"Vouillarmet","year":"2021","journal-title":"Nucl. Med. Commun."},{"key":"ref_254","first-page":"1","article-title":"ENA-78 Is a Novel Predictor of Wound Healing in Patients with Diabetic Foot Ulcers","volume":"2019","author":"Li","year":"2019","journal-title":"J. Diabetes Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2217\/bmm-2018-0339","article-title":"Wound exudate CXCL6: A potential biomarker for wound healing of diabetic foot ulcers","volume":"13","author":"Wang","year":"2019","journal-title":"Biomarkers Med."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/1631325","article-title":"Wound Fluid Matrix Metalloproteinase-9 as a Potential Predictive Marker for the Poor Healing Outcome in Diabetic Foot Ulcers","volume":"2018","author":"Jindatanmanusan","year":"2018","journal-title":"Pathol. Res. Int."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/WON.0000000000000780","article-title":"Biomarker Prediction of Postoperative Healing of Diabetic Foot Ulcers","volume":"48","author":"Cheng","year":"2021","journal-title":"J. Wound Ostomy Cont. Nurs."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"127","DOI":"10.5152\/j.aott.2020.02.518","article-title":"The role of the platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in the prediction of length and cost of hospital stay in patients with infected diabetic foot ulcers: A retrospective comparative study","volume":"54","author":"Eren","year":"2020","journal-title":"Acta Orthop. Traumatol. Turc."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-020-00657-7","article-title":"Angiopoietin-like 2 is a potential biomarker for diabetic foot patients","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Endocr. Disord."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Chen, T., Yu, J., Wang, J., Chang, Q., and Qian, C. (2020). Elevated Serum Levels of Lp-PLA2 and IL-18 are Associated with Progression of Diabetic Foot Ulcers. Clin. Lab., 66.","DOI":"10.7754\/Clin.Lab.2020.191253"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/iwj.13075","article-title":"Pentraxin-3: A new parameter in predicting the severity of diabetic foot infection?","volume":"16","author":"Balin","year":"2019","journal-title":"Int. Wound J."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/s41423-019-0233-1","article-title":"Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration","volume":"16","author":"Moura","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2337\/db15-0517","article-title":"Measurements of CD34+\/CD45-dim Stem Cells Predict Healing of Diabetic Neuropathic Wounds","volume":"65","author":"Thom","year":"2015","journal-title":"Diabetes"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1089\/wound.2019.0943","article-title":"Neutrophil Extracellular Traps Are Markers of Wound Healing Impairment in Patients with Diabetic Foot Ulcers Treated in a Multidisciplinary Setting","volume":"9","author":"Yang","year":"2020","journal-title":"Adv. Wound Care"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/iwj.13535","article-title":"Identification of potential circRNAs and circRNA-miRNA-mRNA regulatory network in the development of diabetic foot ulcers by integrated bioinformatics analysis","volume":"18","author":"Tian","year":"2020","journal-title":"Int. Wound J."},{"key":"ref_266","first-page":"8117","article-title":"Serum and exosomal hsa_circ_0000907 and hsa_circ_0057362 as novel biomarkers in the early diagnosis of diabetic foot ulcer","volume":"24","author":"Chen","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/iwj.13420","article-title":"Combined analysis of circRNA and mRNA profiles and interactions in patients with Diabetic Foot and Diabetes Mellitus","volume":"17","author":"Zhao","year":"2020","journal-title":"Int. Wound J."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.5114\/aoms.2019.84699","article-title":"Co-expression network analysis revealing the key lncRNAs in diabetic foot ulcers","volume":"15","author":"Yu","year":"2019","journal-title":"Arch. Med. Sci."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/wrr.12850","article-title":"Decreased expression of miR-24 in peripheral plasma of type 2 diabetes mellitus patients associated with diabetic foot ulcer","volume":"28","author":"Li","year":"2020","journal-title":"Wound Repair. Regen."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/9825028","article-title":"Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers","volume":"2020","author":"Teena","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ijbiomac.2018.08.011","article-title":"Association of hypoxia inducible factor-1 alpha exon 12 mutation in diabetic patients with and without diabetic foot ulcer","volume":"119","author":"Pichu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/j.ijbiomac.2018.07.083","article-title":"Single nucleotide polymorphisms in cytokine\/chemokine genes are associated with severe infection, ulcer grade and amputation in diabetic foot ulcer","volume":"118","author":"Viswanathan","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"155173","DOI":"10.1016\/j.cyto.2020.155173","article-title":"Extensive serum biomarker analysis before and after treatment in healing of diabetic foot ulcers using a cytokine antibody array","volume":"133","author":"Wang","year":"2020","journal-title":"Cytokine"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ncrna.2020.07.001","article-title":"Integrated analysis of circRNA-miRNA-mRNA regulatory network identifies potential diagnostic biomarkers in diabetic foot ulcer","volume":"5","author":"Liao","year":"2020","journal-title":"Non-Coding RNA Res."