{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:14:53Z","timestamp":1767849293588,"version":"3.49.0"},"reference-count":31,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Our study aimed to investigate the gross anatomy aspects of the fossa ovalis (FO) and the presence of some anatomical variation resulting from the incomplete fusion of septum primum and septum secundum, such as an atrial septal pouch (SP) and left atrial septal ridge. Materials and Methods: Thirty-one adult human hearts removed from formalin-fixed specimens were examined to provide information about the morphology of the FO. The organs were free of any gross anatomically visible pathological conditions. Results: The most common variants were the FO located in the inferior part of the interatrial septum (64.51%), circular (61.3%), with a net-like structure (51.62%), prominent limbus (93.55%), and patent foramen ovale (PFO) (25.8%). The right SP was observed in 9.67% of specimens, the left SP was observed in 29.03% of cases, and in 51.61% of cases, a double SP was observed. One sample presented a right SP and a double left SP, and one case showed a triple left SP, which was not reported previously to our knowledge. Conclusions: Knowledge of the interatrial septal anatomy becomes important for interventional cardiologists and should be documented before transeptal puncture.<\/jats:p>","DOI":"10.3390\/medicina57111254","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T02:42:28Z","timestamp":1637116948000},"page":"1254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Morphological Study of Fossa Ovalis in Formalin-Fixed Human Hearts and Its Clinical Importance"],"prefix":"10.3390","volume":"57","author":[{"given":"Monica Adriana","family":"Vaida","sequence":"first","affiliation":[{"name":"Department of Anatomy and Embryology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caius Glad","family":"Streian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0111-6606","authenticated-orcid":false,"given":"Cristina","family":"Gug","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawwaf Sebastian","family":"Damen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelina Maria","family":"Jianu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Grigori\u021b\u0103","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Grigori\u021b\u0103","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1161\/CIRCEP.113.000956","article-title":"Editor\u2019s perspective: The interatrial septum","volume":"6","author":"Asirvatham","year":"2013","journal-title":"Circ. 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