{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:29:24Z","timestamp":1792794564778,"version":"4.5.0"},"reference-count":26,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Gestational diabetes mellitus (GDM) represents one of the most common complications during pregnancy, being associated with numerous maternal and neonatal complications. The study aimed to analyze maternal and neonatal complications associated with GDM. The risk factors of GDM and of the maternal and neonatal complications were studied in order to prevent their occurrence. Materials and Methods: The study included 97 women in the study, who underwent an oral glucose tolerance test (OGTT) between weeks 24\u201328 of pregnancy, consequently being divided into two groups: pregnant women with and without GDM. Statistical analysis was performed using the SPSS 26.0 software and MATLAB fitglm, the results being considered statistically significant if p &lt; 0.05. Results: We observed statistically significant differences between the group of women with and without GDM, regarding gestational hypertension (17.6% vs. 0%), preeclampsia (13.72% vs. 0%), and cesarean delivery (96.1% vs. 78,3%). Data on the newborn and neonatal complications: statistically significant differences were recorded between the two groups (GDM vs. no GDM) regarding the average weight at birth (3339.41 \u00b1 658.12 g vs. 3122.83 \u00b1 173.67 g), presence of large for gestational age (21.6% vs. 0%), macrosomia (13.7% vs. 0%), excessive fetal growth (35.3% vs. 0%), respiratory distress (31.4% vs. 0%), hospitalization for at least 24 h in the Neonatal Intensive Care Unit (9.80% vs. 0%), and APGAR score &lt;7 both 1 and 5 min following birth (7.8% vs. 0%). Additionally, the frequency of neonatal hypoglycemia and hyperbilirubinemia was higher among newborns from mothers with GDM. Conclusions: The screening and diagnosis of GDM is vital, and appropriate management is required for the prevention of maternal and neonatal complications associated with GDM. It is also important to know the risk factors for GDM and attempt to prevent their appearance.<\/jats:p>","DOI":"10.3390\/medicina57111170","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T23:51:36Z","timestamp":1635465096000},"page":"1170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Analysis of Maternal and Neonatal Complications in a Group of Patients with Gestational Diabetes Mellitus"],"prefix":"10.3390","volume":"57","author":[{"given":"Agnesa","family":"Preda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Ginecology, Clinical County Emergency Hospital, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-5689","authenticated-orcid":false,"given":"Vlad","family":"P\u0103dureanu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mo\u021ba","sequence":"additional","affiliation":[{"name":"Department of Diabetes Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela-Gabriela","family":"\u0218tefan","sequence":"additional","affiliation":[{"name":"Department of Diabetes Nutrition and Metabolic Diseases, Calafat Municipal Hospital, 205200 Calafat, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru Cristian","family":"Com\u0103nescu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Ginecology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucre\u021biu","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia Roxana","family":"Mazilu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Ginecology, Clinical County Emergency Hospital, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionela Mihaela","family":"Vladu","sequence":"additional","affiliation":[{"name":"Department of Diabetes Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2021). 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes\u20142021. Diabetes Care, 44, S15\u2013S33.","DOI":"10.2337\/dc21-S002"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ornoy, A., Becker, M., Weinstein-Fudim, L., and Ergaz, Z. (2021). Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062965"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s13410-020-00802-x","article-title":"Association of gestational diabetes mellitus with adverse pregnancy outcomes: Our experience and meta-analysis","volume":"40","author":"Shen","year":"2020","journal-title":"Int. J. Diabetes Dev. Ctries."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Hedderson, M.M., Feng, J., Mevi, A.A., and Ferrara, A. (2017). The Pregnancy Environment and Lifestyle Study (PETALS): A pop-ulation-based longitudinal multi-racial birth cohort. BMC Pregnancy Childbirth., 17.","DOI":"10.1186\/s12884-017-1301-0"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.diabres.2013.08.003","article-title":"International Diabetes Federation","volume":"101","author":"Nolan","year":"2013","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s40618-017-0791-y","article-title":"Impact of risk factors for gestational diabetes (GDM) on pregnancy outcomes in women with GDM","volume":"41","author":"Filardi","year":"2018","journal-title":"J. Endocrinol. Investig."