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"105302","DOI":"10.1016\/j.cmpb.2019.105302","article-title":"Analysis for warning factors of type 2 diabetes mellitus complications with Markov blanket based on a Bayesian network model","volume":"188","author":"Liu","year":"2020","journal-title":"Comput. Methods Programs Biomed."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1016\/S2589-7500(19)30128-1","article-title":"Innovative intelligent insole system reduces diabetic foot ulcer recurrence at plantar sites: A prospective, randomised, proof-of-concept study","volume":"1","author":"Abbott","year":"2019","journal-title":"Lancet Digit. Health"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1177\/1932296816689105","article-title":"Smarter Sole Survival: Will Neuropathic Patients at High Risk for Ulceration Use a Smart Insole-Based Foot Protection System?","volume":"11","author":"Najafi","year":"2017","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_278","doi-asserted-by":"crossref","unstructured":"Fernando, M., Woelfel, S.L., Perry, D., Najafi, B., Khan, T., DuBourdieu, C., Shin, L., and Armstrong, D.G. (2021). Dosing Activity and Returning to Pre-Ulcer Function in Diabetic Foot Remission: Patient Recommendations and Guidance from the Limb Preservation Consortium at USC and The National Rehabilitation Center at Rancho Los Amigos. J. Am. Podiatr. Med Assoc.","DOI":"10.7547\/20-166"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13063-019-3623-x","article-title":"Study protocol for a randomized controlled trial to test for preventive effects of diabetic foot ulceration by telemedicine that includes sensor-equipped insoles combined with photo documentation","volume":"20","author":"Ming","year":"2019","journal-title":"Trials"},{"key":"ref_280","doi-asserted-by":"crossref","unstructured":"Beach, C., Cooper, G., Weightman, A., Hodson-Tole, E., Reeves, N., and Casson, A. (2021). Monitoring of Dynamic Plantar Foot Temperatures in Diabetes with Personalised 3D-Printed Wearables. Sensors, 21.","DOI":"10.3390\/s21051717"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"e12460","DOI":"10.2196\/12460","article-title":"Continuous Temperature-Monitoring Socks for Home Use in Patients With Diabetes: Observational Study","volume":"20","author":"Reyzelman","year":"2018","journal-title":"J. Med Internet Res."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1177\/1932296817709022","article-title":"An Optical-Fiber-Based Smart Textile (Smart Socks) to Manage Biomechanical Risk Factors Associated With Diabetic Foot Amputation","volume":"11","author":"Najafi","year":"2017","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"108074","DOI":"10.1016\/j.diabres.2020.108074","article-title":"Accuracy of a foot temperature monitoring mat for predicting diabetic foot ulcers in patients with recent wounds or partial foot amputation","volume":"161","author":"Gordon","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2337\/dc16-2294","article-title":"Feasibility and Efficacy of a Smart Mat Technology to Predict Development of Diabetic Plantar Ulcers","volume":"40","author":"Frykberg","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/wrr.12628","article-title":"Monitoring of pH and temperature of neuropathic diabetic and nondiabetic foot ulcers for 12 weeks: An observational study","volume":"26","author":"Gethin","year":"2018","journal-title":"Wound Repair. Regen."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1177\/1932296818803115","article-title":"Is Thermal Imaging a Useful Predictor of the Healing Status of Diabetes-Related Foot Ulcers? A Pilot Study","volume":"13","author":"Aliahmad","year":"2018","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2147\/IJN.S121726","article-title":"Temperature- and pH-sensitive wearable materials for monitoring foot ulcers","volume":"12","author":"Salvo","year":"2017","journal-title":"Int. J. Nanomed."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/10\/1072\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:10:32Z","timestamp":1760166632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/10\/1072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,8]]},"references-count":287,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["medicina57101072"],"URL":"https:\/\/doi.org\/10.3390\/medicina57101072","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,8]]}}}