{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:28:07Z","timestamp":1760909287895,"version":"build-2065373602"},"reference-count":9,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>We describe here the case of a female patient with type I diabetes who developed active Charcot neuroarthropathy in the foot. Due to therapeutic noncompliance, talus necrosis was discovered 2 years after the presentation of neuroarthropathy. The impact of untreated neuroarthropathy on the bone is commonly described as fracture and joint dislocation, but we describe the complete disappearance of the bony structure and its necrosis associated with active neuroarthropathy in a patient who refused offloading.<\/jats:p>","DOI":"10.3390\/medicina58010011","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T02:01:19Z","timestamp":1640224879000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fracture of the Bone Inducing Its Necrosis as the End Point in the Evolution of Untreated Neuroarthropathy"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-4300","authenticated-orcid":false,"given":"Dured","family":"Dardari","sequence":"first","affiliation":[{"name":"Diabetology Department, Centre Hopitalier Sud Francilien, 91100 Corbeil-Essonnes, France"},{"name":"LBEPS, IRBA, Universit\u00e9 Paris Saclay, 91025 Evry, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Penfornis","sequence":"additional","affiliation":[{"name":"Diabetology Department, Centre Hopitalier Sud Francilien, 91100 Corbeil-Essonnes, France"},{"name":"Paris-Sud Medical School, Paris-Saclay University, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1590\/1806-9282.66.2.216","article-title":"Stiffness degree of ankle range of motion in diabetic patients with atypical amputation","volume":"66","year":"2020","journal-title":"Rev. Assoc. Med. Bras."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s11892-005-0050-z","article-title":"Theories concerning the pathogenesis of the acute Charcot foot suggest future therapy","volume":"5","author":"Jeffcoate","year":"2005","journal-title":"Curr. Diabetes Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.2337\/dc11-0844","article-title":"The Charcot foot in diabetes","volume":"34","author":"Rogers","year":"2011","journal-title":"Diabetes Care"},{"key":"ref_4","first-page":"w13948","article-title":"Is the Eichenholtz classification still valid for the diabetic Charcot foot?","volume":"144","author":"Chantelau","year":"2014","journal-title":"Swiss Med. Wkly."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1046\/j.1464-5491.2001.00566.x","article-title":"Avascular necrosis not Charcot\u2019s","volume":"18","author":"Samarasinghe","year":"2001","journal-title":"Diabet. Med."},{"key":"ref_6","first-page":"84","article-title":"On an odd double-sided change of the tarsal navicular","volume":"201","year":"1927","journal-title":"Dtsch. Z. Chir."},{"key":"ref_7","first-page":"191","article-title":"Infraction of the second metatarsal bone","volume":"19","author":"Freiberg","year":"1914","journal-title":"Surg. Gynecol. Obstet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4049\/jimmunol.178.1.192","article-title":"Osteoprotegerin reduces the serum level of receptor activator of NF-\u03baB ligand derived from osteoblasts","volume":"178","author":"Nakamichi","year":"2007","journal-title":"J. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1177\/107110070602701007","article-title":"Cytokine-induced osteoclastic bone resorption in charcot arthropathy: An immunohistochemical study","volume":"27","author":"Baumhauer","year":"2006","journal-title":"Foot Ankle Int."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/1\/11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:51:05Z","timestamp":1760169065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["medicina58010011"],"URL":"https:\/\/doi.org\/10.3390\/medicina58010011","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2021,12,22]]}}}