{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:44:06Z","timestamp":1793943846050,"version":"4.8.0"},"reference-count":24,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Fetomaternal hemorrhage is defined as transfer of fetal blood into placental circulation and therefore into maternal circulation during pregnancy, and represents an important contributor to intrauterine fetal demise and neonatal death. The condition is rarely diagnosed prenatally because clinical findings are often nonspecific, and it is unpredictable. In this paper we present an illustrative case of massive spontaneous fetomaternal hemorrhage where the diagnosis was highly suspected antenatally based on maternal reported reduced fetal movements, abnormal suggestive cardiotocographic trace, and increased peak systolic velocity in the fetal middle cerebral artery. We discuss obstetrical and neonatal management and review the current knowledge in the literature. Maintaining a high index of suspicion for this condition allows the obstetrician to plan for adequate diagnostic tests, arrange intrauterine treatment or delivery, and prepare the neonatal team.<\/jats:p>","DOI":"10.3390\/medicina57121285","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T05:42:10Z","timestamp":1638250930000},"page":"1285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Severe Neonatal Anemia Due to Spontaneous Massive Fetomaternal Hemorrhage at Term: An Illustrative Case with Suspected Antenatal Diagnosis and Brief Review of Current Knowledge"],"prefix":"10.3390","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8425-6307","authenticated-orcid":false,"given":"Nicolae","family":"Gic\u0103","sequence":"first","affiliation":[{"name":"Carol Davila Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 011171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9400-8991","authenticated-orcid":false,"given":"Radu","family":"Botezatu","sequence":"additional","affiliation":[{"name":"Carol Davila Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 011171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Demetrian","sequence":"additional","affiliation":[{"name":"Filantropia Clinical Hospital, 011171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Vayna","sequence":"additional","affiliation":[{"name":"Filantropia Clinical Hospital, 011171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9745-9891","authenticated-orcid":false,"given":"Br\u00eendu\u0219a Ana","family":"Cimpoca-Raptis","sequence":"additional","affiliation":[{"name":"Carol Davila Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 011171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Marina","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Carol Davila Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 011171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Gica","sequence":"additional","affiliation":[{"name":"Carol Davila Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 011171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheorghe","family":"Peltecu","sequence":"additional","affiliation":[{"name":"Carol Davila Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 011171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Maria","family":"Panaitescu","sequence":"additional","affiliation":[{"name":"Carol Davila Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 011171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1046\/j.1537-2995.1990.30490273444.x","article-title":"Fetomaternal hemorrhage: Incidence, risk factors, time of occurrence, and clinical effects","volume":"30","author":"Sebring","year":"1990","journal-title":"Transfusion"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/jmf.13.2.128.132","article-title":"Large fetomaternal hemorrhage: Clinical presentation and outcome","volume":"13","author":"Kecskes","year":"2003","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1097\/AOG.0b013e3181da7929","article-title":"Fetomaternal hemorrhage","volume":"115","author":"Wylie","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/GCO.0000000000000248","article-title":"Fetomaternal hemorrhage complicated pregnancy: Risks, identification, and management","volume":"28","author":"Stefanovic","year":"2016","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/uog.17336","article-title":"Sonographic visualization of in-vivo formation of intervillous (Kline\u2019s) hemorrhage","volume":"50","author":"Paladini","year":"2017","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/1093526616687652","article-title":"Placental Pathologic Features in Fetomaternal Hemorrhage Detected by Flow Cy-tometry","volume":"20","author":"Lewis","year":"2017","journal-title":"Pediatr. Dev. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2350\/13-12-1419-OA.1","article-title":"Pathological Findings in Feto-Maternal Hemorrhage","volume":"17","author":"Carles","year":"2014","journal-title":"Pediatr. Dev. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00404-015-3686-1","article-title":"Fetomaternal hemorrhage (FMH), an update: Review of literature and an illustrative case","volume":"292","author":"Maier","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/01443615.2016.1225022","article-title":"Keep in mind foetomaternal haemorrage in case of reduced foetal movements: A successful obstetric management","volume":"37","author":"Cozzolino","year":"2016","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s13256-019-2170-0","article-title":"Sawtooth fetal heart rate pattern associated with a favorable neurological out-come in an infant: A case report","volume":"13","author":"Ohira","year":"2019","journal-title":"J. Med. Case Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.pbj.2017.01.004","article-title":"Recognition of chronic hypoxia and pre-existing foetal injury on the cardiotocograph (CTG): Urgent need to think beyond the guidelines","volume":"2","author":"Pereira","year":"2017","journal-title":"Porto Biomed. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1056\/NEJM200007063430114","article-title":"Noninvasive diagnosis of fetal anemia by Doppler ultrasonography","volume":"343","author":"Mari","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000092461","article-title":"Doppler Sonography of the Fetal Middle Cerebral Artery in the Management of Massive Fetomaternal Hemorrhage","volume":"21","author":"Eichbaum","year":"2006","journal-title":"Fetal Diagn. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"540.e1","DOI":"10.1016\/j.ajog.2021.04.257","article-title":"Fetomaternal hemorrhage: Evaluation of recurrence within a large integrated healthcare system","volume":"225","author":"Boller","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_15","first-page":"621","article-title":"Clinical application of the Kleihauer-Betke test","volume":"38","author":"Dupre","year":"1993","journal-title":"J. Reprod. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0002-9378(84)80070-8","article-title":"Detection of fetal erythrocytes in maternal blood post partum with the fluorescence-activated cell sorter","volume":"148","author":"Medearis","year":"1984","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1136\/bmj.3.5817.31","article-title":"Clinical Problems: Quantitation of Transplacental Haemorrhage","volume":"3","author":"Mollison","year":"1972","journal-title":"BMJ"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000357797","article-title":"Impact of Physician Awareness on Diagnosis of Fetomaternal Hemorrhage","volume":"105","author":"Stroustrup","year":"2014","journal-title":"Neonatology"},{"key":"ref_19","first-page":"649","article-title":"Fetomaternal bleeding as a cause for \u201cunexplained\u201d fetal death","volume":"60","author":"Laube","year":"1982","journal-title":"Obstet. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/aogs.12762","article-title":"The contribution of massive fetomaternal hemorrhage to antepartum stillbirth: A 25-year cross-sectional study","volume":"94","author":"Walsh","year":"2015","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/uog.190","article-title":"Doppler sonography for predicting fetal anemia caused by massive fetomaternal hemorrhage","volume":"22","author":"Sueters","year":"2003","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1159\/000093881","article-title":"Dufour, P., Subtil D.; Deruelle, F. Successful in utero treatment of chronic and mas-sive fetomaternal hemorrhage with fetal hydrops","volume":"21","author":"Rubod","year":"2006","journal-title":"Fetal Diagn. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000362812","article-title":"Intrauterine Blood Transfusion: Current Indications and Associated Risks","volume":"36","author":"Lindenburg","year":"2014","journal-title":"Fetal Diagn. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Popescu, M.R., Panaitescu, A.M., Pavel, B., Zagrean, L., Peltecu, G., and Zagrean, A.-M. (2020). Getting an Early Start in Understanding Perinatal Asphyxia Impact on the Cardiovascular System. Front. 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