{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:42:09Z","timestamp":1767994929533,"version":"3.49.0"},"reference-count":37,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"publisher","award":["KNW-1-124\/N\/8\/0"],"award-info":[{"award-number":["KNW-1-124\/N\/8\/0"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Hypertrophic cardiomyopathy (HCM) depends on the primary impairment of sarcomeres, but it can also be associated with secondary alterations in the heart related to oxidative stress. The present study aimed to examine oxidative-antioxidant disturbances in patients with HCM compared with control individuals. Materials and Methods: We enrolled 52 consecutive HCM patients and 97 controls without HCM. The groups were matched for age, body mass index, and sex. Peripheral blood was collected from all patients to determine the total antioxidant capacity (TAC), total oxidant status (TOS), lipid hydroperoxide (LPH), and malondialdehyde (MDA). The oxidative stress index (OSI) was defined as the ratio of the TOS level to the TAC level. Results: The median age was 52 years, and 58.4% were female. The area under the curve (AUC) indicated good predictive power for the TAC and TOS [AUC 0.77 (0.69\u20130.84) and 0.83 (0.76\u20130.90), respectively], as well as excellent predictive power for the OSI [AUC 0.87 (0.81\u20130.93)] for HCM detection. Lipid peroxidation markers also demonstrated good predictive power to detect HCM patients [AUCLPH = 0.73, AUCMDA = 0.79]. Conclusions: The TOS, the TAC, LPH levels, and MDA levels have good predictive power for HCM detection. The holistic assessment of oxidative stress by the OSI had excellent power and could identify patients with HCM.<\/jats:p>","DOI":"10.3390\/medicina58010031","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T01:06:54Z","timestamp":1640567214000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Oxidative Stress Markers in Hypertrophic Cardiomyopathy"],"prefix":"10.3390","volume":"58","author":[{"given":"Bo\u017cena","family":"Szygu\u0142a-Jurkiewicz","sequence":"first","affiliation":[{"name":"3rd Department of Cardiology, School of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-422X","authenticated-orcid":false,"given":"Wioletta","family":"Szczurek-Wasilewicz","sequence":"additional","affiliation":[{"name":"Silesian Center for Heart Diseases, 3rd Department of Cardiology, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Osadnik","sequence":"additional","affiliation":[{"name":"Silesian Center for Heart Diseases, 3rd Department of Cardiology, 41-800 Zabrze, Poland"},{"name":"Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Frycz-Kurek","sequence":"additional","affiliation":[{"name":"Silesian Center for Heart Diseases, 3rd Department of Cardiology, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Macio\u0142-Skurk","sequence":"additional","affiliation":[{"name":"Silesian Center for Heart Diseases, 3rd Department of Cardiology, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Ma\u0142yszek-Tumidajewicz","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Vascular and Endovascular Surgery and Transplantology in Zabrze, Silesian Center for Heart Diseases, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-7407","authenticated-orcid":false,"given":"Micha\u0142","family":"Skrzypek","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Romuk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"G\u0105sior","sequence":"additional","affiliation":[{"name":"3rd Department of Cardiology, School of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Banach","sequence":"additional","affiliation":[{"name":"Polish Mothers Memorial Hospital Research Institute, 90-419 \u0141\u00f3d\u017a, Poland"},{"name":"Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, 90-419 \u0141\u00f3d\u017a, Poland"},{"name":"Cardiovascular Research Centre, University of Zielona Gora, 65-046 Zielona Gora, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek J.","family":"J\u00f3\u017awiak","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health, Faculty of Medicine, University of Opole, 45-040 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jacc.2012.02.068","article-title":"Genetics of hypertrophic cardiomyopathy after 20 years: Clinical perspectives","volume":"60","author":"Maron","year":"2012","journal-title":"J. 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