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bpobgyn.2014.04.025","article-title":"Gestational diabetes as one of the \u201cgreat obstetrical syndromes\u201d\u2014The maternal, placental, and fetal dialog","volume":"29","author":"Baschat","year":"2015","journal-title":"Best Pr. Res. Clin. Obs. Gynaecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102.e1","DOI":"10.1016\/j.ajog.2018.10.027","article-title":"Gestational diabetes mellitus is associated with adverse outcomes in twin pregnan-cies","volume":"220","author":"Hiersch","year":"2019","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"(2014). Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy: A World Health Or-ganization Guideline. Diabetes Res. Clin. Pract., 103, 341\u2013363.","DOI":"10.1016\/j.diabres.2013.10.012"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Panaitescu, A., Ciobanu, A., Popa, M., Duta, I., Gica, N., Peltecu, G., and Veduta, A. (2021). Screening for Gestational Diabetes during the COVID-19 Pandemic\u2014Current Recommendations and Their Consequences. Medicina, 57.","DOI":"10.3390\/medicina57040381"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2337\/dc12-1428","article-title":"Diagnostic and Prognostic Performances Over 9 Years of a Selective Screening Strategy for Gestational Diabetes Mellitus in a Cohort of 18,775 Subjects","volume":"36","author":"Cosson","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.18410\/jebmh\/2014\/301","article-title":"Immunological causes of bad obstetric history","volume":"1","author":"Koppad","year":"2014","journal-title":"J. Evid. Med. Healthcare."},{"key":"ref_13","unstructured":"World Health Organization (2008). Waist Circumference and Waist\u2014Hip Ratio: Report of a WHO Expert Consultation, Geneva, 8\u201311 December 2008, World Health Organization."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"International Association of Diabetes and Pregnancy Study Groups Consensus Panel (2010). International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care., 33, 676\u2013682.","DOI":"10.2337\/dc09-1848"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.siny.2016.08.007","article-title":"Neonatal hypoglycemia","volume":"22","author":"Adamkin","year":"2017","journal-title":"Semin Fetal Neonatal Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1038\/sj.jp.7210640","article-title":"Jaundice Technologies: Prediction of Hyperbilirubinemia in Term and Near-Term Newborns","volume":"21","author":"Bhutani","year":"2001","journal-title":"J. Perinatol."},{"key":"ref_17","unstructured":"(2021, September 20). Available online: https:\/\/www.who.int\/news\/item\/16-06-2021-caesarean-section-rates-continue-to-rise-amid-growing-inequalities-in-access-who."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1624\/105812405X72276","article-title":"Increasing Cesarean Birth Rates: A Clash of Cultures?","volume":"14","author":"Moore","year":"2005","journal-title":"J. P\u00e9rinat. Educ."},{"key":"ref_19","first-page":"935","article-title":"Prevalence and risk factors of cesarean section in a population of Tunisian diabetic pregnant women","volume":"85","author":"Denguezli","year":"2007","journal-title":"Tunis Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1113\/JP274937","article-title":"The peripheral chemoreflex: Indefatigable guardian of fetal physio-logical adaptation to labour","volume":"596","author":"Lear","year":"2018","journal-title":"J. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Xodo, S., Londero, A.P., D\u2019Agostin, M., Novak, A., Galasso, S., Pittini, C., Baccarini, G., Grimaldi, F., and Driul, L. (2021). Is Glycated Hemoglobin A1c Level Associated with Adverse Pregnancy Outcomes of Women Affected by Pre-Gestational Diabetes?. Medicina, 57.","DOI":"10.3390\/medicina57050461"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1038\/s41598-018-22546-9","article-title":"Causes and risk factors for singleton stillbirth in Japan: Analysis of a nationwide perinatal database, 2013\u20132014","volume":"8","author":"Haruyama","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tjog.2014.04.003","article-title":"Major risk factors for stillbirth in different trimesters of pregnancy\u2014A systematic review","volume":"53","author":"Liu","year":"2014","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zile, I., Ebela, E., and Rozenfelde, I.R. (2019). Maternal Risk Factors for Stillbirth: A Registry\u2013Based Study. Medicina, 55.","DOI":"10.3390\/medicina55070326"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1007\/s13300-020-00932-9","article-title":"Pre-Gestational Diabetes and Pregnancy Outcomes","volume":"11","author":"Ali","year":"2020","journal-title":"Diabetes Ther."},{"key":"ref_26","first-page":"E865","article-title":"Effect of low-level basal plus marked \u201cpulsatile\u201d hyper-glycemia on insulin secretion in fetal sheep","volume":"271","author":"Carver","year":"1996","journal-title":"Am. J. Physiol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/11\/1170\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:21:46Z","timestamp":1760167306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/57\/11\/1170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,28]]},"references-count":26,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["medicina57111170"],"URL":"https:\/\/doi.org\/10.3390\/medicina57111170","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,28]]}}}