{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:29:45Z","timestamp":1767598185460,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T00:00:00Z","timestamp":1640476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Phyllodes Tumor (PT) is a rare fibroepithelial breast tumor that can behave differently depending on its biologic features. Traditionally, PTs are classified by their histologic features into benign, borderline, and malignant. In most cases that were reported, all PTs may recur, but only the borderline and malignant PT can metastasize. PT usually occurs as a breast lump or accidental finding on ultrasound (US) examination. The clinical features include a well-defined breast mass, regular or lobulated. The diagnosis is based on the integration of morphology features, but remains challenging, particularly in the distinction from fibroadenomas. We report a case of a 36-year-old patient who presented for a voluminous breast mass, rapidly growing in the past 3\u20134 months. At presentation, the patient was 19 weeks pregnant. The breast tumor had the clinical and US aspect of PT. A core needle biopsy was obtained, confirming a benign PT, and local excision was performed with no postoperative complications. The final pathology report showed a borderline PT with close resection margins of 1 mm. Immunohistochemistry (IHC) established the diagnosis of malignant PT with heterologous sarcomatous differentiation. The case was discussed in the multidisciplinary tumor board (MDT) and mastectomy was recommended. The patient fully consented but refused surgery at 25 weeks\u2019 gestation, fearing premature delivery. The right breast was closely monitored by US, and at 9 weeks after the first surgery, signs of local recurrence were detected. At 35 weeks\u2019 gestation, right mastectomy was performed, with no perioperative complications. The pregnancy was closely followed up and no complication were found. The final pathology report describes multiples PT recurrences with heterologous sarcomatous differentiation. The pregnancy outcome was uneventful, and the patient delivered a healthy child vaginally at term with no peripartum complication. Postpartum, a computer tomography (CT) examination of the head, thorax, abdomen and pelvis was performed, with no evidence of metastases. Adjuvant chemotherapy and radiotherapy completed the treatment. The follow-up and CT scan showed no metastases or further recurrence 4 years after diagnosis. In conclusion, diagnosis of PT can be difficult, especially because of the easy confusion with fibroadenoma of the breast. There are rare cases when a pathology exam needs further assessment and IHC is recommended for accurate diagnosis. Although malignant PT is rare and accounts for &lt;1% of all breast cancers, the diagnosis and treatment that are recommended are based on the reported cases. Moreover, when complete surgical excision is achieved, the rates of recurrence and distant metastases are low, and adjuvant therapy might not be necessary.<\/jats:p>","DOI":"10.3390\/medicina58010036","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T01:06:54Z","timestamp":1640567214000},"page":"36","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Malignant Phyllodes Tumor of the Breast and Pregnancy: A Rare Case Report and Literature Review"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-992X","authenticated-orcid":false,"given":"Laura","family":"Musta\u021b\u0103","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department, Carol Davila University of Medicine and Pharmacy, 11171 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8425-6307","authenticated-orcid":false,"given":"Nicolae","family":"Gic\u0103","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Carol Davila University of Medicine and Pharmacy, 11171 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9400-8991","authenticated-orcid":false,"given":"Radu","family":"Botezatu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Carol Davila University of Medicine and Pharmacy, 11171 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8228-0584","authenticated-orcid":false,"given":"Raluca","family":"Chirculescu","sequence":"additional","affiliation":[{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Gic\u0103","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Carol Davila University of Medicine and Pharmacy, 11171 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gheorghe","family":"Peltecu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Carol Davila University of Medicine and Pharmacy, 11171 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-6735","authenticated-orcid":false,"given":"Anca Maria","family":"Panaitescu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Carol Davila University of Medicine and Pharmacy, 11171 Bucharest, Romania"},{"name":"Filantropia Clinical Hospital, 11171 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/1097-0142(20001001)89:7<1502::AID-CNCR13>3.0.CO;2-P","article-title":"Primary treatment of cystosarcoma phyllodes of the breast","volume":"89","author":"Chaney","year":"2000","journal-title":"Cancer"},{"unstructured":"Harris, J., Lippman, M.E., Morrow, M., and Osborne, K.C. 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