{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:36:45Z","timestamp":1787233005160,"version":"build-2736575974"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Insulin resistance (IR) is frequently associated with chronic low-grade inflammation and has an important role as a mediator in the development of liver disease. Thus, this study aimed to explore the relationship between two indexes of IR and abnormal liver function parameters. Materials and Methods: This cross-sectional study obtained data of 41,510 men and 92,357 women aged \u226530 years from a private health screening institute in Taiwan. Two IR indexes namely triglyceride-glucose (TyG) index and triglycerides to high-density lipoprotein cholesterol (TG\/HDL-C) ratio were used to examine their relationship to predict abnormal liver function parameters (aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP)). Results: Positive trend was shown for the association of TyG index in the highest quintile (Q5) and risk of high AST (OR = 1.45, 95% CI: 1.33\u20131.57), high ALT (OR = 1.85, 95% CI: 1.73\u20131.97), high GGT (OR = 2.04, 95% CI: 1.93\u20132.15), and high ALP (OR = 1.13, 95% CI: 1.07\u20131.19) compared with the median quintile (Q3) in the fully adjusted model. Similarly, participants in the Q5 of the TG\/HDL-C ratio were associated with 1.38 (95% CI: 1.27\u20131.49), 1.71 (95% CI: 1.61\u20131.82), 1.75 (95% CI: 1.66\u20131.84), and 1.21 (1.16\u20131.27) odds for having high AST, ALT, GGT, and ALP respectively. The AUC (95% CI) value of the TyG index for predicting high AST, high ALT, and high GGT was 0.699 (0.692\u20130.705), 0.738 (0.734\u20130.742), and 0.752 (0.749\u20130.755), respectively. Meanwhile, the AUC (95% CI) of the TG\/HDL-C ratio for predicting high AST, high ALT, and high GGT was 0.680 (0.673\u20130.686), 0.738 (0.734\u20130.742), 0.734 (0.731\u20130.738), respectively. Conclusions: Our study supported that the TyG index and TG\/HDL-C ratio may be useful as non-invasive methods to predict the existence of impaired liver function in the early stage.<\/jats:p>","DOI":"10.3390\/medicina58010004","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T09:50:43Z","timestamp":1640080243000},"page":"4","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of Two Indices of Insulin Resistance Marker with Abnormal Liver Function Tests: A Cross-Sectional Population Study in Taiwanese Adults"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-1953","authenticated-orcid":false,"given":"Adi-Lukas","family":"Kurniawan","sequence":"first","affiliation":[{"name":"Research Center for Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences, 365 Ming-te Road, Beitou District, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yeh","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Information Management, National Taipei University of Nursing and Health Sciences, 365 Ming-te Road, Beitou District, Taipei 112, Taiwan"},{"name":"Master Program in Global Health and Development, College of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Xinyi District, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3610-9580","authenticated-orcid":false,"given":"Jane C.-J.","family":"Chao","sequence":"additional","affiliation":[{"name":"Master Program in Global Health and Development, College of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"Nutrition Research Center, Taipei Medical University Hospital, 252 Wu-Hsing Street, Xinyi District, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-7137","authenticated-orcid":false,"given":"Rathi","family":"Paramastri","sequence":"additional","affiliation":[{"name":"School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Xinyi District, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1178-1626","authenticated-orcid":false,"given":"Hsiu-An","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Information Engineering, Tamkang University, 151 Yingzhuan Road, Tamsui District, New Taipei 251, Taiwan"},{"name":"National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-1094","authenticated-orcid":false,"given":"Amadou-Wurry","family":"Jallow","sequence":"additional","affiliation":[{"name":"Department of Health Technology, National Taipei University of Nursing and Health Sciences, 365 Ming-te Road, Beitou District, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/jgh.13264","article-title":"Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. 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