{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:05:21Z","timestamp":1792749921318,"version":"4.5.0"},"reference-count":45,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Hypertension is a global health problem and a major risk factor for cardiovascular diseases. Vitamin D deficiency is closely related to high blood pressure and the development of hypertension. This study investigated the relationship between the vitamin D and blood pressure status in healthy adults, and their 8-year follow-up was added. Materials and Methods: A total of 491 healthy middle-aged participants without any chronic illness, ages 21 to 67 at baseline, were divided into two groups as non-optimal blood pressure (NOBP) and optimal blood pressure (OBP). NOBP group was divided into two subgroups: normal (NBP) and high normal blood pressure (HNBP). Serum 25-hydroxy vitamin D levels were measured with the immunoassay method. 8-year follow-up of the participants was added. Results: The average vitamin D level was detected 32.53 \u00b1 31.50 nmol\/L in the OBP group and 24.41 \u00b1 14.40 nmol\/L in the NOBP group, and a statistically significant difference was found (p &lt; 0.001). In the subgroup analysis, the mean vitamin D level was detected as 24.69 \u00b1 13.74 and 24.28 \u00b1 14.74 nmol\/L in NBP and HNBP, respectively. Together with parathyroid hormone, other metabolic parameters were found to be significantly higher in the NOBP. During a median follow-up of 8 years, higher hypertension development rates were seen in NOBP group (p &lt; 0.001). Conclusions: The low levels of vitamin D were significantly associated with NBP and HNBP. The low levels of vitamin D were also associated with the development of hypertension in an 8-year follow-up.<\/jats:p>","DOI":"10.3390\/medicina57121297","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T05:42:10Z","timestamp":1638250930000},"page":"1297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Vitamin D Deficiency Is a Potential Risk for Blood Pressure Elevation and the Development of Hypertension"],"prefix":"10.3390","volume":"57","author":[{"given":"Yusuf","family":"Karadeniz","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Necmettin Erbakan University, Konya 42010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5839-9104","authenticated-orcid":false,"given":"Fatma","family":"\u00d6zpamuk-Karadeniz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Private B\u00fcy\u00fck\u015fehir Hospital, Konya 42060, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9239-9132","authenticated-orcid":false,"given":"S\u00fcleyman","family":"Ahbab","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences, Haseki Training and Research Hospital, Istanbul 34270, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-2575","authenticated-orcid":false,"given":"Esra","family":"Atao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences, Haseki Training and Research Hospital, Istanbul 34270, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnay","family":"Can","sequence":"additional","affiliation":[{"name":"Departments of Public Health, Cerrahpa\u015fa Medical Faculty, Istanbul University, Istanbul 34098, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00198-009-0954-6","article-title":"IOF Committee of Scientific Advisors (CSA) Nutrition Working Group. 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